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Article

Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer

  • Authors:
    • Meng Wang
    • Bao-Gang Liu
    • Zhao-Yang Yang
    • Xuan Hong
    • Gong-Yan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Third Affiliated Hospital of Harbin Medical University, Harbin 150086, P.R. China
  • Pages: 983-988
    |
    Published online on: March 12, 2012
       https://doi.org/10.3892/etm.2012.512
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Abstract

This study was designed to determine the levels of survivin expression and identify its clinical significance as a prognostic factor for stage III non-small cell lung cancer (NSCLC). A total of 210 cases of stage III NSCLC were collected and the expression levels of survivin and vascular endothelial growth factor A (VEGF-A) in tumor tissues were investigated using immunohistochemistry (IHC). The medical records of the patients were reviewed to determine the association with clinical course. Of the 210 NSCLC tissues, 112 (53.3%) cases demonstrated positive expression of survivin protein. Coexpression of survivin and VEGF-A was identified. The 5-year survival rate of patients with positive survivin expression was significantly lower compared with the survivin-negative cancer patients (P<0.05). The expression of survivin in NSCLC correlated with tumor size. Survivin and VEGF-A were independent prognostic factors of stage III NSCLC. Survivin protein is a valuable marker of prognosis in stage III NSCLC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wang M, Liu B, Yang Z, Hong X and Chen G: Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer. Exp Ther Med 3: 983-988, 2012.
APA
Wang, M., Liu, B., Yang, Z., Hong, X., & Chen, G. (2012). Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer. Experimental and Therapeutic Medicine, 3, 983-988. https://doi.org/10.3892/etm.2012.512
MLA
Wang, M., Liu, B., Yang, Z., Hong, X., Chen, G."Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer". Experimental and Therapeutic Medicine 3.6 (2012): 983-988.
Chicago
Wang, M., Liu, B., Yang, Z., Hong, X., Chen, G."Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer". Experimental and Therapeutic Medicine 3, no. 6 (2012): 983-988. https://doi.org/10.3892/etm.2012.512
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Liu B, Yang Z, Hong X and Chen G: Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer. Exp Ther Med 3: 983-988, 2012.
APA
Wang, M., Liu, B., Yang, Z., Hong, X., & Chen, G. (2012). Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer. Experimental and Therapeutic Medicine, 3, 983-988. https://doi.org/10.3892/etm.2012.512
MLA
Wang, M., Liu, B., Yang, Z., Hong, X., Chen, G."Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer". Experimental and Therapeutic Medicine 3.6 (2012): 983-988.
Chicago
Wang, M., Liu, B., Yang, Z., Hong, X., Chen, G."Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer". Experimental and Therapeutic Medicine 3, no. 6 (2012): 983-988. https://doi.org/10.3892/etm.2012.512
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