Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma

  • Authors:
    • Elmas Kasap
    • Seda Örenay Boyacioglu
    • Mehmet Korkmaz
    • Elif Saritas Yuksel
    • Belkıs Ünsal
    • Erkan Kahraman
    • Ömer Özütemiz
    • Hakan Yuceyar
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  • Published online on: April 25, 2012     https://doi.org/10.3892/etm.2012.561
  • Pages: 33-42
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Abstract

Gastroesophageal reflux disease is a risk factor for esophageal adenocarcinoma yet studies that have investigated the relationship between erosive esophagitis and esophageal adenocarcinoma have usually focused on symptom-related evidence or polymorphisms. There are no epigenetic gene expression studies on this topic. In this study, we aimed to evaluate the relationship between erosive esophagitis and esophageal adenocarcinoma to identify whether there is a genetic predisposition for esophageal adenocarcinoma. The Human Epigenetic Chromatin Modification Enzyme RT2 ProfilerTM PCR array (PAHS-085A) was used to detect the expression of 84 key genes encoding enzymes. This was carried out prospectively for samples from 60 patients (20 patients as a control group, 20 patients with erosive esophagitis and 20 patients with esophageal adenocarcinoma). AURKA, AURKB, NEK6 were expressed at significantly higher levels in esophageal adenocarcinoma compared to the control group. MBD2 was expressed at significantly lower levels in the esophageal adenocarcinoma group compared to the control group. AURKA, AURKC, HDAC9 and NEK6 were expressed at significantly higher levels in erosive esophagitis compared to the control group. There was no difference in upregulated gene expression between the erosive esophagitis and esophageal adenocarcinoma. MBD2 was significantly downregulated in esophageal adenocarcinoma compared to erosive esophagitis. NEK6 and AURKA were significantly upregulated in esophageal adenocarcinoma and erosive esophagitis compared to the control group. This is a novel study on the genetic predisposition for erosive esophagitis and esophageal adenocarcinoma. AURKA and NEK6 are two promising genetic markers for erosive esophagitis and esophageal adenocarcinoma.
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July 2012
Volume 4 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Kasap E, Örenay Boyacioglu S, Korkmaz M, Saritas Yuksel E, Ünsal B, Kahraman E, Özütemiz Ö and Yuceyar H: Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma. Exp Ther Med 4: 33-42, 2012
APA
Kasap, E., Örenay Boyacioglu, S., Korkmaz, M., Saritas Yuksel, E., Ünsal, B., Kahraman, E. ... Yuceyar, H. (2012). Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma. Experimental and Therapeutic Medicine, 4, 33-42. https://doi.org/10.3892/etm.2012.561
MLA
Kasap, E., Örenay Boyacioglu, S., Korkmaz, M., Saritas Yuksel, E., Ünsal, B., Kahraman, E., Özütemiz, Ö., Yuceyar, H."Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma". Experimental and Therapeutic Medicine 4.1 (2012): 33-42.
Chicago
Kasap, E., Örenay Boyacioglu, S., Korkmaz, M., Saritas Yuksel, E., Ünsal, B., Kahraman, E., Özütemiz, Ö., Yuceyar, H."Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma". Experimental and Therapeutic Medicine 4, no. 1 (2012): 33-42. https://doi.org/10.3892/etm.2012.561