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Article

Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals

  • Authors:
    • Si-Ping Wang
    • Yan-Hong Chen
    • Hong Li
  • View Affiliations / Copyright

    Affiliations: Department of Special Service of the Chinese PLA General Hospital, Beijing 100853, P.R. China
  • Pages: 1107-1111
    |
    Published online on: September 26, 2012
       https://doi.org/10.3892/etm.2012.724
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Abstract

The levels of polyunsaturated fatty acids (PUFAs) in blood is closely associated with the status of the health of individuals; in particular, the lack of ω-3 fatty acids may lead to the development of numerous diseases. The aim of this study was to investigate the levels of PUFAs, and their correlation with triglycerides and other factors in blood. The levels of PUFAs and blood lipids were detected in 156 healthy individuals; the blood samples were tested by combined thin-layer and gas liquid chromatographic analysis. The level of ω-3 fatty acids was low in the subjects and the ω-3 index was 4.25%, while the ω-6:ω-3 ratio was at a satisfactory level. There was a strong inverse correlation between ω-3 fatty acids and triglycerides, and a strong positive correlation between ω-3 fatty acids and high density lipoprotein (HDL). Eicosapentaenoic acid and docosahexaenoic acid were inversely correlated with triglycerides, and positively correlated with HDL. In conclusion, ω-3 fatty acids are able to adjust the levels of blood lipids, and lower the levels of triglycerides, which may contribute to human health.
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1 

Willett WC: Dietary fats and coronary heart disease. J Intern Med. 272:13–24. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Deckelbaum RJ and Torrejon C: The omega-3 fatty acid nutritional landscape: health benefits and sources. J Nutr. 142:587S–591S. 2012.PubMed/NCBI

3 

Hayakawa S, Yoshikawa D, Ishii H, Tanaka M, Kumagai S, Matsumoto M, et al: Association of plasma omega-3 to omega-6 polyunsaturated fatty acid ratio with complexity of coronary artery lesion. Intern Med. 51:1009–1014. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Mirmiran P, Hosseinpour-Niazi S, Naderi Z, Bahadoran Z, Sadeghi M and Azizi F: Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. Nutrition. 28:856–863. 2012.

5 

De Lorgeril M and Salen P: New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids. BMC Med. 21:105–110. 2012.PubMed/NCBI

6 

Harris WS: Fatty acid profile, RBC, what is included and its significance in cardiac health. Curr Cardiol Rep. 12:503–508. 2010.

7 

Kris-Etherton PM, Harris WS and Appel LJ; American Heart Association: Nutrition Committee: Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 106:2747–2757. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Harris WS, Kris-Etherton PM and Harris KA: Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults. Curr Atheroscler Rep. 10:503–509. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Mozaffarian D, Lemaitre RN, King IB, et al: Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study. Ann Intern Med. 155:160–170. 2011.

10 

Delgado-Lista J, Perez-Martinez P, Lopez-Miranda J and Perez-Jimenez F: Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. Br J Nutr. 2:S201–213. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Wu JH, Lemaitre RN, King IB, et al: Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. Circulation. 125:1084–1093. 2012.

12 

Lavie CJ, Milani RV, Mehra MR and Ventura HO: Omega-3 polyunsaturated fatty acids and cardiovascular diseases. J Am Coll Cardiol. 54:585–594. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Rodacki CL, Rodacki AL, Pereira G, et al: Fish-oil supplementation enhances the effects of strength training in elderly women. Am J Clin Nutr. 95:428–436. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Kawabata T, Hirota S, Hirayama T, et al: Associations between dietary n-6 and n-3 fatty acids and arachidonic acid compositions in plasma and erythrocytes in young and elderly Japanese volunteers. Lipids in Health and Disease. 10:1382011. View Article : Google Scholar : PubMed/NCBI

15 

Aarsetoey H, Aarsetoey R, Lindner T, Staines H, Harris WS and Nilsen DW: Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. Lipids. 46:151–161. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Motoyama KR, Curb JD, Kadowaki T, et al: Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men. Am J Clin Nutr. 90:49–55. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Rondeau I, Picard S, Bah TM, Roy L, Godbout R and Rousseau G: Effects of different dietary omega-6/3 polyunsaturated fatty acids ratios on infarct size and the limbic system after myocardial infarction. Can J Physiol Pharmacol. 89:169–176. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Bernstein AM, Ding EL, Willett WC and Rimm EB: A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. J Nutr. 142:99–104. 2012. View Article : Google Scholar

19 

Popa I, Pin D, Remoué N, et al: Analysis of epidermal lipids in normal and atopic dogs, before and after administration of an oral omega-6/omega-3 fatty acid feed supplement. A pilot study. Vet Res Commun. 35:1–9. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Crowe FL, Skeaff CM, Green TJ and Gray AR: Serum n-3 long-chain PUFA differ by sex and age in a population-based survey of New Zealand adolescents and adults. Br J Nutr. 99:168–174. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Hauner H, Much D, Vollhardt C, et al: Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial. Am J Clin Nutr. 95:383–394. 2012.

22 

Deckelbaum RJ: n-6 and n-3 Fatty acids and atherosclerosis: ratios or amounts? Arterioscler Thromb Vasc Biol. 30:2325–2326. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Sioen I, Huybrechts I, Verbeke W, Camp JV and De Henauw S: n-6 and n-3 PUFA intakes of pre-school children in Flanders, Belgium. Br J Nutr. 98:819–825. 2007. View Article : Google Scholar : PubMed/NCBI

24 

O’Sullivan TA, Ambrosini G, Beilin LJ, Mori TA and Oddy WH: Dietary intake and food sources of fatty acids in Australian adolescents. Nutrition. 27:153–159. 2011.

25 

Vedtofte MS, Jakobsen MU, Lauritzen L and Heitmann BL: Dietary a-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. Am J Clin Nutr. 94:1097–1103. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Simopoulos AP: The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood). 233:674–688. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Dietary supplementation with n-3 polyunsaturated fatty acids and results of the GISSI-Prevenzione trial. Lancet. 354:447–455. 1999. View Article : Google Scholar : PubMed/NCBI

28 

de Lorgeril M, Renaud S, Mamelle N, et al: Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 343:1454–1459. 1994.

29 

Bartram HP, Gostner A, Reddy BS, et al: Missing anti-proliferative effect of fish oil on rectal epithelium in healthy volunteers consuming a high-fat diet: potential role of the n-3:n-6 fatty acid ratio. Eur J Cancer Prev. 4:231–237. 1995. View Article : Google Scholar : PubMed/NCBI

30 

James MJ and Cleland LG: Dietary n-3 fatty acids and therapy for rheumatoid arthritis. Semin Arthritis Rheum. 27:85–97. 1997. View Article : Google Scholar : PubMed/NCBI

31 

Broughton KS, Johnson CS, Pace BK, Liebman M and Kleppinger KM: Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production. Am J Clin Nutr. 65:1011–1017. 1997.PubMed/NCBI

32 

Swanson D, Block R and Mousa SA: Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv Nutr. 3:1–7. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Marinangeli CP and Jones PJ: Plant sterols, marine-derived omega-3 fatty acids and other functional ingredients: a new frontier for treating hyperlipidemia. Nutr Metab (Lond). 7:762010. View Article : Google Scholar

34 

Dayspring TD: Understanding hypertriglyceridemiain women: clinical impact and management with prescription omega-3-acid ethyl esters. Int J Womens Health. 3:87–97. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Holub BJ, Wlodek M, Rowe W and Piekarski J: Correlation of omega-3 levels in serum phospholipid from 2053 human blood samples with key fatty acid ratios. Nutr J. 8:582009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang S, Chen Y and Li H: Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals. Exp Ther Med 4: 1107-1111, 2012.
APA
Wang, S., Chen, Y., & Li, H. (2012). Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals. Experimental and Therapeutic Medicine, 4, 1107-1111. https://doi.org/10.3892/etm.2012.724
MLA
Wang, S., Chen, Y., Li, H."Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals". Experimental and Therapeutic Medicine 4.6 (2012): 1107-1111.
Chicago
Wang, S., Chen, Y., Li, H."Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals". Experimental and Therapeutic Medicine 4, no. 6 (2012): 1107-1111. https://doi.org/10.3892/etm.2012.724
Copy and paste a formatted citation
x
Spandidos Publications style
Wang S, Chen Y and Li H: Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals. Exp Ther Med 4: 1107-1111, 2012.
APA
Wang, S., Chen, Y., & Li, H. (2012). Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals. Experimental and Therapeutic Medicine, 4, 1107-1111. https://doi.org/10.3892/etm.2012.724
MLA
Wang, S., Chen, Y., Li, H."Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals". Experimental and Therapeutic Medicine 4.6 (2012): 1107-1111.
Chicago
Wang, S., Chen, Y., Li, H."Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals". Experimental and Therapeutic Medicine 4, no. 6 (2012): 1107-1111. https://doi.org/10.3892/etm.2012.724
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