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Article

Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study

  • Authors:
    • Stella Maria Pedrossian Vecchiatti
    • Maria Luisa Guzzo
    • Elia Garcia Caldini
    • Hélio Bisi
    • Adhemar Longatto-Filho
    • Chin Jia Lin
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, University of São Paulo School of Medicine, São Paulo, Brazil, Bioterism Center of University of São Paulo School of Medicine, São Paulo, Brazil, Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of São Paulo, São Paulo, Brazil
  • Pages: 603-607
    |
    Published online on: November 22, 2012
       https://doi.org/10.3892/etm.2012.826
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Abstract

Prolonged intake of large amounts of iodine has been reported to increase the incidence of hypothyroidism in humans, as well as in animals which are prone to spontaneously developing autoimmune thyroiditis. We sought to investigate the histopathological consequences of large amounts of dietary iodine on the thyroid gland and observe the occurrence of lymphocytic infiltration associated with the time of exposure to iodine. An experimental model using non‑obese diabetic (NOD) mice was analyzed. A potassium iodide intake of 0.2 mg/animal/day was administered via drinking water, in experimental groups of 60 and 90 days (EG60 and EG90). Distended rough endoplasmic reticulum, degenerated mitochondria, debris and amorphous spaces or ‘ill-defined’ spaces were observed with electron microscopy (EM). Lymphocyte infiltration was observed in the two groups and the time of exposure to iodine did not increase the appearance of lymphocyte infiltration but significantly associated with the development of necrosis. The results of the present study demonstrated that the NOD mouse is a feasible experimental model for thyroiditis induced by iodine administration and may represent an opportunity to analyze the steps and factors associated with genetic autoimmune thyroiditis. High doses of ingested iodine were observed to precdict and increase the incidence of the thyroiditis process.
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Copy and paste a formatted citation
Spandidos Publications style
Vecchiatti SM, Guzzo ML, Caldini EG, Bisi H, Longatto-Filho A and Lin CJ: Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study. Exp Ther Med 5: 603-607, 2013.
APA
Vecchiatti, S.M., Guzzo, M.L., Caldini, E.G., Bisi, H., Longatto-Filho, A., & Lin, C.J. (2013). Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study. Experimental and Therapeutic Medicine, 5, 603-607. https://doi.org/10.3892/etm.2012.826
MLA
Vecchiatti, S. M., Guzzo, M. L., Caldini, E. G., Bisi, H., Longatto-Filho, A., Lin, C. J."Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study". Experimental and Therapeutic Medicine 5.2 (2013): 603-607.
Chicago
Vecchiatti, S. M., Guzzo, M. L., Caldini, E. G., Bisi, H., Longatto-Filho, A., Lin, C. J."Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study". Experimental and Therapeutic Medicine 5, no. 2 (2013): 603-607. https://doi.org/10.3892/etm.2012.826
Copy and paste a formatted citation
x
Spandidos Publications style
Vecchiatti SM, Guzzo ML, Caldini EG, Bisi H, Longatto-Filho A and Lin CJ: Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study. Exp Ther Med 5: 603-607, 2013.
APA
Vecchiatti, S.M., Guzzo, M.L., Caldini, E.G., Bisi, H., Longatto-Filho, A., & Lin, C.J. (2013). Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study. Experimental and Therapeutic Medicine, 5, 603-607. https://doi.org/10.3892/etm.2012.826
MLA
Vecchiatti, S. M., Guzzo, M. L., Caldini, E. G., Bisi, H., Longatto-Filho, A., Lin, C. J."Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study". Experimental and Therapeutic Medicine 5.2 (2013): 603-607.
Chicago
Vecchiatti, S. M., Guzzo, M. L., Caldini, E. G., Bisi, H., Longatto-Filho, A., Lin, C. J."Iodine increases and predicts incidence of thyroiditis in NOD mice: Histopathological and ultrastructural study". Experimental and Therapeutic Medicine 5, no. 2 (2013): 603-607. https://doi.org/10.3892/etm.2012.826
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