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November 2012 Volume 4 Issue 5

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Article

Stress increases periodontal inflammation

  • Authors:
    • César Rivera
    • Francisco Monsalve
    • Iván Suazo
    • Javiera Becerra
  • View Affiliations / Copyright

    Affiliations: Unit of Histology and Embryology, Department of Basic Biomedical Sciences, Faculty of Health Sciences, University of Talca, Talca, Chile, Faculty of Medicine, Diego Portales University, Santiago, Chile, School of Dentistry, Faculty of Health Sciences, University of Talca, Talca, Chile
  • Pages: 883-888
    |
    Published online on: August 20, 2012
       https://doi.org/10.3892/etm.2012.675
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Abstract

This study aimed to examine the effect of chronic restraint stress (RS) on the severity of experimental periodontal disease in rats. A total of 32 male Sprague Dawley (SD) rats were divided into four groups: i) Rats receiving two treatment regimens, chronic stress induced by movement restriction in acrylic cylinders for 1-1.5 h daily and induction of experimental periodontal disease, using a nylon ligature which was placed around the first left mandibular molars (n=8); ii) induction of periodontal disease, without RS (n=8); iii) RS (n=8) and iv) control (n=8). After 15 days, blood samples were obtained, and blood glucose levels and the corticosterone concentration were measured as stress markers. The severity of periodontal disease was analyzed according to the level of gingival and bone inflammation, leading to compromise of the teeth involved. Chronic stress was induced with movement restriction (P≤0.05, Mann-Whitney U-test) and increased the severity (P≤0.05, Mann-Whitney U-test) of experimental perio­dontal disease in rats, according to the level of gingival and bone inflammation around the first left mandibular molars. The results of the present study showed that RS modulates periodontal inflammation and that the rat model described herein is suitable for investigating the association between stress and periodontal disease.
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1 

Gaspersic R, Stiblar-Martincic D and Skaleric U: Influence of restraint stress on ligature-induced periodontitis in rat. Eur J Oral Sci. 110:125–129. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Takada T, Yoshinari N, Sugiishi S, Kawase H, Yamane T and Noguchi T: Effect of restraint stress on the progression of experimental periodontitis in rats. J Periodontol. 75:306–315. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Peruzzo DC, Benatti BB, Antunes IB, Andersen ML, Sallum EA, Casati MZ, Nociti FH Jr and Nogueira-Filho GR: Chronic stress may modulate periodontal disease: a study in rats. J Periodontol. 79:697–704. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Oz H and Puleo D: Animal models for periodontal disease. J Biomed Biotechnol. 7548572011.PubMed/NCBI

5 

Genco RJ, Ho AW, Grossi SG, Dunford RG and Tedesco LA: Relationship of stress, distress, and inadequate coping behaviors to periodontal disease. J Periodontol. 70:711–723. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Hildebrand HC, Epstein J and Larjava H: The influence of psychological stress on periodontal disease. J West Soc Periodontol Periodontal Abstr. 48:69–77. 2000.PubMed/NCBI

7 

Green LW, Tryon WW, Marks B and Huryn J: Periodontal disease as a function of life events stress. J Hum Stress. 12:32–36. 1986. View Article : Google Scholar : PubMed/NCBI

8 

Freeman R and Gross S: Stress measures as predictors of periodontal disease-a preliminary communication. Community Dent Oral Epidemiol. 21:176–177. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Wimmer G, Janda M, Wieselmann-Penkner K, Jakse N, Polansky R and Pertl C: Coping with stress: its influence on periodontal disease. J Periodontol. 73:1343–1351. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Hilgert JB, Hugo FN, Bandeira DR and Bozzetti MC: Stress, cortisol, and periodontitis in a population aged 50 years and over. J Dent Res. 85:324–328. 2006.PubMed/NCBI

11 

Pistorius A, Krahwinkel T, Willershausen B and Boekstegen C: Relationship between stress factors and periodontal disease. Eur J Med Res. 7:393–398. 2002.PubMed/NCBI

12 

Breivik T, Thrane PS, Murison R and Gjermo P: Emotional stress effects on immunity, gingivitis and periodontitis. Eur J Oral Sci. 104:327–334. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Paré WP and Glavin GB: Restraint stress in biomedical research: a review. Neurosci Biobehav Rev. 10:339–370. 1986.

14 

Buynitsky T and Mostofsky D: Restraint stress in biobehavioral research: recent developments. Neurosci Biobehav Rev. 33:1089–1098. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Nakajima K, Hamada N, Takahashi Y, Sasaguri K, Tsukinoki K, Umemoto T and Sato S: Restraint stress enhances alveolar bone loss in an experimental rat model. J Periodontol Res. 41:527–534. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Semenoff Segundo A, Semenoff TA, Borges AH, Pedro FL and Sakai V: Methodological model of chronic stress associated with ligature-induced periodontitis in rats: a radiographic study. Braz Oral Res. 24:455–459. 2010.PubMed/NCBI

17 

Saini R, Saini S and Saini SR: Periodontitis and psychological stress: a dental view. Ind Psychiatry J. 19:66–67. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Grissom N and Bhatnagar S: Habituation to repeated stress: get used to it. Neurobiol Learn Mem. 92:215–224. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Rivera CA, Droguett DA, Kemmerling U and Venegas BA: Chronic restraint stress in oral squamous cell carcinoma. J Dent Res. 90:799–803. 2011. View Article : Google Scholar : PubMed/NCBI

20 

National Research Council, Institute for Laboratory Animal Resources: Guide for the Care and Use of Laboratory Animals. National Academy Press; Washington, DC: 1996

21 

Olsson IA and Dahlborn K: Improving housing conditions for laboratory mice: a review of ‘environmental enrichment’. Lab Anim. 36:243–270. 2002.

22 

Garcia MF: Estudio de la dinámica ósea mandibular y de los procesos reabsortivos de la cresta alveolar en ratas diabéticas y controles. Revista Académica Electrónica de la UNR 1: 1852-0707, 2008 (Available at: http://hdl.handle.net/2133/1509uri).

23 

Liu L, Li C, Cai C, Xiang J and Cao Z: Cyclophilin A (CypA) is associated with the inflammatory infiltration and alveolar bone destruction in an experimental periodontitis. Biochem Biophys Res Commun. 391:1000–1006. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Liu R, Bal HS, Desta T, Krothapalli N, Alyassi M, Luan Q and Graves DT: Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation. J Dent Res. 85:510–514. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Luan Q, Desta T, Chehab L, Sanders VJ, Plattner J and Graves DT: Inhibition of experimental periodontitis by a topical boron-based antimicrobial. J Dent Res. 87:148–152. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Graves DT, Naguib G, Lu H, Leone C, Hsue H and Krall E: Inflammation is more persistent in type 1 diabetic mice. J Dent Res. 84:324–328. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Lindhe J and Karring NT: Periodontología Clínica e Implantología Odontológica. 1. 5th edition. Editorial Medica Panamericana; Mexico: pp. 289–290. 2009

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Copy and paste a formatted citation
Spandidos Publications style
Rivera C, Monsalve F, Suazo I and Becerra J: Stress increases periodontal inflammation. Exp Ther Med 4: 883-888, 2012.
APA
Rivera, C., Monsalve, F., Suazo, I., & Becerra, J. (2012). Stress increases periodontal inflammation. Experimental and Therapeutic Medicine, 4, 883-888. https://doi.org/10.3892/etm.2012.675
MLA
Rivera, C., Monsalve, F., Suazo, I., Becerra, J."Stress increases periodontal inflammation". Experimental and Therapeutic Medicine 4.5 (2012): 883-888.
Chicago
Rivera, C., Monsalve, F., Suazo, I., Becerra, J."Stress increases periodontal inflammation". Experimental and Therapeutic Medicine 4, no. 5 (2012): 883-888. https://doi.org/10.3892/etm.2012.675
Copy and paste a formatted citation
x
Spandidos Publications style
Rivera C, Monsalve F, Suazo I and Becerra J: Stress increases periodontal inflammation. Exp Ther Med 4: 883-888, 2012.
APA
Rivera, C., Monsalve, F., Suazo, I., & Becerra, J. (2012). Stress increases periodontal inflammation. Experimental and Therapeutic Medicine, 4, 883-888. https://doi.org/10.3892/etm.2012.675
MLA
Rivera, C., Monsalve, F., Suazo, I., Becerra, J."Stress increases periodontal inflammation". Experimental and Therapeutic Medicine 4.5 (2012): 883-888.
Chicago
Rivera, C., Monsalve, F., Suazo, I., Becerra, J."Stress increases periodontal inflammation". Experimental and Therapeutic Medicine 4, no. 5 (2012): 883-888. https://doi.org/10.3892/etm.2012.675
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