Analysis of the expression of KIR and HLA‑Cw in a Northeast Han population

  • Authors:
    • Yu Han
    • Ling Zhao
    • Zhenyu Jiang
    • Ning Ma
  • View Affiliations

  • Published online on: October 25, 2012     https://doi.org/10.3892/etm.2012.763
  • Pages: 300-304
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Abstract

The aim of this study was to investigate the expression of the human leukocyte antigen (HLA)‑Cw and killer cell immunoglobulin‑like receptor (KIR) genes in a Jilin Han population and to provide a theoretical basis for further studies of their roles in disease. A total of 154 unpaid Jilin Han blood donors were selected and KIR and HLA‑Cw genotyping was performed using PCR‑SSP. Recognition of HLA‑Cw and the corresponding activatory or inhibitory KIR receptor was distinguished according to the identification of HLA‑Cw and KIR. In the present study, the expression frequency of HLA‑C2Lys80+2DL1 was 27.27%, HLA‑C1Asn80+2DL2/2DL3 was 68.83%, 2DS2+HLA‑C1Asn80 was 9.74% and 2DS1+HLA‑C2Lys80 was 9.74%. Of the individuals in the study, 72.08% expressed only KIR2DL1 without HLA‑Cw, 21.43% expressed only KIR2DS1 without HLA‑CwLys‑KIR2DL1 and 2.60% expressed only KIR2DS2 without HLA‑CwAsn‑KIR2DL2/L3. In conclusion, the expression of inhibitory HLA‑Cw‑KIR is higher than the expression of activating HLA‑Cw‑KIR and approximately 20% of the individuals separately expressed the activated HLA‑Cw‑KIR in the Jilin Han population in the present study.
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January 2013
Volume 5 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Han Y, Zhao L, Jiang Z and Ma N: Analysis of the expression of KIR and HLA‑Cw in a Northeast Han population. Exp Ther Med 5: 300-304, 2013
APA
Han, Y., Zhao, L., Jiang, Z., & Ma, N. (2013). Analysis of the expression of KIR and HLA‑Cw in a Northeast Han population. Experimental and Therapeutic Medicine, 5, 300-304. https://doi.org/10.3892/etm.2012.763
MLA
Han, Y., Zhao, L., Jiang, Z., Ma, N."Analysis of the expression of KIR and HLA‑Cw in a Northeast Han population". Experimental and Therapeutic Medicine 5.1 (2013): 300-304.
Chicago
Han, Y., Zhao, L., Jiang, Z., Ma, N."Analysis of the expression of KIR and HLA‑Cw in a Northeast Han population". Experimental and Therapeutic Medicine 5, no. 1 (2013): 300-304. https://doi.org/10.3892/etm.2012.763