Number and function of peripheral blood endothelial progenitor cells in Henoch-Schönlein purpura nephritis children with different degrees of renal vascular lesions

  • Authors:
    • Xi-Qiang Dang
    • Xiao-Jie He
    • Hai-Xia Chen
    • Qing-Nan He
    • Zhu-Wen Yi
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  • Published online on: December 18, 2012     https://doi.org/10.3892/etm.2012.863
  • Pages: 870-874
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Abstract

The aim of this study was to explore the correlation between different degrees of renal vascular lesions in children with Henoch-Schönlein purpura nephritis (HSPN) and changes in progenitor cell number and function in peripheral blood. Forty-eight HSPN patients were divided into three groups, mild, moderate and severe, according to the degree of renal vascular lesions. Peripheral blood mononuclear cells were isolated and cultured. Endothelial progenitor cells (EPCs) were identified by immunofluorescence assay. The number of EPCs and the migration and adhesion of EPCs were detected by flow cytometry. The numbers of peripheral blood CD34+, kinase insert domain receptor+ (KDR+) and CD133+ cells were lower in the severe and moderate vascular lesion groups compared with the mild vascular lesion group (all P<0.05) and were also lower in the severe vascular lesion group compared with the mild and moderate vascular lesion groups (all P<0.05). The adhesion and migration of EPCs were reduced in turn in the mild, moderate and severe groups. There were significant differences between the severe group and the mild and moderate groups (all P<0.05). Renal vascular lesions are involved in the occurrence and development of HSPN, while the number of EPCs, migration and adhesion of EPCs are important factors in renal vascular lesions.
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March 2013
Volume 5 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Dang X, He X, Chen H, He Q and Yi Z: Number and function of peripheral blood endothelial progenitor cells in Henoch-Schönlein purpura nephritis children with different degrees of renal vascular lesions. Exp Ther Med 5: 870-874, 2013
APA
Dang, X., He, X., Chen, H., He, Q., & Yi, Z. (2013). Number and function of peripheral blood endothelial progenitor cells in Henoch-Schönlein purpura nephritis children with different degrees of renal vascular lesions. Experimental and Therapeutic Medicine, 5, 870-874. https://doi.org/10.3892/etm.2012.863
MLA
Dang, X., He, X., Chen, H., He, Q., Yi, Z."Number and function of peripheral blood endothelial progenitor cells in Henoch-Schönlein purpura nephritis children with different degrees of renal vascular lesions". Experimental and Therapeutic Medicine 5.3 (2013): 870-874.
Chicago
Dang, X., He, X., Chen, H., He, Q., Yi, Z."Number and function of peripheral blood endothelial progenitor cells in Henoch-Schönlein purpura nephritis children with different degrees of renal vascular lesions". Experimental and Therapeutic Medicine 5, no. 3 (2013): 870-874. https://doi.org/10.3892/etm.2012.863