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Article

Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients

  • Authors:
    • Masashi Kobayashi
    • Cheng-Long Huang
    • Makoto Sonobe
    • Ryutaro Kikuchi
    • Masashi Ishikawa
    • Jiro Kitamura
    • Ryo Miyahara
    • Toshi Menju
    • Shotaro Iwakiri
    • Kazumi Itoi
    • Ryoji Yasumizu
    • Hiroshi Date
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan, Department of Thoracic Surgery, Hyogo Prefectural Amagasaki Hospital, Amagasaki, Japan, Department of Pathology, Hyogo Prefectural Tsukaguchi Hospital, Amagasaki, Japan
  • Pages: 952-958
    |
    Published online on: March 12, 2012
       https://doi.org/10.3892/etm.2012.511
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Abstract

Malignant pleural mesothelioma (MPM) is an aggressive thoracic tumor with a poor prognosis. We performed a comprehensive clinical study on the intratumoral expression of Wnt1, Wnt2B and Wnt5A in MPM. One hundred and seven MPM patients were investigated. Immunohistochemistry was performed to evaluate the intratumoral expression of Wnt1, Wnt2B, Wnt5A, survivin and c-Myc, and the Ki-67 proliferation index. The apoptotic index was evaluated by the TUNEL method. Among the 107 MPMs, 23 MPMs (21.5%) were Wnt1-high tumors, 72 MPMs (67.3%) were Wnt2B-high tumors and 54 MPMs (50.5%) were Wnt5A-high tumors. There was no correlation among the levels of Wnt expression. The percentage of Wnt2B-positive tumors was significantly higher compared to that of the other Wnts (p<0.0001). Furthermore, intratumoral Wnt2B expression significantly correlated with the expression of survivin (p<0.001) and c-Myc (p<0.001). Regarding tumor biology, the Ki-67 proliferation index was significantly higher in the Wnt2B-high tumors than in the Wnt2B-low tumors (p=0.0438). In addition, the overall survival was significantly lower in patients with Wnt2B-high tumors than in those with Wnt2B-low tumors (p=0.0238). A Cox multivariate analysis also demonstrated the Wnt2B status to be a significant prognostic factor in MPM patients (p=0.0042). Intratumoral Wnt2B expression was associated with the expression of survivin and c-Myc, tumor proliferation and patient survival in MPM. Wnt2B is a potential molecular target for the treatment of Wnt2B-overexpressing MPMs.
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Copy and paste a formatted citation
Spandidos Publications style
Kobayashi M, Huang C, Sonobe M, Kikuchi R, Ishikawa M, Kitamura J, Miyahara R, Menju T, Iwakiri S, Itoi K, Itoi K, et al: Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients. Exp Ther Med 3: 952-958, 2012.
APA
Kobayashi, M., Huang, C., Sonobe, M., Kikuchi, R., Ishikawa, M., Kitamura, J. ... Date, H. (2012). Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients. Experimental and Therapeutic Medicine, 3, 952-958. https://doi.org/10.3892/etm.2012.511
MLA
Kobayashi, M., Huang, C., Sonobe, M., Kikuchi, R., Ishikawa, M., Kitamura, J., Miyahara, R., Menju, T., Iwakiri, S., Itoi, K., Yasumizu, R., Date, H."Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients". Experimental and Therapeutic Medicine 3.6 (2012): 952-958.
Chicago
Kobayashi, M., Huang, C., Sonobe, M., Kikuchi, R., Ishikawa, M., Kitamura, J., Miyahara, R., Menju, T., Iwakiri, S., Itoi, K., Yasumizu, R., Date, H."Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients". Experimental and Therapeutic Medicine 3, no. 6 (2012): 952-958. https://doi.org/10.3892/etm.2012.511
Copy and paste a formatted citation
x
Spandidos Publications style
Kobayashi M, Huang C, Sonobe M, Kikuchi R, Ishikawa M, Kitamura J, Miyahara R, Menju T, Iwakiri S, Itoi K, Itoi K, et al: Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients. Exp Ther Med 3: 952-958, 2012.
APA
Kobayashi, M., Huang, C., Sonobe, M., Kikuchi, R., Ishikawa, M., Kitamura, J. ... Date, H. (2012). Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients. Experimental and Therapeutic Medicine, 3, 952-958. https://doi.org/10.3892/etm.2012.511
MLA
Kobayashi, M., Huang, C., Sonobe, M., Kikuchi, R., Ishikawa, M., Kitamura, J., Miyahara, R., Menju, T., Iwakiri, S., Itoi, K., Yasumizu, R., Date, H."Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients". Experimental and Therapeutic Medicine 3.6 (2012): 952-958.
Chicago
Kobayashi, M., Huang, C., Sonobe, M., Kikuchi, R., Ishikawa, M., Kitamura, J., Miyahara, R., Menju, T., Iwakiri, S., Itoi, K., Yasumizu, R., Date, H."Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients". Experimental and Therapeutic Medicine 3, no. 6 (2012): 952-958. https://doi.org/10.3892/etm.2012.511
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