The -149C>T polymorphism of DNMT3B is not associated with colorectal cancer risk: Evidence from a meta-analysis based on case-control studies

Fang,Chunyan; Sun,Wenqi; Han,Huirong; Shi,Lihong; Wang,Lin; Zhao,Yan; Tan,Yang

doi:10.3892/etm.2012.638

October 2012 Volume 4 Issue 4

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October 2012 Volume 4 Issue 4

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Article

The -149C>T polymorphism of DNMT3B is not associated with colorectal cancer risk: Evidence from a meta-analysis based on case-control studies

Authors:
- Chunyan Fang
- Wenqi Sun
- Huirong Han
- Lihong Shi
- Lin Wang
- Yan Zhao
- Yang Tan
View Affiliations / Copyright

Affiliations: Laboratory of Applied Pharmacology, Weifang Medical University, Weifang 261042, P.R. China, The Fifth People's Hospital of Weifang, Weifang 261000, P.R. China, Department of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Cardiology, Tianjin 300211, P.R. China, Digestive Department of Chongqing First People's Hospital, Chongqing 400011, P.R. China
Pages: 728-732
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Published online on: July 17, 2012

https://doi.org/10.3892/etm.2012.638
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Abstract

The aim of this study was to examine the association between the -149C>T polymorphism of DNA methyltransferase 3B (DNMT3B) and colorectal cancer (CRC) susceptibility. A comprehensive search was conducted to identify all case-control studies of the -149C>T polymorphism of DNMT3B and CRC risk. Statistical analysis was performed with the software program Stata (version 12.0) and Review Manager (version 5.0). A total of seven eligible studies, including 2,666 cases and 4,022 controls, associating the DNMT3B polymorphism of -149C>T with the risk of CRC were identified. These studies suggested no significant associations between the -149C>T polymorphism of the DNMT3B gene and the risk of developing CRC in the recessive, dominant and co-dominant models [for CC vs. TT: odds ratio (OR), 0.90; 95% confidence interval (CI), 0.90-1.25; P=0.37; for the recessive model: OR, 0.54, 95% CI, 0.28-1.04; P﹤0.00001; for the dominant model: OR, 1.07; 95% CI, 0.93-1.23; P=0.83 and C allele vs. T allele: OR, 0.70; 95% CI, 0.43-1.13; P﹤0.00001]. In the subgroup analysis, no significant associations were found in the European populations (for CC vs. TT: OR, 1.09; 95% CI, 0.92-1.30; P=0.88; for the recessive model: OR, 1.00; 95% CI, 0.88-1.13; P=0.14; for the dominant model: OR, 1.50; 95% CI, 0.89-2.54; P﹤0.00001 and C allele vs. T allele: OR, 0.70; 95% CI, 0.38-1.28; P﹤0.00001). No significant association was found between the -149C>T polymorphism in DNMT3B and CRC susceptibility.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The -149C>T polymorphism of DNMT3B is not associated with colorectal cancer risk: Evidence from a meta-analysis based on case-control studies

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