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Article

Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies

  • Authors:
    • Wei-Dong Leng
    • Xian-Tao Zeng
    • Yong-Ji Chen
    • Xiao-Li Duan
    • Yu-Ming Niu
    • Rong-Pei Long
    • Zhi-Xiao Luo
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial-Head and Neck Surgery, Centre of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Digestion, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Foreign Languages, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
  • Pages: 938-948
    |
    Published online on: August 28, 2012
       https://doi.org/10.3892/etm.2012.687
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Abstract

The aim of this study was to explore the cytochrome P450 2E1 (CYP2E1) RsaI/PstI polymorphism and risk of esophageal cancer (EC) in mainland Chinese populations. A systematic search of PubMed, EMBASE, Web of Science, CBM, CNKI and VIP databases for publications on the CYP2E1 RsaI/PstI polymorphism and risk of EC was performed. and the genotype data were analyzed in a meta‑analysis. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were estimated to assess the association. Sensitivity analysis, test of heterogeneity and assessment of publication bias were performed. The search yielded 17 studies including 18 trails involving 1,663 cases and 2,603 controls. The meta-analyses showed a significant association between the CYP2E1 RsaI/PstI polymorphism and risk of EC in the mainland Chinese population (c2 vs. c1: OR=0.64; 95% CI, 0.50-0.81; P<0.001; c2/c2 vs. c1/c1: OR=0.73; 95% CI, 0.57‑0.93; c2/c2 vs. c1/c1+c1/c2: OR=0.76; 95% CI, 0.60-0.96; P=0.02; c1/c2 vs. c1/c1: OR=0.54; 95% CI, 0.38-0.75; P<0.001; c1/c2+c2/c2 vs. c1/c1: OR=0.48; 95% CI, 0.34-0.70; P<0.001). An increased cancer risk in all genetic models was identified following stratification by ethnicity, source of controls and tumor type. In conclusion, in all genetic models, the association between the CYP2E1 RsaI/PstI polymorphism and risk of EC in the mainland Chinese population was significant. This meta‑analysis suggests that the CYP2E1 RsaI/PstI polymorphism is a risk factor for EC, and the c2 allele is a factor that lowers the possibility of EC in the mainland Chinese population and this association did not change due to ethnic differences in genetic backgrounds and the environment.
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Copy and paste a formatted citation
Spandidos Publications style
Leng W, Zeng X, Chen Y, Duan X, Niu Y, Long R and Luo Z: Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies. Exp Ther Med 4: 938-948, 2012.
APA
Leng, W., Zeng, X., Chen, Y., Duan, X., Niu, Y., Long, R., & Luo, Z. (2012). Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies. Experimental and Therapeutic Medicine, 4, 938-948. https://doi.org/10.3892/etm.2012.687
MLA
Leng, W., Zeng, X., Chen, Y., Duan, X., Niu, Y., Long, R., Luo, Z."Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies". Experimental and Therapeutic Medicine 4.5 (2012): 938-948.
Chicago
Leng, W., Zeng, X., Chen, Y., Duan, X., Niu, Y., Long, R., Luo, Z."Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies". Experimental and Therapeutic Medicine 4, no. 5 (2012): 938-948. https://doi.org/10.3892/etm.2012.687
Copy and paste a formatted citation
x
Spandidos Publications style
Leng W, Zeng X, Chen Y, Duan X, Niu Y, Long R and Luo Z: Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies. Exp Ther Med 4: 938-948, 2012.
APA
Leng, W., Zeng, X., Chen, Y., Duan, X., Niu, Y., Long, R., & Luo, Z. (2012). Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies. Experimental and Therapeutic Medicine, 4, 938-948. https://doi.org/10.3892/etm.2012.687
MLA
Leng, W., Zeng, X., Chen, Y., Duan, X., Niu, Y., Long, R., Luo, Z."Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies". Experimental and Therapeutic Medicine 4.5 (2012): 938-948.
Chicago
Leng, W., Zeng, X., Chen, Y., Duan, X., Niu, Y., Long, R., Luo, Z."Cytochrome P450 2E1 RsaI/PstI polymorphism and risk of esophageal cancer: A meta-analysis of 17 case-control studies". Experimental and Therapeutic Medicine 4, no. 5 (2012): 938-948. https://doi.org/10.3892/etm.2012.687
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