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Article

The TNF-α -308G/A polymorphism is associated with migraine risk: A meta-analysis

  • Authors:
    • Lian Gu
    • Yan Yan
    • Jianxiong Long
    • Li Su
    • Yanling Hu
    • Qing Chen
    • Juanjuan Xie
    • Guangliang Wu
  • View Affiliations / Copyright

    Affiliations: Department of Internal Neurology, First Affiliated Hospital, Guangxi Traditional Chinese Medicine University, Nanning, Guangxi, P.R. China, School of Public Health, Guangxi Medical University, Nanning, Guangxi, P.R. China, Medical Research Center, Guangxi Medical University, Nanning, Guangxi, P.R. China, Guangxi Traditional Chinese Medicine University, Nanning, Guangxi, P.R. China
  • Pages: 1082-1086
    |
    Published online on: March 30, 2012
       https://doi.org/10.3892/etm.2012.533
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Abstract

Migraine is a neurasthenia and the genetic etiology has not been determined. Several studies concerning the correlation between the tumor necrosis factor (TNF)-α -308G/A polymorphism and migraine have been published, but their results remain controversial and the small samples in each study do not allow sufficient statistical power. In the present study, odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association between the polymorphism and migraine. An inverse-variance method was applied to estimate the frequency of the putative risk allele in the controls. Heterogeneity was determined using Cochran's Q test and the inconsistency index (I2). Begg's test and the inverted funnel plot were used to assess the publication bias. Five studies on Asian populations, comprising 985 cases and 958 controls, were included in the meta-analysis. The overall results revealed that the TNF-α -308G/A polymorphism was associated with migraine risk in Asians. The ORs were 1.735 (95% CI, 1.129-2.666) for A vs. G; 1.781 (95% CI, 1.166-2.718) for GA vs. GG; 1.821 (95% CI, 1.153-2.874) for AA+GA vs. GG. The subgroup analysis was based on migraine with aura (MA) and migraine without aura (MO) and there was a statistically significant result for MA [the OR was 1.728 (95% CI, 1.095-2.726) for GA vs. GG and 1.651 (95% CI, 1.049-2.598) for AA+GA vs. GG] but not for MO. In conclusion, the TNF-α -308G/A polymorphism was associated with migraine risk.
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1. 

Haut SR, Bigal ME and Lipton RB: Chronic disorders with episodic manifestations: focus on epilepsy and migraine. Lancet Neurol. 5:148–157. 2006. View Article : Google Scholar : PubMed/NCBI

2. 

Russell MB and Olesen J: Migrainous disorder and its relation to migraine without aura and migraine with aura. A genetic epidemiological study. Cephalalgia. 16:431–435. 1996. View Article : Google Scholar : PubMed/NCBI

3. 

Lipton RB and Stewart WF: Prevalence and impact of migraine. Neurol Clin. 15:1–13. 1997. View Article : Google Scholar

4. 

Stovner L, Hagen K, Jensen R, et al: The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 27:193–210. 2007. View Article : Google Scholar : PubMed/NCBI

5. 

Schurks M, Buring JE and Kurth T: Migraine, migraine features, and cardiovascular disease. Headache. 50:1031–1040. 2010. View Article : Google Scholar : PubMed/NCBI

6. 

Gudmundsson LS, Scher AI, Aspelund T, et al: Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study. BMJ. 341:c39662010. View Article : Google Scholar : PubMed/NCBI

7. 

Goadsby PJ: Pathophysiology of migraine: A disease of the brain. Headache. Goadsby PJ and Silberstein SD: Butterworth-Heinemann; Boston: pp. 5–24. 1997

8. 

Durham PL: Calcitonin gene-related peptide (CGRP) and migraine. Headache. 46(Suppl 1): S3–S8. 2006. View Article : Google Scholar : PubMed/NCBI

9. 

Goadsby PJ, Edvinsson L and Ekman R: Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 28:183–187. 1990. View Article : Google Scholar : PubMed/NCBI

10. 

Carroll MC, Katzman P, Alicot EM, et al: Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes. Proc Natl Acad Sci USA. 84:8535–8539. 1987. View Article : Google Scholar : PubMed/NCBI

11. 

Wilson AG, Giovine FS and Duff GW: Genetics of tumour necrosis factor-alpha in autoimmune, infectious, and neoplastic diseases. J Inflamm. 45:1–12. 1995.PubMed/NCBI

12. 

Yilmaz IA, Ozge A, Erdal ME, Edgünlü TG, Cakmak SE and Yalin OO: Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation. Pain Med. 11:492–497. 2010. View Article : Google Scholar : PubMed/NCBI

13. 

Mazaheri S, Hajilooi M and Rafiei A: The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura. J Neurol. 253:1589–1593. 2006. View Article : Google Scholar : PubMed/NCBI

14. 

Ates O, Kurt S, Altinisik J, Karaer H and Sezer S: Genetic variations in tumor necrosis factor alpha, interleukin-10 genes, and migraine susceptibility. Pain Med. 12:1464–1469. 2011. View Article : Google Scholar : PubMed/NCBI

15. 

Ghosh J, Joshi G, Pradhan S and Mittal B: Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine. J Neurol. 257:898–904. 2010.

16. 

Herken H, Emin EM, Mustafa Y, Kaan S and Yildirim B: The -308 G/A polymorphism of tumor necrosis factor alpha gene is not associated with migraine. Pain Clinic. 17:389–393. 2005. View Article : Google Scholar

17. 

Lee KA, Jang SY, Sohn KM, Won HH, Kim MJ, Kim JW and Chung CS: Association between a polymorphism in the lymphotoxin-a promoter region and migraine. Headache. 47:1056–1062. 2007. View Article : Google Scholar : PubMed/NCBI

18. 

Egger M, Davey Smith G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI

19. 

Petiti DB: Meta-Analysis, Decision Analysis and Cost-Effectiveness Analysis: Methods for Quantitative Synthesis in Medicine. 1st edition. Oxford University Press; New York: 1994

20. 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

21. 

Rainero I, Grimaldi LM, Salani G, Valfrè W, Rivoiro C, Savi L and Pinessi L: Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine. Neurology. 62:141–143. 2004. View Article : Google Scholar : PubMed/NCBI

22. 

Trabace S, Brioli G, Lulli P, Morellini M, Giacovazzo M, Cicciarelli G and Martelletti P: Tumor necrosis factor gene polymorphism in migraine. Headache. 42:341–345. 2002. View Article : Google Scholar : PubMed/NCBI

23. 

Poscente M, Brioli G, Lulli P, Morellini M, Martelletti P, Trabace S and Giacovazzo M: TNFA gene: the -308 promoter polymorphism in migraine. J Headache Pain. 1(Suppl 2): S169–S171. 2000. View Article : Google Scholar

24. 

Asuni C, Stochino ME, Cherchi A, et al: Migraine and tumour necrosis factor gene polymorphism. An association study in a Sardinian sample. J Neurol. 256:194–197. 2009. View Article : Google Scholar : PubMed/NCBI

25. 

Schürks M, Kurth T, Buring JE and Zee RY: A candidate gene association study of 77 polymorphisms in migraine. J Pain. 10:759–766. 2009.PubMed/NCBI

26. 

Russell MB and Olesen J: Increased familial risk and evidence of genetic factor in migraine. BMJ. 311:541–544. 1995. View Article : Google Scholar : PubMed/NCBI

27. 

Russell MB, Ulrich V, Gervil M and Olesen J: Migraine without aura and migraine with aura are distinct disorders. A population-based twin survey. Headache. 42:332–336. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gu L, Yan Y, Long J, Su L, Hu Y, Chen Q, Xie J and Wu G: The TNF-α -308G/A polymorphism is associated with migraine risk: A meta-analysis. Exp Ther Med 3: 1082-1086, 2012.
APA
Gu, L., Yan, Y., Long, J., Su, L., Hu, Y., Chen, Q. ... Wu, G. (2012). The TNF-α -308G/A polymorphism is associated with migraine risk: A meta-analysis. Experimental and Therapeutic Medicine, 3, 1082-1086. https://doi.org/10.3892/etm.2012.533
MLA
Gu, L., Yan, Y., Long, J., Su, L., Hu, Y., Chen, Q., Xie, J., Wu, G."The TNF-α -308G/A polymorphism is associated with migraine risk: A meta-analysis". Experimental and Therapeutic Medicine 3.6 (2012): 1082-1086.
Chicago
Gu, L., Yan, Y., Long, J., Su, L., Hu, Y., Chen, Q., Xie, J., Wu, G."The TNF-α -308G/A polymorphism is associated with migraine risk: A meta-analysis". Experimental and Therapeutic Medicine 3, no. 6 (2012): 1082-1086. https://doi.org/10.3892/etm.2012.533
Copy and paste a formatted citation
x
Spandidos Publications style
Gu L, Yan Y, Long J, Su L, Hu Y, Chen Q, Xie J and Wu G: The TNF-α -308G/A polymorphism is associated with migraine risk: A meta-analysis. Exp Ther Med 3: 1082-1086, 2012.
APA
Gu, L., Yan, Y., Long, J., Su, L., Hu, Y., Chen, Q. ... Wu, G. (2012). The TNF-α -308G/A polymorphism is associated with migraine risk: A meta-analysis. Experimental and Therapeutic Medicine, 3, 1082-1086. https://doi.org/10.3892/etm.2012.533
MLA
Gu, L., Yan, Y., Long, J., Su, L., Hu, Y., Chen, Q., Xie, J., Wu, G."The TNF-α -308G/A polymorphism is associated with migraine risk: A meta-analysis". Experimental and Therapeutic Medicine 3.6 (2012): 1082-1086.
Chicago
Gu, L., Yan, Y., Long, J., Su, L., Hu, Y., Chen, Q., Xie, J., Wu, G."The TNF-α -308G/A polymorphism is associated with migraine risk: A meta-analysis". Experimental and Therapeutic Medicine 3, no. 6 (2012): 1082-1086. https://doi.org/10.3892/etm.2012.533
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