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Article

Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab

  • Authors:
    • Jidong Hong
    • Yuping Peng
    • Yuping Liao
    • Wuzhong Jiang
    • Rui Wei
    • Lei Huo
    • Zaide Han
    • Chaojun Duan
    • Meizuo Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Xiangya Hospital of Central South University, Changsha 410008, P.R. China, Department of Neurosurgery, The Xiangya Hospital of Central South University, Changsha 410008, P.R. China, Department of Radiology, The Xiangya Hospital of Central South University, Changsha 410008, P.R. China, Institute of Medical Sciences, The Xiangya Hospital of Central South University, Changsha 410008, P.R. China
  • Pages: 151-157
    |
    Published online on: April 19, 2012
       https://doi.org/10.3892/etm.2012.555
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Abstract

The present study aimed to determine whether nimotuzumab enhances the effect of radiochemotherapy in malignant gliomas. Patients (n=41) with malignant gliomas were divided into 20 cases (treatment group) in which nimotuzumab plus radiochemotherapy were offered and 21 cases (control group) in which placebo and radiochemotherapy were administered to the patients. The response to treatment was evaluated according to the Response Evaluation Criteria in Solid Tumors, the Kaplan-Meier method was used to calculate the mean and median survival times and 1‑year survival rate, and the log-rank test and the Chi-square test were used to analyze the difference in the survival and response rate between the treatment and control groups. The mean survival times of the treatment and control groups were 14.3 and 10.4 months and the median survival times of the treatment and control groups were 16.5 and 10.5 months, respectively. The 1-year survival rates of the treatment and control groups were 81.3 and 69.1%, respectively, with no significant difference (P>0.05). The objective response rates of the treatment and control groups were 70.0 and 52.4%, respectively, with no significant difference (P>0.05). In conclusion, there was a trend towards improved treatment efficacy of radiochemotherapy combined with nimotuzumab against malignant gliomas. This study demonstrated that the use of nimotuzumab combined with radiotherapy and concomitant temozolomide chemotherapy is effective for malignant gliomas.
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Copy and paste a formatted citation
Spandidos Publications style
Hong J, Peng Y, Liao Y, Jiang W, Wei R, Huo L, Han Z, Duan C and Zhong M: Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab. Exp Ther Med 4: 151-157, 2012.
APA
Hong, J., Peng, Y., Liao, Y., Jiang, W., Wei, R., Huo, L. ... Zhong, M. (2012). Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab. Experimental and Therapeutic Medicine, 4, 151-157. https://doi.org/10.3892/etm.2012.555
MLA
Hong, J., Peng, Y., Liao, Y., Jiang, W., Wei, R., Huo, L., Han, Z., Duan, C., Zhong, M."Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab". Experimental and Therapeutic Medicine 4.1 (2012): 151-157.
Chicago
Hong, J., Peng, Y., Liao, Y., Jiang, W., Wei, R., Huo, L., Han, Z., Duan, C., Zhong, M."Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab". Experimental and Therapeutic Medicine 4, no. 1 (2012): 151-157. https://doi.org/10.3892/etm.2012.555
Copy and paste a formatted citation
x
Spandidos Publications style
Hong J, Peng Y, Liao Y, Jiang W, Wei R, Huo L, Han Z, Duan C and Zhong M: Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab. Exp Ther Med 4: 151-157, 2012.
APA
Hong, J., Peng, Y., Liao, Y., Jiang, W., Wei, R., Huo, L. ... Zhong, M. (2012). Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab. Experimental and Therapeutic Medicine, 4, 151-157. https://doi.org/10.3892/etm.2012.555
MLA
Hong, J., Peng, Y., Liao, Y., Jiang, W., Wei, R., Huo, L., Han, Z., Duan, C., Zhong, M."Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab". Experimental and Therapeutic Medicine 4.1 (2012): 151-157.
Chicago
Hong, J., Peng, Y., Liao, Y., Jiang, W., Wei, R., Huo, L., Han, Z., Duan, C., Zhong, M."Nimotuzumab prolongs survival in patients with malignant gliomas: A phase I/II clinical study of concomitant radiochemotherapy with or without nimotuzumab". Experimental and Therapeutic Medicine 4, no. 1 (2012): 151-157. https://doi.org/10.3892/etm.2012.555
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