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Article

Loss and reduced expression of PTEN correlate with advanced‑stage gastric carcinoma

  • Authors:
    • Xuehua Zhu
    • Xia Qin
    • Maogui Fei
    • Wenmin Hou
    • Joel Greshock
    • Kurtis E. Bachman
    • Jiuhong Kang
    • Crystal Ying Qin
  • View Affiliations / Copyright

    Affiliations: Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, P.R. China, Department of Oncology, GlaxoSmithKline Research and Development Center, Shanghai, P.R. China , Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences (CAS), Shanghai, P.R. China, Cancer Research, GlaxoSmithKline, Collegeville, PA, USA
  • Pages: 57-64
    |
    Published online on: October 15, 2012
       https://doi.org/10.3892/etm.2012.749
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Abstract

Phosphatase and tensin homolog (PTEN) is a tumor suppressor involved in multiple cell processes. To investigate the role of PTEN in the development of gastric carcinoma, we determined the expression pattern of PTEN in primary gastric carcinoma and in paired adjacent non‑neoplastic tissue. We also determined the correlation of PTEN expression with clinicopathological characteristics and patient survival. Overall, 159 gastric carcinomas and 151 paired adjacent non‑neoplastic tissues were used in the present study. PTEN expression was determined using tissue microarrays and immunohistochemistry. The clinical sensitivity and specificity of PTEN expression were calculated using receiver operator characteristic curves. Results showed that the loss of cytoplasmic PTEN was significantly more frequent in carcinoma tissue compared with adjacent non‑neoplastic tissue (62 vs. 5%, respectively; P<0.0001). PTEN expression was markedly downregulated in carcinoma tissues compared with adjacent non‑neoplastic tissues. The loss of cytoplasmic PTEN expression was positively correlated with histological stage (P=0.016). The loss of nuclear or total PTEN, and downregulation of total PTEN expression, was significantly different between American Joint Committee on Cancer tumors of stage I and stages II-IV. A low cytoplasmic or total PTEN expression showed high clinical sensitivity and specificity for gastric carcinoma. However, PTEN expression was not significantly associated with overall or 3‑year survival rates. The findings of the present study indicated that PTEN expression may be a molecular diagnostic marker for gastric cancer. Thus, the loss or reduced expression of PTEN potentially correlate with advanced stages of gastric carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu X, Qin X, Fei M, Hou W, Greshock J, Bachman KE, Kang J and Qin CY: Loss and reduced expression of PTEN correlate with advanced‑stage gastric carcinoma. Exp Ther Med 5: 57-64, 2013.
APA
Zhu, X., Qin, X., Fei, M., Hou, W., Greshock, J., Bachman, K.E. ... Qin, C.Y. (2013). Loss and reduced expression of PTEN correlate with advanced‑stage gastric carcinoma. Experimental and Therapeutic Medicine, 5, 57-64. https://doi.org/10.3892/etm.2012.749
MLA
Zhu, X., Qin, X., Fei, M., Hou, W., Greshock, J., Bachman, K. E., Kang, J., Qin, C. Y."Loss and reduced expression of PTEN correlate with advanced‑stage gastric carcinoma". Experimental and Therapeutic Medicine 5.1 (2013): 57-64.
Chicago
Zhu, X., Qin, X., Fei, M., Hou, W., Greshock, J., Bachman, K. E., Kang, J., Qin, C. Y."Loss and reduced expression of PTEN correlate with advanced‑stage gastric carcinoma". Experimental and Therapeutic Medicine 5, no. 1 (2013): 57-64. https://doi.org/10.3892/etm.2012.749
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X, Qin X, Fei M, Hou W, Greshock J, Bachman KE, Kang J and Qin CY: Loss and reduced expression of PTEN correlate with advanced‑stage gastric carcinoma. Exp Ther Med 5: 57-64, 2013.
APA
Zhu, X., Qin, X., Fei, M., Hou, W., Greshock, J., Bachman, K.E. ... Qin, C.Y. (2013). Loss and reduced expression of PTEN correlate with advanced‑stage gastric carcinoma. Experimental and Therapeutic Medicine, 5, 57-64. https://doi.org/10.3892/etm.2012.749
MLA
Zhu, X., Qin, X., Fei, M., Hou, W., Greshock, J., Bachman, K. E., Kang, J., Qin, C. Y."Loss and reduced expression of PTEN correlate with advanced‑stage gastric carcinoma". Experimental and Therapeutic Medicine 5.1 (2013): 57-64.
Chicago
Zhu, X., Qin, X., Fei, M., Hou, W., Greshock, J., Bachman, K. E., Kang, J., Qin, C. Y."Loss and reduced expression of PTEN correlate with advanced‑stage gastric carcinoma". Experimental and Therapeutic Medicine 5, no. 1 (2013): 57-64. https://doi.org/10.3892/etm.2012.749
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