|
1
|
Kuhajda FP: Fatty-acid synthase and human
cancer: new perspectives on its role in tumor biology. Nutrition.
16:202–208. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Takahiro T, Shinichi K and Toshimitsu S:
Expression of fatty acid synthase as a prognostic indicator in soft
tissue sarcomas. Clin Cancer Res. 9:2204–2212. 2003.PubMed/NCBI
|
|
3
|
Menendez JA and Lupu R: Fatty acid
synthase and the lipogenic phenotype in cancer pathogenesis. Nat
Rev Cancer. 7:763–777. 2007. View
Article : Google Scholar : PubMed/NCBI
|
|
4
|
Van de Sande T, De SE, Heyns W, Verhoeven
G and Swinnen JV: Role of the phosphatidylinositol
3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty
acid synthase in LNCaP prostate cancer cells. Cancer Res.
62:642–646. 2002.
|
|
5
|
Escot C, Joyeux C, Mathieu M, Maudelonde
T, Pages A, Rochefort H and Chalbos D: Regulation of fatty acid
synthetase ribonucleic acid in the human endometrium during the
menstrual cycle. J Clin Endocrinol Metab. 70:1319–1324. 1990.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Rooney SA: Fatty acid biosynthesis in
developing fetal lung. Am J Physiol. 257:L195–L201. 1989.PubMed/NCBI
|
|
7
|
Joyeux C, Chalbos D and Rochefort H:
Effects of progestins and menstrual cycle on fatty acid synthetase
and progesterone receptor in human mammary glands. J Clin
Endocrinol Metab. 70:1438–1444. 1990. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Smith S and Ryan P: Asynchronous
appearance of two enzymes concerned with medium chain fatty acid
synthesis in developing rat mammary gland. J Biol Chem.
254:8932–8936. 1979.PubMed/NCBI
|
|
9
|
Chirala SS, Chang H, Matzuk M, et al:
Fatty acid synthesis is essential in embryonic development: fatty
acid synthase null mutants and most of the heterozygotes die in
utero. Proc Natl Acad Sci USA. 100:6358–6363. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Alo PL, Visca P, Trombetta G, et al: Fatty
acid synthase (FAS) predictive strength in poorly differentiated
early breast carcinomas. Tumori. 85:35–40. 1999.PubMed/NCBI
|
|
11
|
Shurbaji MS, Pasternack GR and Kuhajda FP:
Expression of haptoglobin-related protein in primary and metastatic
breast cancers. A longitudinal study of 48 fatal tumors. Am J Clin
Pathol. 96:238–242. 1991.PubMed/NCBI
|
|
12
|
Nguyen PL, Ma J, Chavarro JE, et al: Fatty
acid synthase polymorphisms, tumor expression, body mass index,
prostate cancer risk, and survival. J Clin Oncol. 28:3958–3964.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Shurbaji MS, Kuhajda FP, Pasternack GR and
Thurmond TS: Expression of oncogenic antigen 519 (OA-519) in
prostate cancer is a potential prognostic indicator. Am J Clin
Pathol. 97:686–691. 1992.PubMed/NCBI
|
|
14
|
Gansler TS, Hardman W III, Hunt DA,
Schaffel S and Hennigar RA: Increased expression of fatty acid
synthase (OA-519) in ovarian neoplasms predicts shorter survival.
Hum Pathol. 28:686–692. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Rashid A, Pizer ES, Moga M, et al:
Elevated expression of fatty acid synthase and fatty acid synthetic
activity in colorectal neoplasia. Am J Pathol. 150:201–208.
1997.PubMed/NCBI
|
|
16
|
Uddin S, Hussain AR, Ahmed M, et al: High
prevalence of fatty acid synthase expression in colorectal cancers
in Middle Eastern patients and its potential role as a therapeutic
target. Am J Gastroenterol. 104:1790–1801. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Epstein JI, Carmichael M and Partin AW:
OA-519 (fatty acid synthase) as an independent predictor of
pathologic state in adenocarcinoma of the prostate. Urology.
45:81–86. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
De SE, Brusselmans K, Heyns W, Verhoeven G
and Swinnen JV: RNA interference-mediated silencing of the fatty
acid synthase gene attenuates growth and induces morphological
changes and apoptosis of LNCaP prostate cancer cells. Cancer Res.
63:3799–3804. 2003.
|
|
19
|
Menendez JA, Colomer R and Lupu R:
Inhibition of tumor-associated fatty acid synthase activity
enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic
cell death in human breast cancer cells. Oncol Rep. 12:411–422.
2004.
|
|
20
|
Menendez JA, Vellon L, Colomer R and Lupu
R: Pharmacological and small interference RNA-mediated inhibition
of breast cancer-associated fatty acid synthase (oncogenic
antigen-519) synergistically enhances Taxol (paclitaxel)-induced
cytotoxicity. Int J Cancer. 115:19–35. 2005. View Article : Google Scholar
|
|
21
|
Hashimoto T, Kusakabe T, Sugino T, et al:
Expression of heart-type fatty acid-binding protein in human
gastric carcinoma and its association with tumor aggressiveness,
metastasis and poor prognosis. Pathobiology. 71:267–273. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Kusakabe T, Nashimoto A, Honma K and
Suzuki T: Fatty acid synthase is highly expressed in carcinoma,
adenoma and in regenerative epithelium and intestinal metaplasia of
the stomach. Histopathology. 40:71–79. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Enzinger FM and Weiss SW: Soft Tissue
Tumors. 3rd edition. Mosby-Year Book, Inc; St. Louis, MO: pp. 4–12.
1995
|
|
24
|
Bandyopadhyay S, Pai SK, Watabe M, et al:
FAS expression inversely correlates with PTEN level in prostate
cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to
induce apoptosis. Oncogene. 24:5389–5395. 2005. View Article : Google Scholar
|
|
25
|
Graner E, Tang D, Rossi S, et al: The
isopeptidase USP2a regulates the stability of fatty acid synthase
in prostate cancer. Cancer Cell. 5:253–261. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Flavin R, Peluso S, Nguyen PL and Loda M:
Fatty acid synthase as a potential therapeutic target in cancer.
Future Oncol. 6:551–562. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Kridel SJ, Lowther WT and Pemble CW: Fatty
acid synthase inhibitors: new directions for oncology. Expert Opin
Investig Drugs. 16:1817–1829. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Kuhajda FP: Fatty acid synthase and
cancer: new application of an old pathway. Cancer Res.
66:5977–5980. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Pizer ES, Wood FD, Heine HS, Romantsev FE,
Pasternack GR and Kuhajda FP: Inhibition of fatty acid synthesis
delays disease progression in a xenograft model of ovarian cancer.
Cancer Res. 56:1189–1193. 1996.PubMed/NCBI
|
|
30
|
Pizer ES, Jackisch C, Wood FD, Pasternack
GR, Davidson NE and Kuhajda FP: Inhibition of fatty acid synthesis
induces programmed cell death in human breast cancer cells. Cancer
Res. 56:2745–2747. 1996.PubMed/NCBI
|
