Evaluation of the effect of a chicken comb extract-containing supplement on cartilage and bone metabolism in athletes

Yoshimura,Masafumi; Aoba,Yukihiro; Watari,Taiji; Momomura,Rei; Watanabe,Keita; Tomonaga,Akihito; Matsunaga,Michitaka; Suda,Yoshimasa; Lee,Woo  Young; Asai,Katsuhito; Yoshimura,Kaori; Nakagawa,Takashi; Yamamoto,Tetsuro; Yamaguchi,Hideyo; Nagaoka,Isao

doi:10.3892/etm.2012.646

October 2012 Volume 4 Issue 4

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October 2012 Volume 4 Issue 4

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Article

Evaluation of the effect of a chicken comb extract-containing supplement on cartilage and bone metabolism in athletes

Authors:
- Masafumi Yoshimura
- Yukihiro Aoba
- Taiji Watari
- Rei Momomura
- Keita Watanabe
- Akihito Tomonaga
- Michitaka Matsunaga
- Yoshimasa Suda
- Woo Young Lee
- Katsuhito Asai
- Kaori Yoshimura
- Takashi Nakagawa
- Tetsuro Yamamoto
- Hideyo Yamaguchi
- Isao Nagaoka
View Affiliations / Copyright

Affiliations: Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan, Department of Medicine for Motor Organ, Graduate School of Medicine, Juntendo University, Tokyo, Japan, Kitashinyokohama Orthopedic Surgery,Kanagawa, Japan, Tana Orthopedic Surgery, Kanagawa, Japan, Kanagawa University, Kanagawa, Japan, Institute of Physical Education, Keio University, Kanagawa, Japan, Everlife Co., Ltd., Fukuoka, Japan, Total Technological Consultant Co., Ltd., Tokyo, Japan, Department of Host Defense and Biochemical Research, Graduate School of Medicine, Juntendo University, Tokyo, Japan
Pages: 577-580
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Published online on: July 24, 2012

https://doi.org/10.3892/etm.2012.646
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Abstract

In a previous study, we revealed that a commercially available product of dietary supplement containing a chicken comb extract (CCE), which is rich in hyaluronan, not only relieves joint pain and other symptoms, but also potentially improves the balance of type II collagen degradation/synthesis in patients with knee osteoarthritis. Since soccer is one of the sports most likely to cause knee osteoarthritis (OA), we evaluated the effect of a CCE-containing supplement on cartilage and bone metabolism in athletes. Fourteen and 15 subjects (all midfielders) were randomly assigned to receive the test product (test group) and the dummy placebo containing only vehicle (placebo group), respectively, for 12 weeks. The daily oral intake of the CCE-containing test product clearly decreased the urinary levels of both C-terminal crosslinked telopeptides of cartilage-specific type II collagen (CTX-II) as a type II collagen degradation marker and the N-terminal telopeptides of bone-specific type I collagen (NTx) as a marker of bone resorption at 12 weeks after the initiation of the intervention. By contrast, no significant reduction was detected in the placebo group at any timepoint during the intervention. These observations indicate that the test product is effective in inhibiting, not only cartilage degradation, but also bone remodeling. Thus, the CCE-containing supplement may be useful for the management of joint health in athletes.

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1	Roos H, Lindberg H, Gärdsell P, Lohmander LS and Wingstrand H: The prevalence of gonarthrosis and its relation to meniscectomy in former soccer players. Am J Sports Med. 22:219–222. 1994. View Article : Google Scholar : PubMed/NCBI
2	Kujala UM, Kettunen J, Paananen H, Aalto T, Battié MC, Impivaara O, Videman T and Sarna S: Knee osteoarthritis in former runners, soccer players, weight lifters, and shooters. Arthritis Rheum. 38:539–546. 1995. View Article : Google Scholar : PubMed/NCBI
3	Rannou F, Poiraudeau S and Revel M: Cartilage: from biomechanics to physical therapy. Ann Readapt Med Phys. 44:259–267. 2001.(In French).
4	Lequesne MG, Dang N and Lane NE: Sport practice and osteoarthritis of the limbs. Osteoarthritis Cartilage. 5:75–86. 1997. View Article : Google Scholar : PubMed/NCBI
5	Gelber AC, Hochberg MC, Mead LA, Wang NY, Wigley FM and Klag MJ: Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med. 133:321–328. 2000. View Article : Google Scholar : PubMed/NCBI
6	Poole AR, Ionescu M, Fitzcharles MA and Billinghurst RC: The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases. J Immunol Methods. 294:145–153. 2004. View Article : Google Scholar
7	Rousseau JC and Delmas PD: Biological markers in osteoarthritis. Nat Clin Pract Rheumatol. 3:346–356. 2007. View Article : Google Scholar
8	Bettica P, Cline G, Hart DJ, Meyer J and Spector TD: Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study. Arthritis Rheum. 46:3178–3184. 2002. View Article : Google Scholar : PubMed/NCBI
9	Yoshimura M, Sakamoto K, Tsuruta A, Yamamoto T, Ishida K, Yamaguchi H and Nagaoka I: Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. Int J Mol Med. 24:487–494. 2009.PubMed/NCBI
10	Hatayama T, Nagano M, Yamaguchi N, Kumagai S and Ohnuki K: The effect of a supplement on knee pain and discomfort evaluated by visual analog scale (VAS): a randomized, double-blind, placebo-controlled study. Kenko-shien. 10:13–17. 2008.(In Japanese).
11	Nagaoka I, Nabeshima K, Murakami S, Yamamoto T, Watanabe K, Tomonaga A and Yamaguchi H: Evaluation of the effects of a supplementary diet containing chicken comb extract on symptoms and cartilage metabolism in patients with knee osteoarthritis. Exp Ther Med. 1:817–827. 2010.PubMed/NCBI
12	Bangsbo J, Nørregaard L and Thorsø F: Activity profile of competition soccer. Can J Sport Sci. 16:110–116. 1991.PubMed/NCBI
13	Lohmander LS, Atley LM, Pietka TA and Eyre DR: The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum. 48:3130–3139. 2003. View Article : Google Scholar : PubMed/NCBI
14	Patti AM, Gabriele A, Vulcano A, Ramieri MT and Della Rocca C: Effect of hyaluronic acid on human chondrocytes cell lines from articular cartilage. Tissue Cell. 33:294–300. 2001. View Article : Google Scholar : PubMed/NCBI
15	Akmal M, Singh A, Anand A, Kesani A, Aslam N, Goodship A and Bentley G: The effects of hyaluronic acid on articular chondrocytes. J Bone Joint Surg Br. 87:1143–1149. 2005. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Evaluation of the effect of a chicken comb extract-containing supplement on cartilage and bone metabolism in athletes

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Abstract

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