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Article

Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass

  • Authors:
    • Zhiwei Zhang
    • Yuan Wu
    • Yuan Zhao
    • Xianzhong Xiao
    • Junwen Liu
    • Xinmin Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Pathophysiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, P.R. China
  • Pages: 1523-1527
    |
    Published online on: March 22, 2013
       https://doi.org/10.3892/etm.2013.1026
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Abstract

High mobility group box 1 (HMGB1), which is released by activated immune cells and necrotic cells, has properties similar to those of pro-inflammatory cytokines. Cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted to observe the dynamic changes of HMGB1 and tumor necrosis factor (TNF)-α levels during CPB and to analyze their clinical significance. A total of 78 cases of American Society of Anesthesiologists (ASA) grade II-IV undergoing elective valve replacement under CPB were included in this study. Blood and urine samples were collected after anesthesia prior to surgery (T1), before aortic cross-clamping (T2), after CPB (T3) and on the first day after surgery (T4), as well as the second (T5) and third (T6) day after surgery for determination of the levels of HMGB1, TNF-α, alanine aminotransferase (ALT), creatinine (Cr), blood urea nitrogen (BUN), N-acetyl-β-D-glucosamidase (NAG) and β2-microglobulin (β2-MG). Results revealed that: i) the serum levels of HMGB1 elevated as early as T1, increased until reaching a peak at T3, then decreased to a lower level at T4; ii) the serum level of TNF-α was low at T1, gradually increased in a similar manner to HMGB1, then decreased following CPB and reached the lowest point at T5; and iii) the levels of HMGB1 were positively correlated with serum TNF-α and serum ALT at T3. In conclusion, HMGB1 levels may be used as an indicator of inflammation and may be a novel target for controlling inflammation during CPB. The optimal treatment time is T3 (after CPB).
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Wu Y, Zhao Y, Xiao X, Liu J and Zhou X: Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass. Exp Ther Med 5: 1523-1527, 2013.
APA
Zhang, Z., Wu, Y., Zhao, Y., Xiao, X., Liu, J., & Zhou, X. (2013). Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass. Experimental and Therapeutic Medicine, 5, 1523-1527. https://doi.org/10.3892/etm.2013.1026
MLA
Zhang, Z., Wu, Y., Zhao, Y., Xiao, X., Liu, J., Zhou, X."Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass". Experimental and Therapeutic Medicine 5.5 (2013): 1523-1527.
Chicago
Zhang, Z., Wu, Y., Zhao, Y., Xiao, X., Liu, J., Zhou, X."Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1523-1527. https://doi.org/10.3892/etm.2013.1026
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Wu Y, Zhao Y, Xiao X, Liu J and Zhou X: Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass. Exp Ther Med 5: 1523-1527, 2013.
APA
Zhang, Z., Wu, Y., Zhao, Y., Xiao, X., Liu, J., & Zhou, X. (2013). Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass. Experimental and Therapeutic Medicine, 5, 1523-1527. https://doi.org/10.3892/etm.2013.1026
MLA
Zhang, Z., Wu, Y., Zhao, Y., Xiao, X., Liu, J., Zhou, X."Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass". Experimental and Therapeutic Medicine 5.5 (2013): 1523-1527.
Chicago
Zhang, Z., Wu, Y., Zhao, Y., Xiao, X., Liu, J., Zhou, X."Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1523-1527. https://doi.org/10.3892/etm.2013.1026
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