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Article

Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases

  • Authors:
    • Gi-Sang Bae
    • Kyoung-Chel Park
    • Bon Soon Koo
    • Il-Joo Jo
    • Sun  Bok Choi
    • Ho-Joon Song
    • Sung-Joo Park
  • View Affiliations / Copyright

    Affiliations: Hanbang Body-Fluid Research Center, Wonkwang University, Iksan, Jeonbuk 540-749, Republic of Korea, Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 540-749, Republic of Korea
  • Pages: 533-537
    |
    Published online on: June 18, 2012
       https://doi.org/10.3892/etm.2012.612
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Abstract

Previously, we reported that Nardostachys jatamansi (NJ) attenuated cerulein-induced mild acute pancreatitis (AP). In the present study, we investigated the ability of NJ to ameliorate severe acute pancreatitis (SAP) induced by a choline-deficient diet supplemented with ethionine (CDE). An NJ extract was orally administered ad libitum via the water during administration of the CDE. After three days, the CDE was replaced with a normal diet. After four days of normal feeding the mice were sacrificed and the blood and pancreas were obtained for further investigation. NJ treatment reduced SAP-induced pancreatic damage, as shown by histology. NJ treatment also inhibited neutrophil infiltration into the pancreas. NJ also inhibited the secretion of digestive enzymes and cytokine production, and inhibited the activation of mitogen‑activated protein kinases (MAPKs) in the SAP-challenged pancreas. These data suggest that NJ protects against pancreatic injury in CDE-induced SAP by deactivating MAPKs.
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Copy and paste a formatted citation
Spandidos Publications style
Bae G, Park K, Koo BS, Jo I, Choi SB, Song H and Park S: Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases. Exp Ther Med 4: 533-537, 2012.
APA
Bae, G., Park, K., Koo, B.S., Jo, I., Choi, S.B., Song, H., & Park, S. (2012). Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases. Experimental and Therapeutic Medicine, 4, 533-537. https://doi.org/10.3892/etm.2012.612
MLA
Bae, G., Park, K., Koo, B. S., Jo, I., Choi, S. B., Song, H., Park, S."Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases". Experimental and Therapeutic Medicine 4.3 (2012): 533-537.
Chicago
Bae, G., Park, K., Koo, B. S., Jo, I., Choi, S. B., Song, H., Park, S."Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases". Experimental and Therapeutic Medicine 4, no. 3 (2012): 533-537. https://doi.org/10.3892/etm.2012.612
Copy and paste a formatted citation
x
Spandidos Publications style
Bae G, Park K, Koo BS, Jo I, Choi SB, Song H and Park S: Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases. Exp Ther Med 4: 533-537, 2012.
APA
Bae, G., Park, K., Koo, B.S., Jo, I., Choi, S.B., Song, H., & Park, S. (2012). Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases. Experimental and Therapeutic Medicine, 4, 533-537. https://doi.org/10.3892/etm.2012.612
MLA
Bae, G., Park, K., Koo, B. S., Jo, I., Choi, S. B., Song, H., Park, S."Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases". Experimental and Therapeutic Medicine 4.3 (2012): 533-537.
Chicago
Bae, G., Park, K., Koo, B. S., Jo, I., Choi, S. B., Song, H., Park, S."Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases". Experimental and Therapeutic Medicine 4, no. 3 (2012): 533-537. https://doi.org/10.3892/etm.2012.612
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