Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May 2013 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 2013 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage

  • Authors:
    • Xiaoshan Shi
    • Hongyun Li
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 1367-1370
    |
    Published online on: March 12, 2013
       https://doi.org/10.3892/etm.2013.1001
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

This aim of this study was to investigate the effects of intervention with low-molecular-weight heparin calcium on the pulmonary function and blood coagulation function of patients with chronic obstructive pulmonary disease (COPD) in the acute exacerbation stage. A total of 70 patients with COPD in the acute exacerbation stage were selected and randomly divided into the control group (32 cases) and the anticoagulation group (38 cases). The patients of the control group were treated with oxygen therapy, spasmolysis, asthmarelief, cough relief and sputum reduction. The patients in the anticoagulation group, in addition to the conventional therapy used the control group, were also treated with low‑molecular‑weight heparin calcium 4100 AXaIU/time. by abdominal subcutaneous injection once every 12 h. For both groups, one treatment course lasted 10 days. The pulmonary function indicators and blood coagulation indicators of the two groups before and after treatment were determined. Following treatment, the pulmonary function and arterial blood gas indicators of the two groups were significantly better than those before treatment, and the extents of the improvements in the anticoagulation group were significantly greater than those in the control group. The D-dimer level and blood coagulation indicators [international normalized ratio (INR), prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) concentration] of the anticoagulation group were significantly improved compared with those prior to treatment, but there were no significant differences between these measures before and after treatment for patients in the control group. No serious adverse reaction occurred in the anticoagulation group. Although, the conventional therapy was able to improve the overall condition of patients with COPD, it was not able to effectively improve the hypercoagulative state of the patients' blood. The combination of conventional therapy with low-molecular-weight heparin calcium anticoagulation improved the blood coagulation and pulmonary functions of patients.
View Figures
View References

1. 

Hu XY, Li Y, Du YC and Xu JY: Prethrombolic state and efficacy of anticoagulation of patients with acute exacerbations of chronic obstructive pulmonary disease. International Journal of Respiration. 29:519–522. 2009.(In Chinese).

2. 

Jiang ZH, Lv YW, Sang HY, Zhu MY, Zhu ZP and Ding P: The study of prethrombotic state in patients with chronic respiratory failure study. Chinese Journal of Emergency Medicine. 16:75–77. 2007.(In Chinese).

3. 

Huang J, Liu XJ and Bao HR: Chronic obstructive pulmonary disease in patients with coagulation dysfunction and oxidative stress in the relationship between. J Int Med. 50:82011.(In Chinese).

4. 

Huang J, Liu XJ, Bao HR, Zhang Y, Tan EL and Liao JM: The relationship between coagulation/anticoagulation imbalance and oxidative stress in patients with chronic obstructive pulmonary disease. Zhonghua Nei Ke Za Zhi. 50:664–667. 2011.(In Chinese).

5. 

Wang PF and Ling CH: Correlation study of patients with chronic obstructive pulmonary disease (COPD) arterial blood gas analysis and plasma D-dimer. Hemorheol. 20:87–88. 2010.(In Chinese).

6. 

Chronic Obstructive Pulmonary Disease Committee, Respiratory Society, Chinese Medical Association: Improved confidence, right awareness and rational treatment: opening up a new era of prevention and treatment of chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi. 30:3–5. 2007.(In Chinese).

7. 

Zarfis JH: Atherosclerosis thrombosis and inflammatory risk factors from history and the laboratory to real life. Eur Heart J. 26:317–318. 2005. View Article : Google Scholar : PubMed/NCBI

8. 

Ye XF, Liu S and Yang JH: Pulmonary heart disease in patients with D-dimer levels and systolic pulmonary artery pressure and carbon dioxide partial pressure correlation analysis. Cardiopulmonary Vascular J. 27:89–91. 2008.(In Chinese).

9. 

Yu CN, Sun L and Jiang P: Patients with pulmonary heart disease coagulation and fibrinolysis state. Zhonghua Jian Yan Yi Xue Za Zhi. 4:320–321. 2008.(In Chinese).

10. 

Duan JM, An X, Zhang JY, Xu F and Liu P: Chronic obstructive pulmonary disease (COPD) patients with hypoxemia clinical D-dimer testing and clinical analysis. Journal of Clinical Pulmonary Medicine. 13:199–200. 2008.(In Chinese).

11. 

Wu WN, Wang LX and Chen SX: Patients with chronic obstructive pulmonary disease (COPD) erythrocyte sedimentation rate, hematocrit, D-dimer, pulmonary artery systolic pressure. Practical J Med. 25:19–20. 2009.(In Chinese).

12. 

Dahl M, Tybjaerg-Hansen A, Vestbo J, Lange P and Nordestgaard BG: Elevated plasma fibrinogen associated with reduced pulmonary function and increased risk of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 164:1008–1011. 2001. View Article : Google Scholar : PubMed/NCBI

13. 

Wu TP: Significance in patients with chronic obstructive pulmonary disease D-dimer. Chin Med. 2:50–51. 2007.(In Chinese).

14. 

Yu QH and Li YC: Chronic obstructive pulmonary disease in patients with D-dimer and antithrombin relationship with prognosis. Tianjin Traditional Chin Med. 38:389–391. 2010.(In Chinese).

15. 

Mo FP: Chronic obstructive pulmonary disease with acute exacerbation of plasma D-dimer changes and the impact on the lung function of Guangxi Medical University, Department of Respiratory Medicine, 2011 (In Chinese).

16. 

Wu ZX, Zhang CF, Wang W, Li ZQ, Wang BF and Xu H: Therapeutic Effect of LMWH for Acute Exacerbation Patients of Pulmonary Heart Disease. China Health Industry. 8:5–6. 2011.(In Chinese).

17. 

Zhang Y, Li YX, Cao Y, Chai YL and Niu XQ: Unfractionated heparin and low-molecular-weight heparin in AECOPD pulmonary embolism in clinical observation. Journal of Kunming Medical University. 6:82–84. 2012.(In Chinese).

18. 

Segal JB, Streiff MB, Hofmann LV, Thornton K and Bass EB: Management of venous thromboembolism: a systematic review for a practice guideline. Ann Intern Med. 146:211–222. 2007. View Article : Google Scholar : PubMed/NCBI

19. 

Chen LY, Ying KJ, Hong WJ and Zhou P: Comparison of low-molecular-weight-heparin and unfractionated heparin for acute PTE. J Zhejiang Univ Sci B. 6:1195–1199. 2005. View Article : Google Scholar : PubMed/NCBI

20. 

Wang R and Peng HX: Low-molecular-weight heparin and heparin sodium efficacy for the treatment of pulmonary heart disease with comparison - report of 40 cases. New Med. 39:36–37. 48:2008.

21. 

Qiu XY and Jin N: Anticoagulant treatment of severe chronic obstructive pulmonary disease oxygenation function and central venous pressure impact. Chin Modern Sci Magazine. 5:231–232. 2008.(In Chinese).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shi X and Li H: Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage. Exp Ther Med 5: 1367-1370, 2013.
APA
Shi, X., & Li, H. (2013). Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage. Experimental and Therapeutic Medicine, 5, 1367-1370. https://doi.org/10.3892/etm.2013.1001
MLA
Shi, X., Li, H."Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage". Experimental and Therapeutic Medicine 5.5 (2013): 1367-1370.
Chicago
Shi, X., Li, H."Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1367-1370. https://doi.org/10.3892/etm.2013.1001
Copy and paste a formatted citation
x
Spandidos Publications style
Shi X and Li H: Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage. Exp Ther Med 5: 1367-1370, 2013.
APA
Shi, X., & Li, H. (2013). Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage. Experimental and Therapeutic Medicine, 5, 1367-1370. https://doi.org/10.3892/etm.2013.1001
MLA
Shi, X., Li, H."Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage". Experimental and Therapeutic Medicine 5.5 (2013): 1367-1370.
Chicago
Shi, X., Li, H."Anticoagulation therapy in patients with chronic obstructive pulmonary disease in the acute exacerbation stage". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1367-1370. https://doi.org/10.3892/etm.2013.1001
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team