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Article

Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy

  • Authors:
    • Johnny Kao
    • K.H. Vincent Lau
    • Charles C.L. Tong
    • Chien-Ting Chen
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY, USA, Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA
  • Pages: 835-840
    |
    Published online on: February 23, 2012
       https://doi.org/10.3892/etm.2012.494
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Abstract

Radiation with or without chemotherapy is considered the mainstay of treatment for the majority of patients with oropharyngeal cancer. The goal of this study was to analyze competing causes of mortality in patients with oropharyngeal cancer with long-term follow-up. We queried the Surveillance, Epidemiology and End Results (SEER) database and identified 3728 patients with oropharyngeal cancer treated between 1988 and 2001 with definitive radiotherapy. We analyzed predictors of overall survival and risks of mortality from index oropharyngeal cancer, second primary cancer, cardiovascular disease and other causes using a cumulative incidence analysis and Cox multivariate analysis. With a median follow-up of 6.8 years, the 5- and 10‑year overall survival was 37 and 22%, respectively. At 5 years, the risk of mortality from primary oropharyngeal cancer was 35%. Between years 3 and 10, 69% of mortalities were attributed to causes other than the index cancer. Despite advances in the non-surgical treatment of oropharyngeal cancer, patients remain at significant risk of cancer- and non-cancer-related mortality.
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Copy and paste a formatted citation
Spandidos Publications style
Kao J, Lau KV, Tong CC and Chen C: Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy. Exp Ther Med 3: 835-840, 2012.
APA
Kao, J., Lau, K.V., Tong, C.C., & Chen, C. (2012). Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy. Experimental and Therapeutic Medicine, 3, 835-840. https://doi.org/10.3892/etm.2012.494
MLA
Kao, J., Lau, K. V., Tong, C. C., Chen, C."Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy". Experimental and Therapeutic Medicine 3.5 (2012): 835-840.
Chicago
Kao, J., Lau, K. V., Tong, C. C., Chen, C."Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy". Experimental and Therapeutic Medicine 3, no. 5 (2012): 835-840. https://doi.org/10.3892/etm.2012.494
Copy and paste a formatted citation
x
Spandidos Publications style
Kao J, Lau KV, Tong CC and Chen C: Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy. Exp Ther Med 3: 835-840, 2012.
APA
Kao, J., Lau, K.V., Tong, C.C., & Chen, C. (2012). Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy. Experimental and Therapeutic Medicine, 3, 835-840. https://doi.org/10.3892/etm.2012.494
MLA
Kao, J., Lau, K. V., Tong, C. C., Chen, C."Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy". Experimental and Therapeutic Medicine 3.5 (2012): 835-840.
Chicago
Kao, J., Lau, K. V., Tong, C. C., Chen, C."Competing causes of death in patients with oropharyngeal cancer treated with radiotherapy". Experimental and Therapeutic Medicine 3, no. 5 (2012): 835-840. https://doi.org/10.3892/etm.2012.494
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