Association of FAS gene polymorphisms with systemic lupus erythematosus: A case-control study and meta-analysis

Lu,Man-Man; Ye,Qian-Ling; Feng,Chen-Chen; Yang,Jie; Zhang,Tao; Li,Jing; Leng,Rui-Xue; Pan,Hai-Feng; Yuan,Hui; Ye,Dong-Qing

doi:10.3892/etm.2012.625

September 2012 Volume 4 Issue 3

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September 2012 Volume 4 Issue 3

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Article

Association of FAS gene polymorphisms with systemic lupus erythematosus: A case-control study and meta-analysis

Authors:
- Man-Man Lu
- Qian-Ling Ye
- Chen-Chen Feng
- Jie Yang
- Tao Zhang
- Jing Li
- Rui-Xue Leng
- Hai-Feng Pan
- Hui Yuan
- Dong-Qing Ye
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Affiliations: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, P.R. China , The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China , Anhui Center for Disease Control and Prevention, Hefei, Anhui 230601, P.R. China, Department of Preventive Medicine, Wannan Medical College, Wuhu, Anhui 241002, P.R. China, Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, Hefei, Anhui 230032, P.R. China
Pages: 497-502
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Published online on: June 28, 2012

https://doi.org/10.3892/etm.2012.625
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Abstract

The association of functional polymorphisms in the promoter of the apoptosis gene FAS with systemic lupus erythematosus (SLE) susceptibility has been a controversial subject. We conducted a case-control study to investigate this association in a Chinese population and performed a meta-analysis in different populations. The single nucleotide polymorphisms (SNPs) rs2234767 (-1377G>A) and rs1800682 (-670A>G) were genotyped by TaqMan allelic discrimination assays in 552 Chinese SLE patients and 718 healthy controls. In our case-control study, we observed allelic association between the promoter SNP rs2234767 [P=0.033, odds ratio (OR)=0.836, 95% confidence interval (CI), 0.709-0.986] and SLE but not the SNP rs1800682. Haplotype analysis revealed that one haplotype of GA was significantly associated with the disease (P=0.039, OR=1.184, 95% CI, 1.009-1.391). In the meta‑analysis available studies, including our data, were combined using the STATA software package v.7.0. The meta-analysis revealed a significant association between FAS polymorphisms and SLE (rs2234767 A vs. G allele; P=0.004, OR=0.819, 95% CI, 0.715-0.938, rs1800682 G vs. A allele: P=0.034, OR=0.791, 95% CI, 0.637-0.983). In conclusion, FAS gene polymorphisms may contribute to SLE susceptibility in the Chinese population, and the meta-analysis shows that FAS polymorphisms may be associated with SLE susceptibility in different populations.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association of FAS gene polymorphisms with systemic lupus erythematosus: A case-control study and meta-analysis

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