Analysis of the expression of KIR and HLA‑Cw in a Northeast Han population

Han,Yu; Zhao,Ling; Jiang,Zhenyu; Ma,Ning

doi:10.3892/etm.2012.763

January 2013 Volume 5 Issue 1

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January 2013 Volume 5 Issue 1

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Article

Analysis of the expression of KIR and HLA‑Cw in a Northeast Han population

Authors:
- Yu Han
- Ling Zhao
- Zhenyu Jiang
- Ning Ma
View Affiliations / Copyright

Affiliations: Jilin Blood Center, Changchun, Jilin 130033, P.R. China, Department of Rheumatology, First Hospital, Jilin Unversity, Changchun 130021, P.R. China
Pages: 300-304
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Published online on: October 25, 2012

https://doi.org/10.3892/etm.2012.763
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Abstract

The aim of this study was to investigate the expression of the human leukocyte antigen (HLA)‑Cw and killer cell immunoglobulin‑like receptor (KIR) genes in a Jilin Han population and to provide a theoretical basis for further studies of their roles in disease. A total of 154 unpaid Jilin Han blood donors were selected and KIR and HLA‑Cw genotyping was performed using PCR‑SSP. Recognition of HLA‑Cw and the corresponding activatory or inhibitory KIR receptor was distinguished according to the identification of HLA‑Cw and KIR. In the present study, the expression frequency of HLA‑C2Lys80+2DL1 was 27.27%, HLA‑C1Asn80+2DL2/2DL3 was 68.83%, 2DS2+HLA‑C1Asn80 was 9.74% and 2DS1+HLA‑C2Lys80 was 9.74%. Of the individuals in the study, 72.08% expressed only KIR2DL1 without HLA‑Cw, 21.43% expressed only KIR2DS1 without HLA‑CwLys‑KIR2DL1 and 2.60% expressed only KIR2DS2 without HLA‑CwAsn‑KIR2DL2/L3. In conclusion, the expression of inhibitory HLA‑Cw‑KIR is higher than the expression of activating HLA‑Cw‑KIR and approximately 20% of the individuals separately expressed the activated HLA‑Cw‑KIR in the Jilin Han population in the present study.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Analysis of the expression of KIR and HLA‑Cw in a Northeast Han population

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