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Article

Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer

  • Authors:
    • Qiong Hu
    • Xuefei Li
    • Chunxia Su
    • Xiaoxia Chen
    • Guanghui Gao
    • Jie Zhang
    • Yinmin Zhao
    • Jiayu Li
    • Caicun Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China, Tongji University Medical School Cancer Institute, Shanghai 200433, P.R. China
  • Pages: 1010-1016
    |
    Published online on: September 28, 2012
       https://doi.org/10.3892/etm.2012.730
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Abstract

One of the target genes of pemetrexed (PEM), thymidylate synthase (TS), has been shown to have a close association with its efficacy. TS gene polymorphisms have been shown to be associated with the efficacy of antifolate treatment in enteron tumors. The purpose of this study was to investigate the clinical significance of TS gene polymorphisms in patients with advanced NSCLC receiving PEM-based treatment. The variable nucleoid tandem repeat in the 5'-UTR region was amplified and detected using fluorescently labeled multiplex short tandem repeat polymerase chain reaction. The polymorphism in the 3'-UTR region of the TS gene was detected using the Taqman probe. Efficacy of PEM was assessed according to the Response Evaluation Criteria in Solid Tumors, version 1.1. None of the genotypes were associated with gender, smoking status and age. Disease control rate (DCR), objective response rate (ORR) and progression-free survival (PFS) were similar between patients harboring 2R and 3R alleles (PFS, p=0.518; DCR, p=0.631; ORR, p=0.541), as well as those with a 6‑bp insertion and 6‑bp deletion (PFS, p=0.776; DCR, p=0.626; ORR, p=0.330). To study the combined effect of TS polymorphisms, the study population was divided into three groups: 2R&6 del, 2R&6 ins and 3R&6 del. No significant differences were observed among the different groups according to DCR (p=0.517), ORR (p=0.611) and PFS (p=0.938). In conclusion, polymorphisms of the TS gene do not appear to be a prognostic marker for advanced NSCLC patients receiving PEM-based treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Hu Q, Li X, Su C, Chen X, Gao G, Zhang J, Zhao Y, Li J and Zhou C: Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer. Exp Ther Med 4: 1010-1016, 2012.
APA
Hu, Q., Li, X., Su, C., Chen, X., Gao, G., Zhang, J. ... Zhou, C. (2012). Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer. Experimental and Therapeutic Medicine, 4, 1010-1016. https://doi.org/10.3892/etm.2012.730
MLA
Hu, Q., Li, X., Su, C., Chen, X., Gao, G., Zhang, J., Zhao, Y., Li, J., Zhou, C."Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer". Experimental and Therapeutic Medicine 4.6 (2012): 1010-1016.
Chicago
Hu, Q., Li, X., Su, C., Chen, X., Gao, G., Zhang, J., Zhao, Y., Li, J., Zhou, C."Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer". Experimental and Therapeutic Medicine 4, no. 6 (2012): 1010-1016. https://doi.org/10.3892/etm.2012.730
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Q, Li X, Su C, Chen X, Gao G, Zhang J, Zhao Y, Li J and Zhou C: Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer. Exp Ther Med 4: 1010-1016, 2012.
APA
Hu, Q., Li, X., Su, C., Chen, X., Gao, G., Zhang, J. ... Zhou, C. (2012). Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer. Experimental and Therapeutic Medicine, 4, 1010-1016. https://doi.org/10.3892/etm.2012.730
MLA
Hu, Q., Li, X., Su, C., Chen, X., Gao, G., Zhang, J., Zhao, Y., Li, J., Zhou, C."Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer". Experimental and Therapeutic Medicine 4.6 (2012): 1010-1016.
Chicago
Hu, Q., Li, X., Su, C., Chen, X., Gao, G., Zhang, J., Zhao, Y., Li, J., Zhou, C."Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer". Experimental and Therapeutic Medicine 4, no. 6 (2012): 1010-1016. https://doi.org/10.3892/etm.2012.730
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