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Article

Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen β chain genes with human abdominal aortic aneurysm

  • Authors:
    • Katarzyna Oszajca
    • Konrad Wroński
    • Grażyna Janiszewska
    • Małgorzata Bieńkiewicz
    • Michał Panek
    • Jacek Bartkowiak
    • Janusz Szemraj
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biochemistry, Medical University of Lodz, Lodz 90-419, Poland, General and Vascular Surgery Department, M. Pirogow Regional Specialist Hospital, Lodz 90-531, Poland , Department of Quality Control and Radiological Protection, Medical University of Lodz, Lodz 92-216, Poland , Department of Internal Diseases, Asthma and Allergy, Medical University of Lodz, Lodz 90-153, Poland
  • Pages: 514-518
    |
    Published online on: June 12, 2012
       https://doi.org/10.3892/etm.2012.608
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Abstract

Increased activity of the coagulation system is associated with the increased risk of many arterial thrombotic diseases and atherosclerosis. The purpose of this study was to evaluate the influence of selected polymorphisms in genes coding for coagulation factor V (1691 G/A, the so-called Leiden mutation), factor VII (-323 0/10 bp insertion/deletion) and fibrinogen β chain (-455 G/A) on the risk of abdominal aortic aneurysm, a particular form of atherothrombosis. We conducted a case-control study of 153 Polish patients hospitalized due to abdominal aortic aneurysm (AAA) and compared the results to those obtained from matched healthy control subjects. The polymorphisms were ascertained through genotyping by polymerase chain reaction and restriction digestion of amplified fragments. The study revealed that individuals carrying heterozygous genotype GA for the fibrinogen β chain -455 G/A mutation had at least a 2-fold greater likelihood of AAA development compared to control subjects (OR=3.01; 95% CI 1.83-4.96). The cases possessing homozygous mutant genotype (AA) had no significant risk of developing AAA compared to the control subjects (OR=1.12; 95% CI 0.33-2.44; p=0.83). Concerning factor V 1691 G/A and factor VII -323 0/10 bp mutations, we did not find any statistically significant correlation between them and AAA occurrence. In conclusion, we suggest that the -455G/A polymorphism of the fibrinogen β chain gene is a potential genetic marker to identify the risk of AAA.
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1. 

Hultgren R, Granath F and Swedenborg J: Different disease profiles for women and men with abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 33:556–560. 2007. View Article : Google Scholar : PubMed/NCBI

2. 

Michel JB, Martin-Ventura JL, Egido J, et al: Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans. Cardiovasc Res. 90:18–27. 2011. View Article : Google Scholar : PubMed/NCBI

3. 

Sakalihasan N, Limet R and Defawe OD: Abdominal aortic aneurysm. Lancet. 365:1577–1589. 2005. View Article : Google Scholar : PubMed/NCBI

4. 

Pajič T: Factor V Leiden and FII 20210 testing in thromboembolic disorders. Clin Chem Lab Med. 48(Suppl 1): 79–87. 2010.PubMed/NCBI

5. 

Bos MHA and Camire RM: Blood coagulation factors V and VIII: molecular mechanisms of procofactor activation. J Coagul Disord. 2:19–27. 2010.PubMed/NCBI

6. 

Vos HL: Inherited defects of coagulation factor V: the thrombotic side. J Thromb Haemost. 4:35–40. 2006. View Article : Google Scholar : PubMed/NCBI

7. 

Griffin JH, Evatt B, Wideman C and Fernandez JA: Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood. 82:1989–1993. 1993.PubMed/NCBI

8. 

Koster T, Rosendaal FR, de Ronde H, Briet E, Vandenbroucke JP and Bertina RM: Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet. 342:1503–1506. 1993. View Article : Google Scholar : PubMed/NCBI

9. 

Bauer KA: Activation of the factor VII-tissue factor pathway. Thromb Haemost. 78:108–111. 1997.PubMed/NCBI

10. 

Humphries S, Temple A, Lane A, Green F, Cooper J and Miller G: Low plasma levels of factor VIIc and antigen are more strongly associated with the 10 base pair promoter (−323) insertion than the glutamine 353 variant. Thromb Haemost. 75:567–572. 1996.PubMed/NCBI

11. 

Shimokata K, Kondo T, Ohno M, et al: Effects of coagulation Factor VII polymorphisms on the coronary artery disease in Japanese: Factor VII polymorphism and coronary disease. Thromb Res. 105:493–498. 2002. View Article : Google Scholar : PubMed/NCBI

12. 

Marino MW, Fuller GM and Elder FF: Chromosomal localization of human and rat A alpha, B beta, and gamma fibrinogen genes by in situ hybridization. Cytogenet Cell Genet. 42:36–41. 1986. View Article : Google Scholar : PubMed/NCBI

13. 

Lee SH, Kim MK, Park MS, Choi SM, Kim JT, Kim BC and Cho KH: Beta-fibrinogen gene −455 G/A polymorphism in Korean ischemic stroke patients. J Clin Neurol. 4:17–22. 2008.

14. 

Pongrácz E, Andrikovics H, Csornai M, Bernát IS and Nagy Z: Contribution of the −455G/A polymorphism at beta-fibrinogen gene and of the Leiden mutation to hemorheological parameters in ischemic stroke patients. Clin Hemorheol Microcirc. 35:75–82. 2006.

15. 

Renner W, Cichocki L, Forjanics A, Köppel H, Gasser R and Pilger E: G-455A polymorphism of the fibrinogen beta gene and deep vein thrombosis. Eur J Clin Invest. 32:755–758. 2002. View Article : Google Scholar : PubMed/NCBI

16. 

Voetsch B and Loscalzo J: Genetic determinants of arterial thrombosis. Arterioscler Thromb Vasc Biol. 24:216–229. 2004. View Article : Google Scholar : PubMed/NCBI

17. 

Lee AJ, Fowkes FG, Lowe GD and Rumley A: Haemostatic factors, atherosclerosis and risk of abdominal aortic aneurysm. Blood Coagul Fibrinolysis. 7:695–701. 1996. View Article : Google Scholar : PubMed/NCBI

18. 

Takagi H, Manabe H, Kawai N, Goto S and Umemoto T: Plasma fibrinogen and D-dimer concentrations are associated with the presence of abdominal aortic aneurysm: a systematic review and meta-analysis. Eur J Vasc Endovasc Surg. 38:273–277. 2009. View Article : Google Scholar : PubMed/NCBI

19. 

Lee AJ, Fowkes FG, Lowe GD, Connor JM and Rumley A: Fibrinogen, factor VII and PAI-1 genotypes and the risk of coronary and peripheral atherosclerosis. Edinburgh Artery Study Thromb Haemost. 81:553–560. 1999.PubMed/NCBI

20. 

de Maat MP, Kastelein JJ, Jukema JW, et al: −455G/A polymorphism of the beta-fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. REGRESS group. Arterioscler Thromb Vasc Biol. 18:265–271. 1998.

21. 

Martiskainen M, Pohjasvaara T, Mikkelsson J, et al: Fibrinogen gene promoter −455 A allele as a risk factor for lacunar stroke. Stroke. 34:886–891. 2003.

22. 

Bozdemir V, Kirimli O, Akdeniz B, et al: The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. Anadolu Kardiyol Derg. 10:209–215. 2010. View Article : Google Scholar : PubMed/NCBI

23. 

van ‘t Hooft FM, von Bahr SJ, Silveira A, Iliadou A, Eriksson P and Hamsten A: Two common, functional polymorphisms in the promoter region of the beta-fibrinogen gene contribute to regulation of plasma fibrinogen concentration. Arterioscler Thromb Vasc Biol. 19:3063–3070. 1999.PubMed/NCBI

24. 

Leander K, Wiman B, Hallqvist J, Falk G and De Faire U: The G-455A polymorphism of the fibrinogen Bbeta-gene relates to plasma fibrinogen in male cases, but does not interact with environmental factors in causing myocardial infarction in either men or women. J Intern Med. 252:332–341. 2002. View Article : Google Scholar

25. 

Iacoviello L, Vischetti M, Zito F and Benedetta Donati M: Genes encoding fibrinogen and cardiovascular risk. Hypertension. 38:1199–1203. 2001. View Article : Google Scholar : PubMed/NCBI

26. 

Green D, Foiles N, Chan C, Schreiner PJ and Liu K: Elevated fibrinogen levels and subsequent subclinical atherosclerosis: the CARDIA Study. Atherosclerosis. 202:623–331. 2009. View Article : Google Scholar : PubMed/NCBI

27. 

Rallidis LS, Gialeraki A, Fountoulaki K, et al: G-455A polymorphism of beta-fibrinogen gene and the risk of premature myocardial infarction in Greece. Thromb Res. 125:34–37. 2010. View Article : Google Scholar : PubMed/NCBI

28. 

Brown ET and Fuller GM: Detection of a complex that associates with the Bβ fibrinogen G-455- A polymorphism. Blood. 92:3286–3293. 1998.

29. 

Singh K, Bønaa KH, Jacobsen BK, Bjørk L and Solberg S: Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study: The Tromsø Study. Am J Epidemiol. 154:236–244. 2001.PubMed/NCBI

30. 

Al-Barjas HS, Ariëns R, Grant P and Scott JA: Raised plasma fibrinogen concentration in patients with abdominal aortic aneurysm. Angiology. 57:607–614. 2006. View Article : Google Scholar : PubMed/NCBI

31. 

Fowkes FG, Anandan CL, Lee AJ, et al: Reduced lung function in patients with abdominal aortic aneurysm is associated with activation of inflammation and hemostasis, not smoking or cardiovascular disease. J Vasc Surg. 43:474–480. 2006. View Article : Google Scholar : PubMed/NCBI

32. 

Spring S, van der Loo B, Krieger E, Amann-Vesti BR, Rousson V and Koppensteiner R: Decreased wall shear stress in the common carotid artery of patients with peripheral arterial disease or abdominal aortic aneurysm: relation to blood rheology, vascular risk factors, and intima-media thickness. J Vasc Surg. 43:56–63. 2006. View Article : Google Scholar

33. 

Sofi F, Marcucci R, Giusti B, et al: High levels of homocysteine, lipoprotein (a) and plasminogen activator inhibitor-1 are present in patients with abdominal aortic aneurysm. Thromb Haemost. 94:1094–1098. 2005.PubMed/NCBI

34. 

Ioannou HV, Mitsis M, Eleftheriou A, et al: The prevalence of factor V Leiden as a risk factor for venous thromboembolism in the population of North-Western Greece. Int Angiol. 19:314–318. 2000.PubMed/NCBI

35. 

Juul K, Tybjaerg-Hansen A, Schnohr P and Nordestgaard BG: Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann Intern Med. 140:330–337. 2004. View Article : Google Scholar : PubMed/NCBI

36. 

Sofi F, Lar B, Rogolino A, et al: Thrombophilic risk factors for symptomatic peripheral arterial disease. J Vasc Surg. 41:255–260. 2005. View Article : Google Scholar : PubMed/NCBI

37. 

Reny JL, Alhenc-Gelas M, Fontana P, et al: The factor II G20210A gene polymorphism, but not factor V Arg506Gln, is associated with peripheral arterial disease: results of a case-control study. J Thromb Haemost. 2:1334–1340. 2004. View Article : Google Scholar : PubMed/NCBI

38. 

Renner W, Köppel H, Brodmann M, et al: Factor II G20210A and factor V G1691A gene mutations and peripheral arterial occlusive disease. Thromb Haemost. 83:20–22. 2000.PubMed/NCBI

39. 

März W, Seydewitz H, Winkelmann B, Chen M, Nauck M and Witt I: Mutation in coagulation factor V associated with resistance to activated protein C in patients with coronary artery disease. Lancet. 345:526–527. 1995.PubMed/NCBI

40. 

Rosendaal FR, Siscovick DS, Schwartz SM, et al: Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood. 89:2817–2821. 1997.PubMed/NCBI

41. 

Liu Y, Hengen CK, Saha N, Hong S and Low PS: Genotype associations of factor VII gene with plasma factor VII coagulant activity and antigen levels in healthy Chinese. Blood Coagul Fibrinolysis. 13:217–224. 2002. View Article : Google Scholar : PubMed/NCBI

42. 

Sacchi E, Tagliabue L, Scoglio R, Baroncini C, Coppola R, Bernardi F and Mannucci PM: Plasma factor VII levels are influenced by a polymorphism in the promoter region of the FVII gene. Blood Coagul Fibrinolysis. 7:114–117. 1996. View Article : Google Scholar : PubMed/NCBI

43. 

Mtiraoui N, Aboud N, Bouraoui H, et al: Reduction in coagulation factor VII plasma levels by R353Q but not the −323P0/10 promoter polymorphism in healthy Tunisians. Am J Hematol. 79:11–16. 2005.

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Copy and paste a formatted citation
Spandidos Publications style
Oszajca K, Wroński K, Janiszewska G, Bieńkiewicz M, Panek M, Bartkowiak J and Szemraj J: Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen β chain genes with human abdominal aortic aneurysm. Exp Ther Med 4: 514-518, 2012.
APA
Oszajca, K., Wroński, K., Janiszewska, G., Bieńkiewicz, M., Panek, M., Bartkowiak, J., & Szemraj, J. (2012). Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen β chain genes with human abdominal aortic aneurysm. Experimental and Therapeutic Medicine, 4, 514-518. https://doi.org/10.3892/etm.2012.608
MLA
Oszajca, K., Wroński, K., Janiszewska, G., Bieńkiewicz, M., Panek, M., Bartkowiak, J., Szemraj, J."Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen β chain genes with human abdominal aortic aneurysm". Experimental and Therapeutic Medicine 4.3 (2012): 514-518.
Chicago
Oszajca, K., Wroński, K., Janiszewska, G., Bieńkiewicz, M., Panek, M., Bartkowiak, J., Szemraj, J."Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen β chain genes with human abdominal aortic aneurysm". Experimental and Therapeutic Medicine 4, no. 3 (2012): 514-518. https://doi.org/10.3892/etm.2012.608
Copy and paste a formatted citation
x
Spandidos Publications style
Oszajca K, Wroński K, Janiszewska G, Bieńkiewicz M, Panek M, Bartkowiak J and Szemraj J: Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen β chain genes with human abdominal aortic aneurysm. Exp Ther Med 4: 514-518, 2012.
APA
Oszajca, K., Wroński, K., Janiszewska, G., Bieńkiewicz, M., Panek, M., Bartkowiak, J., & Szemraj, J. (2012). Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen β chain genes with human abdominal aortic aneurysm. Experimental and Therapeutic Medicine, 4, 514-518. https://doi.org/10.3892/etm.2012.608
MLA
Oszajca, K., Wroński, K., Janiszewska, G., Bieńkiewicz, M., Panek, M., Bartkowiak, J., Szemraj, J."Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen β chain genes with human abdominal aortic aneurysm". Experimental and Therapeutic Medicine 4.3 (2012): 514-518.
Chicago
Oszajca, K., Wroński, K., Janiszewska, G., Bieńkiewicz, M., Panek, M., Bartkowiak, J., Szemraj, J."Association analysis of genetic polymorphisms of factor V, factor VII and fibrinogen β chain genes with human abdominal aortic aneurysm". Experimental and Therapeutic Medicine 4, no. 3 (2012): 514-518. https://doi.org/10.3892/etm.2012.608
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