Predictive value of the pathological extent of tumor invasion in endoscopic resection margins positive for residual tumor cells in surgically resected specimens of early gastric cancer

Tsujimoto,Hironori; Ogata,Sho; Yaguchi,Yoshihisa; Kumano,Isao; Takahata,Risa; Ono,Satoshi; Yamamoto,Junji; Nagao,Shigeaki; Miura,Soichiro; Hase,Kazuo

doi:10.3892/etm.2012.630

September 2012 Volume 4 Issue 3

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September 2012 Volume 4 Issue 3

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Article

Predictive value of the pathological extent of tumor invasion in endoscopic resection margins positive for residual tumor cells in surgically resected specimens of early gastric cancer

Authors:
- Hironori Tsujimoto
- Sho Ogata
- Yoshihisa Yaguchi
- Isao Kumano
- Risa Takahata
- Satoshi Ono
- Junji Yamamoto
- Shigeaki Nagao
- Soichiro Miura
- Kazuo Hase
View Affiliations / Copyright

Affiliations: Department of Surgery, National Defense Medical College, Tokorozawa 359-8513, Japan, Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa 359-8513, Japan, Department of Internal Medicine, National Defense Medical College, Tokorozawa 359-8513, Japan
Pages: 507-513
|
Published online on: July 3, 2012

https://doi.org/10.3892/etm.2012.630
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Abstract

Although endoscopic resection (ER) is considered to be the optimal treatment for early gastric cancer, indications for radical gastrectomy in patients undergoing incomplete ER for early gastric cancer remain unclear. We evaluated the pathological extent of tumor invasion in the ER margins positive for residual tumor cells in the surgically resected specimens. We measured the vertical and/or horizontal length of the exposed tumor in the ER specimens of 23 patients with margins positive for tumor cells. We compared the clinicopathological data to distinguish between the presence and absence of residual tumor cells in the surgically resected specimens. Of 17 lesions with exposed tumor cells in the vertical margins of the ER specimens, only 3 (17.6%) had residual tumor cells in the corresponding site of the surgically resected specimens. By contrast, of 10 lesions with exposed tumor cells in the horizontal margins of the ER specimens, 8 (80.0%) had residual tumor cells in the corresponding site of the surgically resected specimens. The length of the exposed tumor in the vertical margins of the ER specimens was significantly associated with the incidence of residual tumor cells in the vertical margins of the surgically resected specimens. When the cut-off value for the length of the exposed tumor in the vertical ER margins was set to >3 mm, the sensitivity and specificity were 0.67 and 0.95, respectively. In conclusion, measurement of the length of the exposed tumor in the ER margins for early gastric cancer is a simple procedure that is able to determine whether additional surgical intervention is necessary.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Predictive value of the pathological extent of tumor invasion in endoscopic resection margins positive for residual tumor cells in surgically resected specimens of early gastric cancer

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Abstract

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