Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November 2012 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2012 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats

  • Authors:
    • Donghong Fang
    • Xuesi Wan
    • Wanping Deng
    • Hongyu Guan
    • Weijian Ke
    • Haipeng Xiao
    • Yanbing Li
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 871-876
    |
    Published online on: August 23, 2012
       https://doi.org/10.3892/etm.2012.680
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Fufang Xue Shuan Tong (FXST) capsules, a traditional Chinese medicine, have been used to treat diabetic nephropathy for many years. FXST has been shown to attenuate elevated levels of oxidative stress in the retina of diabetic rats. However, whether FXST protects kidneys through the same mechanism(s) remains unclear. In this study, diabetes was induced in rats by administration of a high‑fat diet and low-dose streptozotocin. Rats were administered low (450 mg/kg/day), middle (900 mg/kg/day) or high (1800 mg/kg/day) doses of FXST orally for 3 months. Another group was administered 50 mg/­kg/­day orally for the same period. The results indicated that all doses of FXST reduced urinary protein excretion and creatinine clearance and ameliorated the diabetic nephropathy-related mesangial matrix expansion. However, only middle and high doses of FXST prevented glomerular hypertrophy in diabetic rats, and the high dose showed the greatest inhibitory effect with regard to mesangial matrix expansion. Furthermore, superoxide dismutase activities were significantly elevated, whereas malondialdehyde levels were significantly reduced in the renal cortex following FXST treatment. The kidney-protective role of FXST is not inferior to that of captopril, one of the most commonly used drugs for the treatment of diabetic nephropathy. In conclusion, FXST retards the progression of diabetic nephropathy, while high-dose FXST shows the most prominent effect in counteracting the pathological changes of diabetic nephropathy. The renoprotective action of FXST is induced by the reduction of oxidative stress in diabetic nephropathy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

American Diabetes Assocation: Standards of medical care in diabetes – 2011. Diabetes Care. 34(Suppl 1): 11–61. 2011.

2 

Zhang J, Huang Q, Liu Y, et al: Effect of complex dribbing-pill of xue shuan tong on thrombus formation and microcirculation in rat. Zhong Yao Cai. 26:881–882. 2003.PubMed/NCBI

3 

Ye XF and Xu GZ: Effect of Fufang Xue Shuan Tong on retinal oxidative stress in diabetic rats. Chin J Oeul Fundus Dis. 26:176–178. 2010.

4 

Skrha J, Hodinar A, Kvasnicka J and Hilgertova J: Relationship of oxidative stress and fibrinolysis in diabetes mellitus. Diabet Med. 13:800–805. 1996. View Article : Google Scholar : PubMed/NCBI

5 

De Mattia G, Bravi MC, Laurenti O, et al: Reduction of oxidative stress by oral N-acetyl-L-cysteine treatment decreases plasma soluble vascular cell adhesion molecule-1 concentrations in non-obese, non-dyslipidaemic, normotensive, patients with non-insulin-dependent diabetes. Diabetologia. 41:1392–1396. 1998.

6 

Ihara Y, Toyokuni S, Uchida K, et al: Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. Diabetes. 48:927–932. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Pan HZ, Zhang L, Guo MY, et al: The oxidative stress status in diabetes mellitus and diabetic nephropathy. Acta Diabetol. 47:71–76. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Nam SM, Lee MY, Koh JH, et al: Effects of NADPH oxidase inhibitor on diabetic nephropathy in OLETF rats: the role of reducing oxidative stress in its protective property. Diabetes Res Clin Pract. 83:176–182. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Baynes JW: Role of oxidative stress in development of complications in diabetes. Diabetes. 40:405–412. 1991. View Article : Google Scholar : PubMed/NCBI

10 

Okada S, Shikata K, Matsuda M, et al: Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes. Diabetes. 52:2586–2593. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Ota T, Takamura T, Ando H, Nohara E, Yamashita H and Kobayashi K: Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model. Diabetologia. 46:843–851. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Ohkawa H, Ohishi N and Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:351–358. 1979. View Article : Google Scholar : PubMed/NCBI

13 

Paoletti F, Mocali A and Aldinucci D: Superoxide-driven NAD(P)H oxidation induced by EDTA-manganese complex and mercaptoethanol. Chem Biol Interact. 76:3–18. 1990. View Article : Google Scholar : PubMed/NCBI

14 

Agardh CD, Stenram U, Torffvit O and Agardh E: Effects of inhibition of glycation and oxidative stress on the development of diabetic nephropathy in rats. J Diabetes Complications. 16:395–400. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Chen ZY, Yan MX, Cai DL, He BH, Chen H and Liu QS: Effect of SanQi on alcoholic fatty liver disease. Chin J Trad Chin Med Pharm. 21:614–616. 2006.

16 

Sun W, Feng LY, Zhao ZJ, Liu TH and Yang MJ: Study on antioxidant effects and inhibition of podocyte apoptosis of PNS on DN rat. Chin J Trad Chin Med Pharm. 26:1062–1067. 2011.

17 

Chen JX, Li AY, Wang ZY and Liu HX: Impact of Danshen powder injection on oxidative stress after the intervention in the patients with acute coronary syndromes of blood stasis type. World J Integr Trad West Med. 6:122–124. 2011.

18 

Liu C, Min LQ, Ji ZS, Wang Q, Jia YJ and Li SY: Protective effects of salvia miltiorrhizae on oxidative stress in rats with focal cerebral ischemia. Chin J Clin Rehabil. 10:37–39. 2006.

19 

Mo ZY, Liang D, Shitu Y, Huang PP and Chen XW: Effect of astragalus on oxidative stress status in primary nephrotic syndrome. Chin J Integr Trad Western Nephrol. 5:209–211. 2004.

20 

Guan FY, Li H, Yu XX and Yang XJ: Effects of astragalus injection on myocardial cell damages due to oxidative stress. Chin J Rehabil Theory Pract. 16:830–832. 2010.

21 

Liu ZJ, Li L, Wang J, Yan J and Liu CM: Antioxidant activities of polyphenol from Scrophularia ningpoensis Hemsl. Lishizhen Med Materia Medica Res. 21:796–798. 2010.

22 

Shah IM, Mackay SP and McKay GA: Therapeutic strategies in the treatment of diabetic nephropathy – a translational medicine approach. Curr Med Chem. 16:997–1016. 2009.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fang D, Wan X, Deng W, Guan H, Ke W, Xiao H and Li Y: Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats. Exp Ther Med 4: 871-876, 2012.
APA
Fang, D., Wan, X., Deng, W., Guan, H., Ke, W., Xiao, H., & Li, Y. (2012). Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats. Experimental and Therapeutic Medicine, 4, 871-876. https://doi.org/10.3892/etm.2012.680
MLA
Fang, D., Wan, X., Deng, W., Guan, H., Ke, W., Xiao, H., Li, Y."Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats". Experimental and Therapeutic Medicine 4.5 (2012): 871-876.
Chicago
Fang, D., Wan, X., Deng, W., Guan, H., Ke, W., Xiao, H., Li, Y."Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats". Experimental and Therapeutic Medicine 4, no. 5 (2012): 871-876. https://doi.org/10.3892/etm.2012.680
Copy and paste a formatted citation
x
Spandidos Publications style
Fang D, Wan X, Deng W, Guan H, Ke W, Xiao H and Li Y: Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats. Exp Ther Med 4: 871-876, 2012.
APA
Fang, D., Wan, X., Deng, W., Guan, H., Ke, W., Xiao, H., & Li, Y. (2012). Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats. Experimental and Therapeutic Medicine, 4, 871-876. https://doi.org/10.3892/etm.2012.680
MLA
Fang, D., Wan, X., Deng, W., Guan, H., Ke, W., Xiao, H., Li, Y."Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats". Experimental and Therapeutic Medicine 4.5 (2012): 871-876.
Chicago
Fang, D., Wan, X., Deng, W., Guan, H., Ke, W., Xiao, H., Li, Y."Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats". Experimental and Therapeutic Medicine 4, no. 5 (2012): 871-876. https://doi.org/10.3892/etm.2012.680
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team