Altered expression levels of IDH2 are involved in the development of colon cancer

  • Authors:
    • Qiang Lv
    • Shenyang Xing
    • Zhenxiao Li
    • Jianhua Li
    • Pengtao Gong
    • Xiaofang Xu
    • Le Chang
    • Xiaoxia Jin
    • Feng Gao
    • Wei Li
    • Guocai Zhang
    • Ju Yang
    • Xichen Zhang
  • View Affiliations

  • Published online on: August 20, 2012     https://doi.org/10.3892/etm.2012.676
  • Pages: 801-806
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Abstract

IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to α-ketoglutarate (α-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP+) to NADPH and participates in the citric acid cycle for energy production. Notably, this gene has been shown to be critical for cell proliferation. The abnormal expression of IDH2 has been reported in several types of cancer, and mutations in IDH2 have been identified in gliomas and acute myelogenous leukemia. The overexpression of IDH2 has been reported in endometrial, prostate and testicular cancer as well as in Kashin-Beck disease. In this study, we observed that IDH2 expression was significantly downregulated in early phase but was upregulated in advanced phase colon carcinoma compared to peritumoral tissues. In addition, we demonstrated that the growth of a colon carcinoma cell line was inhibited by IDH2-siRNA and increased following transfection with an IDH2-overexpressing plasmid. These results indicate that IDH2 may play a unique role in the development of colon carcinoma.
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November 2012
Volume 4 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Lv Q, Xing S, Li Z, Li J, Gong P, Xu X, Chang L, Jin X, Gao F, Li W, Li W, et al: Altered expression levels of IDH2 are involved in the development of colon cancer. Exp Ther Med 4: 801-806, 2012
APA
Lv, Q., Xing, S., Li, Z., Li, J., Gong, P., Xu, X. ... Zhang, X. (2012). Altered expression levels of IDH2 are involved in the development of colon cancer. Experimental and Therapeutic Medicine, 4, 801-806. https://doi.org/10.3892/etm.2012.676
MLA
Lv, Q., Xing, S., Li, Z., Li, J., Gong, P., Xu, X., Chang, L., Jin, X., Gao, F., Li, W., Zhang, G., Yang, J., Zhang, X."Altered expression levels of IDH2 are involved in the development of colon cancer". Experimental and Therapeutic Medicine 4.5 (2012): 801-806.
Chicago
Lv, Q., Xing, S., Li, Z., Li, J., Gong, P., Xu, X., Chang, L., Jin, X., Gao, F., Li, W., Zhang, G., Yang, J., Zhang, X."Altered expression levels of IDH2 are involved in the development of colon cancer". Experimental and Therapeutic Medicine 4, no. 5 (2012): 801-806. https://doi.org/10.3892/etm.2012.676