Association between the CTLA-4 +49A/G polymorphism and Graves' disease: A meta-analysis

  • Authors:
    • Xiaoyu Si
    • Xiufeng Zhang
    • Wenru Tang
    • Ying Luo
  • View Affiliations

  • Published online on: June 20, 2012     https://doi.org/10.3892/etm.2012.618
  • Pages: 538-544
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Abstract

The +49A/G polymorphism of the cytotoxic T-lymphocyte-associated antigen-4 gene (CTLA-4) has been associated with Graves' disease (GD). However, results have been inconsistent. The aim of this study was to quantitatively summarize the evidence for CTLA-4 +49A/G polymorphism and GD. Electronic search of PubMed was conducted to select studies. Case-control studies containing available genotype frequencies of CTLA-4 +49 were chosen, and οdds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Forty-two case-control studies including 8,288 cases and 9,372 controls were identified. Three studies were eliminated from the total 42 studies due to a p-value <0.05 (p-value for Hardy-Weinberg equilibrium in control group) in these studies which induced significant publication bias. The overall results suggested that the variant genotypes were highly associated (p<0.01) with GD risk in all genetic models (additive model: OR, 1.443; 95% CI, 1.319-1.578; p<0.001; recessive model: OR, 1.589; 95% CI, 1.396-1.808; p<0.001; dominant model: OR, 1.621; 95% CI, 1.430-1.837; p<0.001). Similarly, in the subgroup analyses for ethnicity (Caucasian, Asian), the results were positive. This meta-analysis suggests that the CTLA-4 +49A/G polymorphism is highly associated (p<0.01) with increased risk of GD, especially in Caucasians and Asians. To validate this association, further studies with larger participants worldwide are needed to examine associations between this polymorphism and GD.
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September 2012
Volume 4 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Si X, Zhang X, Tang W and Luo Y: Association between the CTLA-4 +49A/G polymorphism and Graves' disease: A meta-analysis. Exp Ther Med 4: 538-544, 2012
APA
Si, X., Zhang, X., Tang, W., & Luo, Y. (2012). Association between the CTLA-4 +49A/G polymorphism and Graves' disease: A meta-analysis. Experimental and Therapeutic Medicine, 4, 538-544. https://doi.org/10.3892/etm.2012.618
MLA
Si, X., Zhang, X., Tang, W., Luo, Y."Association between the CTLA-4 +49A/G polymorphism and Graves' disease: A meta-analysis". Experimental and Therapeutic Medicine 4.3 (2012): 538-544.
Chicago
Si, X., Zhang, X., Tang, W., Luo, Y."Association between the CTLA-4 +49A/G polymorphism and Graves' disease: A meta-analysis". Experimental and Therapeutic Medicine 4, no. 3 (2012): 538-544. https://doi.org/10.3892/etm.2012.618