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Article

A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer

  • Authors:
    • Sang-Ah Han
    • Jeong-Yoon Song
    • Seon-Young Min
    • Won Seo Park
    • Mi-Ja Kim
    • Joo-Ho Chung
    • Kee Hwan Kwon
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, School of Medicine, Kyung Hee University, Seoul, Republic of Korea, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
  • Pages: 519-523
    |
    Published online on: June 8, 2012
       https://doi.org/10.3892/etm.2012.604
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Abstract

The FOSB gene is involved in cell proliferation, differentiation and transformation in several tumor types. We investigated whether coding single-nucleotide polymorphisms (cSNPs) and promoter SNPs of FOSB contribute to the development of papillary thyroid cancer (PTC). We also assessed the associations between FOSB SNPs and the clinicopathological characteristics of PTC. One coding SNP (rs2282695, Ala39Ala) and one promoter SNP (rs12373539, -158) in the FOSB gene were genotyped using direct sequencing in 94 PTC patients and 213 healthy controls. Genetic data were analyzed using SNPStats, HelixTree and SNPAnalyzer. PTC patients were dichotomized and compared with respect to clinicopathological characteristics of PTC. We detected an association between PTC and cSNP (rs2282695) in FOSB [codominant model 1 (C/C vs. G/C); OR=1.75; 95% CI, 1.04‑2.94; P=0.024; codominant model 2 (C/C vs. G/G): OR=2.55; 95% CI, 1.15‑5.64; P=0.045; dominant model: OR=1.89; 95% CI, 1.16‑3.08; P=0.010; Log‑additive model: OR=1.64; 95% CI, 1.15‑2.35; P=0.007]. The G allele was a risk allele in the genotype and allele analyses of cSNP (rs2282695) in the FOSB gene (OR=1.57; 95% CI, 1.10‑2.24; P=0.012). A promoter SNP (rs12373539) in FOSB was associated with cervical lymph node metastasis of PTC [codominant model 1 (G/G vs. A/G): OR=0.23; 95% CI, 0.07‑0.72; P=0.016; codominant model 2 (G/G vs. A/A): OR=0.21; 95% CI, 0.02‑1.96; P=0.0.05; dominant model: OR=0.22; 95% CI, 0.08‑0.66; P=0.004; overdominant model: OR=0.27; 95% CI, 0.09‑0.84; P=0.02; log‑additive model: OR=0.31; 95% CI, 0.12‑0.78; P=0.006]. The A allele was a protective allele in the genotype and allele analyses of SNP (rs12373539) in the FOSB gene promoter (OR=0.34; 95% CI, 0.14‑0.83; P=0.017). Variation in a FOSB cSNP (rs2282695) may be associated with risk of PTC. The FOSB promoter SNP (rs12373539) may be associated with lymph node metastasis of PTC.
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1. 

Davies L and Welch HG: Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA. 295:2164–2167. 2006.

2. 

National Cancer Information Center, Goyang: National cancer statistics. http://www.cancer.go.kr/cms/statics/incidence/index.html#2uri (Accessed June 2011).

3. 

Goldgar DE, Easton DF, Cannon-Albright LA and Skolnick MH: Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst. 86:1600–1608. 1994. View Article : Google Scholar : PubMed/NCBI

4. 

Czene K, Lichtenstein P and Hemminki K: Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database. Int J Cancer. 99:260–266. 2002. View Article : Google Scholar : PubMed/NCBI

5. 

Canzian F, Amati P, Harach HR, et al: A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2. Am J Hum Genet. 63:1743–1748. 1998. View Article : Google Scholar : PubMed/NCBI

6. 

McKay JD, Lesueur F, Jonard L, et al: Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21. Am J Hum Genet. 69:440–446. 2001. View Article : Google Scholar : PubMed/NCBI

7. 

U.S. National Library of Medicine, Bethesda: FOSB FBJ murine osteosarcoma viral oncogene homolog B. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2354uri (Accessed September 2011).

8. 

Siderovski DP, Blum S, Forsdyke RE and Forsdyke DR: A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes. DNA Cell Biol. 9:579–587. 1990. View Article : Google Scholar

9. 

Martin-Gallardo A, McCombie WR, Gocayne JD, et al: Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. Nat Genet. 1:34–39. 1992. View Article : Google Scholar : PubMed/NCBI

10. 

Hess J, Angel P and Schorpp-Kistner M: AP-1 subunits: quarrel and harmony among siblings. J Cell Sci. 117:5965–5973. 2004. View Article : Google Scholar : PubMed/NCBI

11. 

Ameyar M, Wisniewska M and Weitzman JB: A role for AP-1 in apoptosis: the case for and against. Biochimie. 85:747–752. 2003. View Article : Google Scholar : PubMed/NCBI

12. 

Adjadj E, Schlumberger M and de Vathaire F: Germ-line DNA polymorphisms and susceptibility to differentiated thyroid cancer. Lancet Oncol. 10:181–190. 2009. View Article : Google Scholar : PubMed/NCBI

13. 

Siraj AK, Al-Rasheed M, Ibrahim M, et al: RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population. J Endocrinol Invest. 31:893–899. 2008. View Article : Google Scholar : PubMed/NCBI

14. 

Baida A, Farrington SM, Galofre P, Marcos R and Velazquez A: Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. Cancer Epidemiol Biomarkers Prev. 14:638–642. 2005. View Article : Google Scholar : PubMed/NCBI

15. 

Eun YG, Hong IK, Kim SK, et al: A polymorphism (rs1801018, Thr7Thr) of BCL2 is associated with papillary thyroid cancer in Korean population. Clin Exp Otorhinolaryngol. 4:149–154. 2011. View Article : Google Scholar : PubMed/NCBI

16. 

Choi SJ, Kim TY, Lee JC, et al: Is routine central neck dissection necessary for the treatment of papillary thyroid microcarcinoma? Clin Exp Otorhinolaryngol. 1:41–45. 2008. View Article : Google Scholar : PubMed/NCBI

17. 

Zerial M, Toschi L, Ryseck RP, Schuermann M, Muller R and Bravo R: The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J. 8:805–813. 1989.PubMed/NCBI

18. 

Mumberg D, Lucibello FC, Schuermann M and Muller R: Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins. Genes Dev. 5:1212–1223. 1991. View Article : Google Scholar

19. 

Metz R, Kouzarides T and Bravo R: A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding protein, is required for altered cell growth. EMBO J. 13:3832–3842. 1994.PubMed/NCBI

20. 

Angel P and Karin M: The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta. 1072:129–157. 1991.PubMed/NCBI

21. 

Karin M, Liu Z and Zandi E: AP-1 function and regulation. Curr Opin Cell Biol. 9:240–246. 1997. View Article : Google Scholar

22. 

Ransone LJ, Visvader J, Lamph WW, Sassone-Corsi P and Verma IM: fos and jun interaction: the role of the leucine zipper. Int J Cancer Suppl. 4:10–21. 1989. View Article : Google Scholar : PubMed/NCBI

23. 

Shaulian E and Karin M: AP-1 in cell proliferation and survival. Oncogene. 20:2390–2400. 2001. View Article : Google Scholar : PubMed/NCBI

24. 

Van Dam H and Castellazzi M: Distinct roles of Jun: Fos and Jun: ATF dimers in oncogenesis. Oncogene. 20:2453–2464. 2001.PubMed/NCBI

25. 

Lee W, Mitchell P and Tjian R: Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell. 49:741–752. 1987. View Article : Google Scholar : PubMed/NCBI

26. 

Vallone D, Battista S, Pierantoni GM, et al: Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product. EMBO J. 16:5310–5321. 1997. View Article : Google Scholar : PubMed/NCBI

27. 

Liu G, Takano T, Matsuzuka F, Higashiyama T, Kuma K and Amino N: Screening of specific changes in mRNAs in thyroid tumors by sequence specific differential display: decreased expression of c-fos mRNA in papillary carcinoma. Endocr J. 46:459–466. 1999. View Article : Google Scholar

28. 

Chiappetta G, Tallini G, De Biasio MC, et al: FRA-1 expression in hyperplastic and neoplastic thyroid diseases. Clin Cancer Res. 6:4300–4306. 2000.PubMed/NCBI

29. 

Kim YH, Oh JH, Kim NH, et al: Fra-1 expression in malignant and benign thyroid tumor. Korean J Intern Med. 16:93–97. 2001.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han S, Song J, Min S, Park WS, Kim M, Chung J and Kwon KH: A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer. Exp Ther Med 4: 519-523, 2012.
APA
Han, S., Song, J., Min, S., Park, W.S., Kim, M., Chung, J., & Kwon, K.H. (2012). A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer. Experimental and Therapeutic Medicine, 4, 519-523. https://doi.org/10.3892/etm.2012.604
MLA
Han, S., Song, J., Min, S., Park, W. S., Kim, M., Chung, J., Kwon, K. H."A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer". Experimental and Therapeutic Medicine 4.3 (2012): 519-523.
Chicago
Han, S., Song, J., Min, S., Park, W. S., Kim, M., Chung, J., Kwon, K. H."A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer". Experimental and Therapeutic Medicine 4, no. 3 (2012): 519-523. https://doi.org/10.3892/etm.2012.604
Copy and paste a formatted citation
x
Spandidos Publications style
Han S, Song J, Min S, Park WS, Kim M, Chung J and Kwon KH: A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer. Exp Ther Med 4: 519-523, 2012.
APA
Han, S., Song, J., Min, S., Park, W.S., Kim, M., Chung, J., & Kwon, K.H. (2012). A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer. Experimental and Therapeutic Medicine, 4, 519-523. https://doi.org/10.3892/etm.2012.604
MLA
Han, S., Song, J., Min, S., Park, W. S., Kim, M., Chung, J., Kwon, K. H."A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer". Experimental and Therapeutic Medicine 4.3 (2012): 519-523.
Chicago
Han, S., Song, J., Min, S., Park, W. S., Kim, M., Chung, J., Kwon, K. H."A genetic association analysis of polymorphisms, rs2282695 and rs12373539, in the FOSB gene and papillary thyroid cancer". Experimental and Therapeutic Medicine 4, no. 3 (2012): 519-523. https://doi.org/10.3892/etm.2012.604
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