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Article

Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice

  • Authors:
    • Guocai Li
    • Lunxiu Qin
    • Qinghai Ye
    • Qiongzhu Dong
    • Ning Ren
    • Huliang Jia
  • View Affiliations / Copyright

    Affiliations: Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
  • Pages: 133-137
    |
    Published online on: October 18, 2012
       https://doi.org/10.3892/etm.2012.752
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Abstract

The interaction between cancer and the organ microenvironment is complex, and the transforming growth factor-β (TGF-β)/Smad pathway plays an important role in this interaction. However, the role of the organ microenvironment in hepatocellular carcinoma (HCC) is not well understood. To evaluate the effect of the organ microenvironment and the role of the TGF-β/Smad pathway, MHCC97-H cells were inoculated subcutaneously into nude mice and the resulting MHCC97-H subcutaneous tumor tissues were implanted into the livers of the mice. We found a higher tumor weight and less pulmonary metastasis for the cancers in liver sites than for those in subcutaneous sites; the TGF-β1 levels were significantly different between the tumor models and correlated with tumor metastasis. Our results suggest that the organ microenvironment affects the growth and invasion of liver cancer cells. The TGF-β/Smad pathway is significant in the interaction between HCC and its microenvironment and affects the progression of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Li G, Qin L, Ye Q, Dong Q, Ren N and Jia H: Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice. Exp Ther Med 5: 133-137, 2013.
APA
Li, G., Qin, L., Ye, Q., Dong, Q., Ren, N., & Jia, H. (2013). Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice. Experimental and Therapeutic Medicine, 5, 133-137. https://doi.org/10.3892/etm.2012.752
MLA
Li, G., Qin, L., Ye, Q., Dong, Q., Ren, N., Jia, H."Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice". Experimental and Therapeutic Medicine 5.1 (2013): 133-137.
Chicago
Li, G., Qin, L., Ye, Q., Dong, Q., Ren, N., Jia, H."Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice". Experimental and Therapeutic Medicine 5, no. 1 (2013): 133-137. https://doi.org/10.3892/etm.2012.752
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Qin L, Ye Q, Dong Q, Ren N and Jia H: Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice. Exp Ther Med 5: 133-137, 2013.
APA
Li, G., Qin, L., Ye, Q., Dong, Q., Ren, N., & Jia, H. (2013). Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice. Experimental and Therapeutic Medicine, 5, 133-137. https://doi.org/10.3892/etm.2012.752
MLA
Li, G., Qin, L., Ye, Q., Dong, Q., Ren, N., Jia, H."Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice". Experimental and Therapeutic Medicine 5.1 (2013): 133-137.
Chicago
Li, G., Qin, L., Ye, Q., Dong, Q., Ren, N., Jia, H."Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice". Experimental and Therapeutic Medicine 5, no. 1 (2013): 133-137. https://doi.org/10.3892/etm.2012.752
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