Therapeutic effects of calcium dobesilate on diabetic nephropathy mediated through reduction of expression of PAI‑1
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Affiliations: Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, P.R. China
- Published online on: October 19, 2012 https://doi.org/10.3892/etm.2012.755
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295-299
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Abstract
The aim of this study was to investigate whether calcium dobesilate (calcium dihydroxy‑2,5‑benzenesulfonate) may be used to treat diabetic nephropathy. A total of 121 patients with type 2 diabetic nephropathy received calcium dobesilate (500 mg, 3 times a day) for 3 months. The levels of glycated hemoglobin, fasting serum C peptide, triglyceride, total cholesterol, low‑density lipoprotein cholesterol, high‑density lipoprotein cholesterol, alanine aminotransferase, γ-glutamyl transferase, urea nitrogen, creatinine, hematocrit, plasma viscosity, whole blood reduced viscosity, high, medium and low shear rate whole blood viscosity, fibrinogen, plasminogen activator inhibitor‑1 (PAI‑1) and endothelin were determined. The urinary albumin excretion rate (UAER) was also determined once a month during the study. The UAER and medium and low shear rate whole blood viscosity were significantly lower in the treated patients. The rate of microalbuminuria normalization was 90%. During the treatment, the UAERs decreased. The results revealed that calcium dobesilate has therapeutic effects on type 2 diabetes patients with microalbuminuria. In addition, the benefit was positively correlated with the calcium dobesilate treatment time. The therapeutic effect may be due to decreases in the levels of PAI‑1.
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