Association of FAS gene polymorphisms with systemic lupus erythematosus: A case-control study and meta-analysis

  • Authors:
    • Man-Man Lu
    • Qian-Ling Ye
    • Chen-Chen Feng
    • Jie Yang
    • Tao Zhang
    • Jing  Li
    • Rui-Xue Leng
    • Hai-Feng Pan
    • Hui Yuan
    • Dong-Qing Ye
  • View Affiliations

  • Published online on: June 28, 2012     https://doi.org/10.3892/etm.2012.625
  • Pages: 497-502
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Abstract

The association of functional polymorphisms in the promoter of the apoptosis gene FAS with systemic lupus erythematosus (SLE) susceptibility has been a controversial subject. We conducted a case-control study to investigate this association in a Chinese population and performed a meta-analysis in different populations. The single nucleotide polymorphisms (SNPs) rs2234767 (-1377G>A) and rs1800682 (-670A>G) were genotyped by TaqMan allelic discrimination assays in 552 Chinese SLE patients and 718 healthy controls. In our case-control study, we observed allelic association between the promoter SNP rs2234767 [P=0.033, odds ratio (OR)=0.836, 95% confidence interval (CI), 0.709-0.986] and SLE but not the SNP rs1800682. Haplotype analysis revealed that one haplotype of GA was significantly associated with the disease (P=0.039, OR=1.184, 95% CI, 1.009-1.391). In the meta‑analysis available studies, including our data, were combined using the STATA software package v.7.0. The meta-analysis revealed a significant association between FAS polymorphisms and SLE (rs2234767 A vs. G allele; P=0.004, OR=0.819, 95% CI, 0.715-0.938, rs1800682 G vs. A allele: P=0.034, OR=0.791, 95% CI, 0.637-0.983). In conclusion, FAS gene polymorphisms may contribute to SLE susceptibility in the Chinese population, and the meta-analysis shows that FAS polymorphisms may be associated with SLE susceptibility in different populations.
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September 2012
Volume 4 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lu M, Ye Q, Feng C, Yang J, Zhang T, Li J, Leng R, Pan H, Yuan H, Ye D, Ye D, et al: Association of FAS gene polymorphisms with systemic lupus erythematosus: A case-control study and meta-analysis. Exp Ther Med 4: 497-502, 2012
APA
Lu, M., Ye, Q., Feng, C., Yang, J., Zhang, T., Li, J. ... Ye, D. (2012). Association of FAS gene polymorphisms with systemic lupus erythematosus: A case-control study and meta-analysis. Experimental and Therapeutic Medicine, 4, 497-502. https://doi.org/10.3892/etm.2012.625
MLA
Lu, M., Ye, Q., Feng, C., Yang, J., Zhang, T., Li, J., Leng, R., Pan, H., Yuan, H., Ye, D."Association of FAS gene polymorphisms with systemic lupus erythematosus: A case-control study and meta-analysis". Experimental and Therapeutic Medicine 4.3 (2012): 497-502.
Chicago
Lu, M., Ye, Q., Feng, C., Yang, J., Zhang, T., Li, J., Leng, R., Pan, H., Yuan, H., Ye, D."Association of FAS gene polymorphisms with systemic lupus erythematosus: A case-control study and meta-analysis". Experimental and Therapeutic Medicine 4, no. 3 (2012): 497-502. https://doi.org/10.3892/etm.2012.625