Effects of calcium and magnesium on acute and chronic neurotoxicity caused by oxaliplatin: A meta-analysis

  • Authors:
    • Rui Ao
    • Yu-Hui Wang
    • Rui-Wen Li
    • Zheng-Rong Wang
  • View Affiliations

  • Published online on: August 22, 2012     https://doi.org/10.3892/etm.2012.678
  • Pages: 933-937
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Abstract

The primary toxicity of oxaliplatin is neurotoxicity. Calcium and magnesium (Ca/Mg) are reported to be beneficial in protecting against this adverse effect. However, the results obtained from clinical trials are not definitive. The aim of this study was to evaluate whether Ca/Mg alleviates the neurotoxicity of oxaliplatin by performing a meta-analysis of the literature involving available randomized controlled trials. Systematic searches for trials were undertaken from the Cochrane Library, MEDLINE, CENTRAL, Embase, CBMdisc and CNKI databases without language limitations. The primary outcome was severe chronic neurotoxicity and the secondary outcome was acute neurotoxicity. Four randomized double-blind trials met the search criteria. The odds ratio (OR) comparing Ca/Mg treatment with placebo was 0.44 (0.23‑0.85, P=0.01) for severe chronic neurotoxicity of oxaliplatin (grade ≥2) and 0.41 (0.11-1.49, P=0.18) for acute neurotoxicity. In conclusion, Ca/Mg treatment does not reduce the incidence of acute neurotoxicity of oxaliplatin, but does reduce the incidence of severe chronic neurotoxicity (grade ≥2). No differences were observed in the outcomes of chemotherapy. Thus, Ca/Mg treatment is recommended for use as an adjunct with oxaliplatin.
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November 2012
Volume 4 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ao R, Wang Y, Li R and Wang Z: Effects of calcium and magnesium on acute and chronic neurotoxicity caused by oxaliplatin: A meta-analysis. Exp Ther Med 4: 933-937, 2012
APA
Ao, R., Wang, Y., Li, R., & Wang, Z. (2012). Effects of calcium and magnesium on acute and chronic neurotoxicity caused by oxaliplatin: A meta-analysis. Experimental and Therapeutic Medicine, 4, 933-937. https://doi.org/10.3892/etm.2012.678
MLA
Ao, R., Wang, Y., Li, R., Wang, Z."Effects of calcium and magnesium on acute and chronic neurotoxicity caused by oxaliplatin: A meta-analysis". Experimental and Therapeutic Medicine 4.5 (2012): 933-937.
Chicago
Ao, R., Wang, Y., Li, R., Wang, Z."Effects of calcium and magnesium on acute and chronic neurotoxicity caused by oxaliplatin: A meta-analysis". Experimental and Therapeutic Medicine 4, no. 5 (2012): 933-937. https://doi.org/10.3892/etm.2012.678