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Article

PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis

  • Authors:
    • Xin Xu
    • Yanqi Xie
    • Yiwei Lin
    • Xianglai Xu
    • Yi Zhu
    • Yeqing Mao
    • Zhenghui Hu
    • Jian  Wu
    • Hong Chen
    • Xiangyi Zheng
    • Jie Qin
    • Liping Xie
  • View Affiliations / Copyright

    Affiliations: Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 1127-1133
    |
    Published online on: October 2, 2012
       https://doi.org/10.3892/etm.2012.734
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Abstract

Plasminogen activator inhibitor-1 (PAI-1), belonging to the urokinase plasminogen activation (uPA) system, is involved in cancer development and progression. The PAI-1 promoter 4G/5G polymorphism was shown to contribute to genetic susceptibility to cancer, although the results were inconsistent. To assess this relationship more precisely, a meta-analysis was performed. The electronic databases PubMed, Scopus, Web of Science and Chinese National Knowledge Infrastructure (CNKI) were searched; data were extracted and analyzed independently by two reviewers. Ultimately, 21 eligible case-control studies with a total of 8,415 cancer cases and 9,208 controls were included. The overall odds ratio (OR) with its 95% confidence interval (CI) showed a statistically significant association between the PAI-1 promoter 4G/5G polymorphism and cancer risk (4G/4G vs. 5G/5G: OR=1.25, 95% CI=1.07-1.47, Pheterogeneity=0.001; 4G/4G vs. 4G/5G+5G/5G: OR=1.10, 95% CI=1.03-1.17, Pheterogeneity=0.194; 4G/4G+4G/5G vs. 5G/5G: OR=1.17, 95% CI=1.01-1.35, Pheterogeneity=0.041). In further subgroup analyses, the increased risk of cancer was observed in a subgroup of Caucasians with regards to endometrial cancer. Our meta-analysis suggests that the PAI-1 4G/5G polymorphism most likely contributes to susceptibility to cancer, particularly in Caucasians. Furthermore, the 4G allele may be associated with an increased risk of endometrial cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Xie Y, Lin Y, Xu X, Zhu Y, Mao Y, Hu Z, Wu J, Chen H, Zheng X, Zheng X, et al: PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis. Exp Ther Med 4: 1127-1133, 2012.
APA
Xu, X., Xie, Y., Lin, Y., Xu, X., Zhu, Y., Mao, Y. ... Xie, L. (2012). PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis. Experimental and Therapeutic Medicine, 4, 1127-1133. https://doi.org/10.3892/etm.2012.734
MLA
Xu, X., Xie, Y., Lin, Y., Xu, X., Zhu, Y., Mao, Y., Hu, Z., Wu, J., Chen, H., Zheng, X., Qin, J., Xie, L."PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis". Experimental and Therapeutic Medicine 4.6 (2012): 1127-1133.
Chicago
Xu, X., Xie, Y., Lin, Y., Xu, X., Zhu, Y., Mao, Y., Hu, Z., Wu, J., Chen, H., Zheng, X., Qin, J., Xie, L."PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis". Experimental and Therapeutic Medicine 4, no. 6 (2012): 1127-1133. https://doi.org/10.3892/etm.2012.734
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Xie Y, Lin Y, Xu X, Zhu Y, Mao Y, Hu Z, Wu J, Chen H, Zheng X, Zheng X, et al: PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis. Exp Ther Med 4: 1127-1133, 2012.
APA
Xu, X., Xie, Y., Lin, Y., Xu, X., Zhu, Y., Mao, Y. ... Xie, L. (2012). PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis. Experimental and Therapeutic Medicine, 4, 1127-1133. https://doi.org/10.3892/etm.2012.734
MLA
Xu, X., Xie, Y., Lin, Y., Xu, X., Zhu, Y., Mao, Y., Hu, Z., Wu, J., Chen, H., Zheng, X., Qin, J., Xie, L."PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis". Experimental and Therapeutic Medicine 4.6 (2012): 1127-1133.
Chicago
Xu, X., Xie, Y., Lin, Y., Xu, X., Zhu, Y., Mao, Y., Hu, Z., Wu, J., Chen, H., Zheng, X., Qin, J., Xie, L."PAI-1 promoter 4G/5G polymorphism (rs1799768) contributes to tumor susceptibility: Evidence from meta-analysis". Experimental and Therapeutic Medicine 4, no. 6 (2012): 1127-1133. https://doi.org/10.3892/etm.2012.734
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