The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease

Zhang,Qianlin; Du,Xiaoping; Xu,Yuping; Dang,Lei; Xiang,Li; Zhang,Jiewen

doi:10.3892/etm.2013.1006

The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease

Authors:
- Qianlin Zhang
- Xiaoping Du
- Yuping Xu
- Lei Dang
- Li Xiang
- Jiewen Zhang
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Affiliations: Department of Neurology, Renmin's Hospital, Zhengzhou, Henan 450006, P.R. China, Department of Neurology, Xiangya Hospital, Changsha, Hunan 450008, P.R. China
Published online on: March 14, 2013 https://doi.org/10.3892/etm.2013.1006
Pages: 1528-1530

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Abstract

The present study examined the effects of Gouqi (Lycium barbarum) on the learning and memory abilities of an APP/PS1 double transgenic mouse model of Alzheimer's disease. We employed a Morris water maze to examine the spatial memory in this mice line with or without Gouqi extracts treatment. We identified that 2 weeks of oral administration of Gouqi extracts at 10 mg/kg improved the performance of the APP/PS1 mice in the learning and the memory retrieval phases of the Morris maze. In correlation with this, the levels of Aβ(1-42) in hippocampal tissue were reduced by the Gouqi treatment. We conclude that pharmacological treatment with Gouqi extracts is beneficial at the later stages of Alzheimer's disease.

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1.	Chang RC and So KF: Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? Cell Mol Neurobiol. 28:643–652. 2008.PubMed/NCBI
2.	Liu H, Fan Y, Wang W, Liu N, Zhang H, Zhu Z, et al: Polysaccharides from Lycium barbarum leaves: isolation, characterization and splenocyte proliferation activity. Int J Biol Macromol. 51:417–422. 2012.
3.	Luo Q, Cai Y, Yan J, Sun M and Corke H: Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci. 76:137–149. 2004. View Article : Google Scholar : PubMed/NCBI
4.	Xiao J, Liong EC, Ching YP, Chang RC, So KF, et al: Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. J Ethnopharmacol. 139:462–470. 2012. View Article : Google Scholar
5.	Cheng D and Kong H: The effect of Lycium barbarum polysaccharide on alcohol-induced oxidative stress in rats. Molecules. 16:2542–2550. 2011.
6.	Li SY, Yang D, Yeung CM, Yu WY, Chang RC, So KF, et al: Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS One. 6:e163802011. View Article : Google Scholar
7.	Wu PS, Wu SJ, Tsai YH, Lin YH and Chao JC: Hot water extracted Lycium barbarum and Rehmannia glutinosa inhibit liver inflammation and fibrosis in rats. Am J Chin Med. 39:1173–1191. 2011.
8.	Ling Y, Li S, Yang J, Yuan J and He C: Co-administration of the polysaccharide of Lycium barbarum with DNA vaccine of Chlamydophila abortus augments protection. Immunol Invest. 40:1–13. 2011.PubMed/NCBI
9.	Wang J, Hu Y, Wang D, Liu J, Zhang J, Abula S, et al: Sulfated modification can enhance the immune-enhancing activity of Lycium barbarum polysaccharides. Cell Immunol. 263:219–223. 2010. View Article : Google Scholar : PubMed/NCBI
10.	Yang D, Li SY, Yeung CM, Chang RC, So KF, Wong D, et al: Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke. PLoS One. 7:e335962012. View Article : Google Scholar
11.	Ho YS, Yu MS, Yik SY, So KF, Yuen WH and Chang RC: Polysaccharides from wolf berry antagonizes glutamate excitotoxicity in rat cortical neurons. Cell Mol Neurobiol. 29:1233–1244. 2009. View Article : Google Scholar : PubMed/NCBI
12.	Ho YS, Yu MS, Lai CS, So KF, Yuen WH and Chang RC: Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on beta-amyloid peptide neurotoxicity. Brain Res. 1158:123–134. 2007. View Article : Google Scholar : PubMed/NCBI
13.	Yu MS, Leung SK, Lai SW, Che CM, Zee SY, So KF, et al: Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against beta-amyloid peptide neurotoxicity. Exp Gerontol. 40:716–727. 2005. View Article : Google Scholar : PubMed/NCBI
14.	Lee MR, Yun BS, Park SY, Ly SY, Kim SN, Han BH, et al: Anti-amnesic effect of Chong-Myung-Tang on scopolamine-induced memory impairments in mice. J Ethnopharmacol. 132:70–74. 2010. View Article : Google Scholar : PubMed/NCBI
15.	Hoxha E, Boda E, Montarolo F, Parolisi R and Tempia F: Excitability and synaptic alterations in the cerebellum of APP/PS1 mice. PLoS One. 7:e347262012. View Article : Google Scholar : PubMed/NCBI
16.	Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, et al: Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiol Aging. 33:e23–e39. 2012. View Article : Google Scholar : PubMed/NCBI
17.	Park SM, Shin JH, Moon GJ, Cho SI, Lee YB and Gwag BJ: Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice. BMC Neurosci. 12:1062011. View Article : Google Scholar : PubMed/NCBI
18.	van Groen T, Kadish I, Funke A, Bartnik D and Willbold D: Treatment with Abeta42 binding D-amino acid peptides reduce amyloid deposition and inflammation in APP/PS1 double transgenic mice. Adv Protein Chem Struct Biol. 88:133–152. 2012.PubMed/NCBI
19.	Vidal K, Bucheli P, Gao Q, Moulin J, Shen LS, Wang J, et al: Immunomodulatory effects of dietary supplementation with a milk-based wolfberry formulation in healthy elderly: a randomized, double-blind, placebo-controlled trial. Rejuvenation Res. 15:89–97. 2012. View Article : Google Scholar
20.	Ho YS, Yu MS, Yang XF, So KF, Yuen WH and Chang RC: Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. J Alzheimers Dis. 19:813–827. 2010.PubMed/NCBI