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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June 2012 Volume 3 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression

  • Authors:
    • Jun Li
    • Haifeng Wang
    • Zhen Ma
    • Wenxing Fan
    • Yanfeng  Li
    • Bingbing Han
    • Zhijia Zhang
    • Jiansong Wang

  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First Affiliated Hospital, Kunming Medical University, Kunming 650031, P.R. China, Department of Urology, The Second Affiliated Hospital, Kunming Medical University, Kunming 650101, P.R. China
  • Pages: 1033-1038
    |
    Published online on: March 21, 2012
       https://doi.org/10.3892/etm.2012.520
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Abstract

In order to identify the antitumor effect of TAT-Apoptin on the human bladder cancer EJ cell line and study its impact on the expression of the apoptosis-related genes bax, bcl-2, caspase-3 and survivin, the MTT assay, real-time quantitative PCR and western blot analysis were used in this study. The results of the MTT assay indicated that TAT-Apoptin was able to inhibit the proliferation of EJ cells in a dose-dependent manner. The expression of Bax, Bcl-2, Caspase-3 and Survivin mRNA and protein following the treatment of the EJ cells with TAT-Apoptin (0.1, 0.5, 1, 10, 50 and 100 µg/ml) for 24, 48 and 72 h was analyzed. Cell proliferation was significantly different after treatment with the various concentrations of TAT-Apoptin and the durations of treatment. The level of expression of Bcl-2 and Survivin in EJ cells decreased significantly, while that of Bax and Caspase-3 increased significantly at the mRNA and protein levels.

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Copy and paste a formatted citation
Spandidos Publications style
Li J, Wang H, Ma Z, Fan W, Li Y, Han B, Zhang Z and Wang J: TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression. Exp Ther Med 3: 1033-1038, 2012.
APA
Li, J., Wang, H., Ma, Z., Fan, W., Li, Y., Han, B. ... Wang, J. (2012). TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression. Experimental and Therapeutic Medicine, 3, 1033-1038. https://doi.org/10.3892/etm.2012.520
MLA
Li, J., Wang, H., Ma, Z., Fan, W., Li, Y., Han, B., Zhang, Z., Wang, J."TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression". Experimental and Therapeutic Medicine 3.6 (2012): 1033-1038.
Chicago
Li, J., Wang, H., Ma, Z., Fan, W., Li, Y., Han, B., Zhang, Z., Wang, J."TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression". Experimental and Therapeutic Medicine 3, no. 6 (2012): 1033-1038. https://doi.org/10.3892/etm.2012.520
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Wang H, Ma Z, Fan W, Li Y, Han B, Zhang Z and Wang J: TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression. Exp Ther Med 3: 1033-1038, 2012.
APA
Li, J., Wang, H., Ma, Z., Fan, W., Li, Y., Han, B. ... Wang, J. (2012). TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression. Experimental and Therapeutic Medicine, 3, 1033-1038. https://doi.org/10.3892/etm.2012.520
MLA
Li, J., Wang, H., Ma, Z., Fan, W., Li, Y., Han, B., Zhang, Z., Wang, J."TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression". Experimental and Therapeutic Medicine 3.6 (2012): 1033-1038.
Chicago
Li, J., Wang, H., Ma, Z., Fan, W., Li, Y., Han, B., Zhang, Z., Wang, J."TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression". Experimental and Therapeutic Medicine 3, no. 6 (2012): 1033-1038. https://doi.org/10.3892/etm.2012.520
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