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Article

Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture

  • Authors:
    • Ke Yin
    • Qiande Liao
    • Da Zhong
    • Jie Ding
    • Bing Niu
    • Qiupping Long
    • Dengfeng Ding
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 889-894
    |
    Published online on: August 28, 2012
       https://doi.org/10.3892/etm.2012.685
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Abstract

The goal of this study was to determine outcomes related to limb salvage vs. amputation for treating high-grade and localized osteosarcoma in patients with pathological fractures. Literature search was conducted using Medline, Embase and the Cochrane Database. Two reviewers independently assessed all eligible publications. The primary outcome measurement was pooled odds ratio (OR) and 95% confidence interval (CI) for the risk of local recurrence, 5-year overall survival rate and metastatic occurrence calculated through the fixed-effects method. Seven eligible studies were identified, which included a total of 284 patients. The risk for local recurrence and 5-year overall survival rate did not differ significantly (P>0.05) between the limb salvage group and amputation group, with an OR of 1.48 (95% CI, 0.67-3.30) and 1.85 (95% CI, 0.86-3.98), respectively. The risk for metastatic occurrence differed significantly (P<0.05), with an OR of 0.30 (95% CI, 0.10-0.91). The occurrence of a pathological fracture is not regarded as an absolute contraindication to limb salvage in patients with high-grade and localized osteosarcoma. Limb salvage as an alternative for treating high-grade and localized osteosarcoma in patients with pathological fracture does not greatly increase the risk for local recurrence or 5-year overall survival rate compared to amputation and has a lower risk for metastatic occurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Yin K, Liao Q, Zhong D, Ding J, Niu B, Long Q and Ding D: Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. Exp Ther Med 4: 889-894, 2012.
APA
Yin, K., Liao, Q., Zhong, D., Ding, J., Niu, B., Long, Q., & Ding, D. (2012). Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. Experimental and Therapeutic Medicine, 4, 889-894. https://doi.org/10.3892/etm.2012.685
MLA
Yin, K., Liao, Q., Zhong, D., Ding, J., Niu, B., Long, Q., Ding, D."Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture". Experimental and Therapeutic Medicine 4.5 (2012): 889-894.
Chicago
Yin, K., Liao, Q., Zhong, D., Ding, J., Niu, B., Long, Q., Ding, D."Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture". Experimental and Therapeutic Medicine 4, no. 5 (2012): 889-894. https://doi.org/10.3892/etm.2012.685
Copy and paste a formatted citation
x
Spandidos Publications style
Yin K, Liao Q, Zhong D, Ding J, Niu B, Long Q and Ding D: Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. Exp Ther Med 4: 889-894, 2012.
APA
Yin, K., Liao, Q., Zhong, D., Ding, J., Niu, B., Long, Q., & Ding, D. (2012). Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. Experimental and Therapeutic Medicine, 4, 889-894. https://doi.org/10.3892/etm.2012.685
MLA
Yin, K., Liao, Q., Zhong, D., Ding, J., Niu, B., Long, Q., Ding, D."Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture". Experimental and Therapeutic Medicine 4.5 (2012): 889-894.
Chicago
Yin, K., Liao, Q., Zhong, D., Ding, J., Niu, B., Long, Q., Ding, D."Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture". Experimental and Therapeutic Medicine 4, no. 5 (2012): 889-894. https://doi.org/10.3892/etm.2012.685
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