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Article

Methylation of tumor suppressor genes in ovarian cancer

  • Authors:
    • Filiz Ozdemir
    • Julide Altinisik
    • Ates Karateke
    • Hakan Coksuer
    • Nur Buyru
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey, Department of Gynecology and Obstetrics, Zeynep Kamil Maternity and Child Research and Training Hospital, Istanbul, Turkey
  • Pages: 1092-1096
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    Published online on: September 18, 2012
       https://doi.org/10.3892/etm.2012.715
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Abstract

Aberrant methylation of gene promoter regions is one of the mechanisms for inactivation of tumor suppressor genes in human malignancies. In this study, the methylation pattern of 24 tumor suppressor genes was analyzed in 75 samples of ovarian cancer using the methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay. Of the 24 tumor suppressor genes examined, aberrant methylation was observed in 17. The three most frequently methylated genes were CDKN2B, CDH13 and RASSF1, followed by ESR1 and MLH1. Methylation frequencies ranged from 1.3% for CDKN2A, RARβ, CASP8, VHL and TP73 to 24% for CDKN2B. The corresponding normal DNA from each patient was also investigated. Methylation was detected in tumors, although not in normal tissues, with the exception of two samples, indicating aberrant methylation in tumors. Clear cell carcinoma samples exhibited a higher frequency of CDKN2B promoter hypermethylation compared to those of other histological types (P=0.05). Our data indicate that methylation of the CDKN2B gene is a frequent event in ovarian carcinogenesis and that analysis of only three genes is sufficient to detect the presence of methylation in 35% of ovarian cancer cases. However, more studies using a much larger sample size are needed to define the potential role of DNA methylation as a marker for ovarian cancer.
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View References

1 

Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics. CA Cancer J Clin. 57:43–66. 2007.

2 

Clark TG, Stewart ME, Altman DG, Gabra H and Smyth JF: A prognostic model for ovarian cancer. Br J Cancer. 85:944–952. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Baylin SB and Herman JG: DNA methylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 16:168–174. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Jones PA: DNA methylation errors and cancer. Cancer Res. 56:2463–2467. 1996.PubMed/NCBI

5 

Jones PA and Laird PW: Cancer epigenetics comes of age. Nat Genet. 21:163–167. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Wilson AS, Power BE and Molloy PL: DNA hypomethylation and human diseases. Biochem Biophys Acta. 1775:138–162. 2007.PubMed/NCBI

7 

Jones PA: The DNA methylation paradox. Trends Genet. 15:34–37. 1999. View Article : Google Scholar

8 

Lund AH and van Lohuizen M: Epigenetics and cancer. Genes Dev. 18:2315–2335. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Laird PW: Cancer epigenetics. Hum Mol Genet. 14:R65–R76. 2005. View Article : Google Scholar

10 

Ducasse M and Brown MA: Epigenetic aberrations and cancer. Mol Cancer. 5:602006. View Article : Google Scholar

11 

Paluszczak J and Baer-Dubowska W: Epigenetic diagnostics of cancer - the application of DNA methylation markers. J Appl Genet. 47:365–375. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Barton CA, Hacker NF, Clark SJ and O’Brien PM: DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment. Gynecol Oncol. 109:129–139. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Swisher EM, Gonzalez RM, Taniguchi T, Garcia RL, Walsh T, Goff BA and Welcsh P: Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas. Mol Cancer. 8:482009. View Article : Google Scholar : PubMed/NCBI

14 

Ibanez de Caceres I, Battagli C, Esteller M, Herman JG, Dulaimi E, Edelson MI, Bergman C, Ehya H, Eisenberg BL and Cairns P: Tumor cell-specific BRCA1 and RASSF1A hyper-methylation in serum, plasma and peritoneal fluid from ovarian cancer patients. Cancer Res. 64:6476–6481. 2004.PubMed/NCBI

15 

Makarla PB, Saboorian MH, Ashfaq R, Toyooka KO, Toyooka S, Minna JD, Gazdar AF and Schorge JO: Promoter hypermethylation profile of ovarian epithelial neoplasms. Clin Cancer Res. 11:5365–5369. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Rathi A, Virmani AK, Schorge JO, Elias KJ, Maruyama R, Minna JD, Mok SC, Girard L, Fishman DA and Gazdar AF: Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women. Clin Cancer Res. 8:3324–3331. 2002.PubMed/NCBI

17 

Yuecheng Y, Hongmei L and Xiaoyan X: Clinical evaluation of E-cadherin expression and its regulation mechanism in epithelial ovarian cancer. Clin Exp Metastasis. 23:65–74. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Tam KF, Liu VW, Liu SS, Tsang PC, Cheung AN, Yip AM and Ngan HY: Methylation profile in benign, borderline and malignant ovarian tumors. J Cancer Res Clin Oncol. 133:331–341. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Strathdee G, Appleton K, Illand M, Millan DW, Sargent J, Paul J and Brown R: Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes. Am J Pathol. 158:1121–1127. 2001. View Article : Google Scholar

20 

Kiwerska K, Rydzanicz M, Kram A, Pastok M, Antkowiak A, Domagala W and Szyfter K: Mutational analysis of CDKN2A gene in a group of 390 larynx cancer patients. Mol Biol Rep. 37:325–332. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Costello JF, Frühwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltomäki P, Lang JC, Schuller DE, Yu L, Bloomfield CD, Caligiuri MA, Yates A, Nishikawa R, Su Huang H, Petrelli NJ, Zhang X, O’Dorisio MS, Held WA, Cavenee WK and Plass C: Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet. 24:132–138. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Mehrotra J, Ganpat MM, Kanan Y, Fackler MJ, McVeigh M, Lahti-Domenici J, Polyak K, Argani P, Naab T, Garrett E, Parmigiani G, Broome C and Sukumar S: Estrogen receptor/progesterone receptor-negative breast cancers of young African-American women have a higher frequency of methylation of multiple genes than those of Caucasian women. Clin Cancer Res. 10:2052–2057. 2004. View Article : Google Scholar

23 

Nygren AO, Ameziane N, Duarte HM, Vijzelaar RN, Waisfisz Q, Hess CJ, Schouten JP and Errami A: Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res. 33:e1282005. View Article : Google Scholar : PubMed/NCBI

24 

Warnecke PM and Bestor TH: Cytosine methylation and human cancer. Curr Opin Oncol. 12:68–73. 2000. View Article : Google Scholar : PubMed/NCBI

25 

El-Osta A, Baker EK and Wolffe AP: Profiling methyl-CpG specific determinants on transcriptionally silent chromatin. Mol Biol Rep. 28:209–215. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Jones PA and Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet. 3:415–428. 2002.PubMed/NCBI

27 

Esteller M, Corn PG, Baylin SB and Herman JG: A gene hyper-methylation profile of human cancer. Cancer Res. 61:3225–3229. 2001.PubMed/NCBI

28 

Sellar GC, Watt KP, Rabiasz GJ, Stronach EA, Li L, Miller EP, Massie CE, Miller J, Contreras-Moreira B, Scott D, Brown I, Williams AR, Bates PA, Smyth JF and Garba H: OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Nat Genet. 34:337–343. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Teodoridis JM, Hall J, Marsh S, Kannall HD, Smyth C, Curto J, Siddiqui N, Gabra H, McLeod HL, Strathdee G and Brown R: CpG island methylation of DNA damage response genes in advanced ovarian cancer. Cancer Res. 65:8961–8967. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Wakana K, Akiyama Y, Aso T and Yuasa Y: Involvement of GATA-4/5 transcription factors in ovarian carcinogenesis. Cancer Lett. 241:281–288. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Milde-Langosch K, Ocon E, Becker G and Löning T: p16/MTS1 inactivation in ovarian carcinomas: high frequency of reduced protein expression associated with hyper-methylation or mutation in endometrioid and mucinous tumors. Int J Cancer. 79:61–65. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Kudoh K, Ichikawa Y, Yoshida S, Hirai M, Kikuchi Y, Nagata I, Miwa M and Uchida K: Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer. Int J Cancer. 99:579–582. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Schildkraut JM, Moorman PG, Bland AE, Halabi S, Calingaert B, Whitaker R, Lee PS, Elkins-Williams T, Bentley RC, Marks JR and Berchuck A: Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup. Cancer Epidemiol Biomarkers Prev. 17:585–593. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Lee YH, Heo JH, Kim TH, Kang H, Kim G, Kim J, Cho SH and An HJ: Significance of cell cycle regulatory proteins as malignant and prognostic biomarkers in ovarian epithelial tumors. Int J Gynecol Pathol. 30:205–217. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Drexler HG: Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia. 12:845–859. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Yang HJ, Liu VW, Wang Y, Tsang PC and Ngan HY: Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. BMC Cancer. 6:2122006. View Article : Google Scholar : PubMed/NCBI

37 

Fujita M, Enomoto T, Haba T, Nakashima R, Sasaki M, Yoshino K, Wada H, Buzard GS, Matsuzaki N, Wakasa K and Murata Y: Alteration of p16 and p15 genes in common epithelial ovarian tumors. Int J Cancer. 74:148–155. 1997. View Article : Google Scholar : PubMed/NCBI

38 

Dodge JE, Munson C and List AF: KG-1 and KG-1a model the p15 CpG island methylation observed in acute myeloid leukemia patients. Leukemia Res. 25:917–925. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Aggerholm A, Guldberg P, Hokland M and Hokland P: Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia. Cancer Res. 59:436–441. 1999.PubMed/NCBI

40 

Herman JG, Jen J, Merlo A and Baylin SB: Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res. 56:722–727. 1996.PubMed/NCBI

41 

Wang Y, Zhang D, Zheng W, Luo J, Bai Y and Lu Z: Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray. Cancer. 112:1325–1336. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Buyru N, Altinisik J, Ozdemir F, Demokan S and Dalay N: Methylation profiles in breast cancer. Cancer Invest. 27:307–312. 2009. View Article : Google Scholar

43 

Liu Z, Wang LE, Wang L, Lu KH, Mills GB, Bondy ML and Wei Q: Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer. Clin Cancer Res. 11:4968–4976. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Kawakami M, Staub J, Cliby W, Hartmann L, Smith DI and Shridhar V: Involvement of H-cadherin (CDH13) on 16q in the region of frequent deletion in ovarian cancer. Int J Oncol. 15:715–720. 1999.PubMed/NCBI

45 

Toyooka KO, Toyooka S, Virmani AK, Sathyanarayana UG, Euhus DM, Gilcrease M, Minna JD and Gazdar AF: Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas. Cancer Res. 61:4556–4560. 2001.PubMed/NCBI

46 

Wu Q, Lothe RA, Ahlquist T, Silins I, Tropé CG, Micci F, Nesland JM, Suo Z and Lind GE: DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. Mol Cancer. 6:452007. View Article : Google Scholar : PubMed/NCBI

47 

Dammann R, Schagdarsurengin U, Seidal C, Strunnikova M, Rastetter M, Baier K and Pfeifer GP: The tumor suppressor RASSF1A in human carcinogenesis: an update. Histol Histopathol. 20:645–663. 2005.PubMed/NCBI

48 

Yoon JH, Dammann R and Pfeifer GP: Hypermethylation of the CpG island of RASSF1A gene in ovarian and renal cell carcinomas. Int J Cancer. 94:212–217. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Agathanggelou A, Honorio S, Macartney DP, Martinez A, Dallol A, Rader J, Fullwood P, Chauhan A, Walker R, Shaw JA, Hosoe S, Lerman MI, Minna JD, Maher ER and Latif F: Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumors. Oncogene. 20:1509–1518. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ozdemir F, Altinisik J, Karateke A, Coksuer H and Buyru N: Methylation of tumor suppressor genes in ovarian cancer. Exp Ther Med 4: 1092-1096, 2012.
APA
Ozdemir, F., Altinisik, J., Karateke, A., Coksuer, H., & Buyru, N. (2012). Methylation of tumor suppressor genes in ovarian cancer. Experimental and Therapeutic Medicine, 4, 1092-1096. https://doi.org/10.3892/etm.2012.715
MLA
Ozdemir, F., Altinisik, J., Karateke, A., Coksuer, H., Buyru, N."Methylation of tumor suppressor genes in ovarian cancer". Experimental and Therapeutic Medicine 4.6 (2012): 1092-1096.
Chicago
Ozdemir, F., Altinisik, J., Karateke, A., Coksuer, H., Buyru, N."Methylation of tumor suppressor genes in ovarian cancer". Experimental and Therapeutic Medicine 4, no. 6 (2012): 1092-1096. https://doi.org/10.3892/etm.2012.715
Copy and paste a formatted citation
x
Spandidos Publications style
Ozdemir F, Altinisik J, Karateke A, Coksuer H and Buyru N: Methylation of tumor suppressor genes in ovarian cancer. Exp Ther Med 4: 1092-1096, 2012.
APA
Ozdemir, F., Altinisik, J., Karateke, A., Coksuer, H., & Buyru, N. (2012). Methylation of tumor suppressor genes in ovarian cancer. Experimental and Therapeutic Medicine, 4, 1092-1096. https://doi.org/10.3892/etm.2012.715
MLA
Ozdemir, F., Altinisik, J., Karateke, A., Coksuer, H., Buyru, N."Methylation of tumor suppressor genes in ovarian cancer". Experimental and Therapeutic Medicine 4.6 (2012): 1092-1096.
Chicago
Ozdemir, F., Altinisik, J., Karateke, A., Coksuer, H., Buyru, N."Methylation of tumor suppressor genes in ovarian cancer". Experimental and Therapeutic Medicine 4, no. 6 (2012): 1092-1096. https://doi.org/10.3892/etm.2012.715
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