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Article

FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage

  • Authors:
    • Yan He
    • Qiang-Chuan Qu
    • Bang-Xing Wang
    • Feng-Yi Du
    • Zhi-Hong Guo
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong 250012 P.R. China
  • Pages: 223-228
    |
    Published online on: October 26, 2012
       https://doi.org/10.3892/etm.2012.770
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Abstract

This study was designed to observe the role of FOS protein expression in the rat medullary visceral zone (MVZ) in multiple organ dysfunction syndrome (MODS) caused by subarachnoid hemorrhage (SAH), with and without severing the vagus nerve. We also investigated the regulatory and control mechanisms of the MVZ and the vagus nerve in MODS following SAH. A model of MODS following SAH was established by injecting arterial blood into the Willis' circle. The vagus nerve was cut off and blocked. The FOS protein expression in the MVZ was detected by immunohistochemistry. The positive expression levels of FOS in the MVZ in the SAH and SAH + severed-down vagus nerve (SDV) groups were higher than those in the normal control, sham surgery and SDV groups (P<0.01). However, expression in the SAH+SDV group was lower than that in the SAH group (P<0.01). Inflammatory damage was observed in each visceral organ at every time‑phased point in the SAH group and the SAH+SDV group. The most apparent damage was at 24-36 h, consistent with the peak of FOS protein expression; the SAH+SDV group presented a greater level of damage. The inflammatory changes in surrounding visceral organs following SAH correlated with FOS protein expression in the MVZ, which indicates that the MVZ participates in the functional control of surrounding visceral organs following SAH. Severing the subphrenic vagus nerve increases the incidence of MODS following SAH and enhances SAH-induced inflammatory damage to the surrounding visceral organs, which indicates that the vagus nerve plays a role in the protection of the surrounding visceral organs in MODS following SAH.
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1 

Bone RC, Balk RA, Cerra FB, et al: Definitions for sepis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee American College of Chest Physicians/Society of Critical Care Medicine. Chest. 101:1644–1655. 1992. View Article : Google Scholar

2 

Bhatia M, Wong FL, Cao Y, et al: Pathophysiology of acute pancreatitis. Pancreatology. 5:132–144. 2005. View Article : Google Scholar

3 

Kaczorowski DJ, Mollen KP, Edmonds R and Billiar TR: Early events in the recognition of danger signals after tissue injury. J Leukoc Biol. 83:546–552. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Romero CM, Downey P and Hernández G: High volume hemofiltration in septic shock. Med Intensiva. 34:345–352. 2010.(In Spanish).

5 

Reinhart K, Menges T, Gardlund B, et al: Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyper inflammatory response during severe sepsis: the RAMSES study. Crit Care Med. 29:765–769. 2006. View Article : Google Scholar

6 

Jiang LY, Yang ZF and Yang LH: Analysis of acute cerebral arterial thrombosis with multiple organ dysfunction syndrome. Nan Fang Yi Ke Da Xue Xue Bao. 27:1215–1217. 2007.(In Chinese).

7 

Qu C, Guo S, Guo H, et al: Increased serum endotoxin and elevated CD14 and IL-1beta expression in a rat model of cerebrogenic multiple organ dysfunction syndrome. Med Chem. 5:462–467. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Bitto A, Polito F, Altavilla D, et al: Melanocortins protect against multiple organ dysfunction syndrome in mice. Br J Pharmacol. 162:917–928. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Goldstein RS, Gallowitsch-Puerta M, Yang L, et al: Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia. Shock. 25:571–574. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Yang ZJ, Rao ZR and Ju G: Evidence for the medullary visceral zone as a neural station of neuroimmunomodulation. Neurosci Res. 38:237–247. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Jia HG, Rao ZR and Shi JW: Projection from the ventrolateral medullary neurons containing tyrosine hydroxylase to the central amygdaloid nucleus in rat brain. Brain Res. 589:167–172. 1992. View Article : Google Scholar : PubMed/NCBI

12 

Mioni C, Bazzani C and Giuliani D: Activation of efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats. Crit Care Med. 33:2621–2628. 2005. View Article : Google Scholar

13 

Dellinger RP, Levy MM, Cadet JM, et al: Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 36:296–327. 2008. View Article : Google Scholar

14 

Van Der Zanden EP, Boeckxstaens GE and de Jonge WJ: The vagus nerve as a modulator of intestinal inflammation. Neurogastroenterol Motil. 21:6–17. 2009.PubMed/NCBI

15 

Parrish WR, Rosas-Ballina M, Gallowitsch-Puerta M, et al: Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling. Mol Med. 6:232–241. 2008.PubMed/NCBI

16 

Prunell GF, Mathiesen T, Diemer NH and Svendgaard NA: Experimental subarachnoid hemorrhage; subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow and perfusion pressure in three different rat models. Neurosurgery. 52:165–175. 2003.

17 

Bullitt E: Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat. J Comp Neurol. 296:517–530. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Jedynak JP, Cameron CM and Robinson TE: Repeated methamphetamine administration differentially alters Fos expression in caudate-putamen patch and matrix compartments and nucleus accumbens. PLoS One. 7:e342272012. View Article : Google Scholar

19 

Sun YN, Luo JY, Rao ZR, Lan L and Duan L: GFAP and Fos immunoreactivity in lumbo-sacral spinal cord and medulla oblongata after chronic colonic inflammation in rats. World J Gastroenterol. 11:4827–4832. 2005.PubMed/NCBI

20 

Zhao DQ, Lu CL and Ai HB: The role of catecholaminergic neurons in the hypothalamus and medullary visceral zone in response to restraint water-immersion stress in rats. J Physiol Sci. 61:37–45. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Richerson GB and Getting PA: Medullary respiratory neurons in the guinea pig: localization and firing patterns. Brain Res. 591:79–87. 1992. View Article : Google Scholar : PubMed/NCBI

22 

Gao W, Liu H, Rao Z and Ju G: Distribution of SPR-like immunoreactivity in the medullary visceral zone of the rat and changes following acute myocardial ischemia induced by intravenous injection of vasopressin. J Hirnforsch. 39:129–135. 1998.PubMed/NCBI

23 

Ge X, Yang Z, Duan L and Rao Z: Evidence for involvement of the neural pathway containing the peripheral vagus nerve, medullary visceral zone and central amygdaloid nucleus in neuroimmunomodulation. Brain Res. 914:149–158. 2001. View Article : Google Scholar

24 

Hildebrand F, Pape HC and Krettek C: The importance of cytokines in the posttraumatic inflammatory reaction. Unfallchirurg. 108:793–794. 796–803. 2005.(In German).

25 

Kawada T, Yamazaki T, Akiyama T, et al: Vagal stimulation suppresses ischemia induced myocardial interstitial norepinephrine release. Life Sci. 78:882–887. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Borovikova LV, Ivanova S, Zhang M, et al: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 405:458–462. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Tracey KJ: The inflammatory reflex. Nature. 420:853–859. 2002. View Article : Google Scholar

28 

Barnum SR, Ames RS, Maycox PR, et al: Expression of the complement C3a and C5a receptors after permanent focal ischemia: an alternative interpretation. Glia. 38:169–173. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Kim HM, Shin HJ, Jeong HJ, et al: Reduced IL-2 but elevated IL-4, IL-6 and IgE serum levels in patients with cerebral infarction during the acute stage. J Mol Neurosci. 14:191–196. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Hansen MK, Nguyen KT, Fleshner M, et al: Effects of vagotomy on serum endotoxin, cytokines and corticosterone after intraperitoneal lipopolysaccharide. Am J Physiol Regul Integr Comp Physiol. 278:R331–R336. 2000.

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Copy and paste a formatted citation
Spandidos Publications style
He Y, Qu Q, Wang B, Du F and Guo Z: FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage. Exp Ther Med 5: 223-228, 2013.
APA
He, Y., Qu, Q., Wang, B., Du, F., & Guo, Z. (2013). FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage. Experimental and Therapeutic Medicine, 5, 223-228. https://doi.org/10.3892/etm.2012.770
MLA
He, Y., Qu, Q., Wang, B., Du, F., Guo, Z."FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage". Experimental and Therapeutic Medicine 5.1 (2013): 223-228.
Chicago
He, Y., Qu, Q., Wang, B., Du, F., Guo, Z."FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage". Experimental and Therapeutic Medicine 5, no. 1 (2013): 223-228. https://doi.org/10.3892/etm.2012.770
Copy and paste a formatted citation
x
Spandidos Publications style
He Y, Qu Q, Wang B, Du F and Guo Z: FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage. Exp Ther Med 5: 223-228, 2013.
APA
He, Y., Qu, Q., Wang, B., Du, F., & Guo, Z. (2013). FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage. Experimental and Therapeutic Medicine, 5, 223-228. https://doi.org/10.3892/etm.2012.770
MLA
He, Y., Qu, Q., Wang, B., Du, F., Guo, Z."FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage". Experimental and Therapeutic Medicine 5.1 (2013): 223-228.
Chicago
He, Y., Qu, Q., Wang, B., Du, F., Guo, Z."FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage". Experimental and Therapeutic Medicine 5, no. 1 (2013): 223-228. https://doi.org/10.3892/etm.2012.770
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