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Article

Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm

  • Authors:
    • Noritaka Wakui
    • Ryuji Takayama
    • Naohisa Kamiyama
    • Kojiro Kobayashi
    • Daigo Matsui
    • Yasushi Matsukiyo
    • Takenori Kanekawa
    • Takashi Ikehara
    • Koji Ishii
    • Yasukiyo Sumino
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo 143-8541, Japan, Ultrasound General Imaging, GE Healthcare, Tokyo 191-8503, Japan
  • Pages: 1551-1554
    |
    Published online on: April 4, 2013
       https://doi.org/10.3892/etm.2013.1048
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Abstract

It is considered difficult to make a definitive diagnosis of focal nodular hyperplasia (FNH) of <3 cm when using conventional diagnostic imaging modalities. Typical FNH imaging findings are: i) central scar formation, ii) nutrient vessels extending radially from the center and iii) the presence of Kupffer cells. In a clinical setting, identification of a spoke-wheel pattern formed by nutrient vessels extending radially is a key feature in the diagnosis of FNH. In this study, we investigated the detection rate of spoke-wheel patterns of FNH <3 cm using arrival time parametric imaging (At-PI) technology with Sonazoid-enhanced ultrasonography (US). Five patients with FNH <3 cm who had undergone Sonazoid‑enhanced US at the Toho University Omori Medical Center between February 2008 and March 2009 were included in the study. The mean tumor diameter was 20.2±7.2 mm. Lesions were enhanced with 0.5 ml Sonazoid US contrast agent and a video of the procedure was saved and used for At-PI analysis of contrast agent dynamics in FNH. Three ultrasonographic specialists examined the images and made a diagnosis of FNH based on the findings of spoke-wheel patterns. Similarly, micro-flow imaging (MFI) was performed to evaluate the contrast agent dynamics in FNH. Using MFI, FNH was diagnosed in 3 of the 5 cases by the three specialists, whereas At-PI enabled the identification of spoke-wheel patterns in all 5 cases. At-PI using Sonazoid-enhanced US is superior for detecting spoke-wheel patterns of FNH <3 cm.
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Copy and paste a formatted citation
Spandidos Publications style
Wakui N, Takayama R, Kamiyama N, Kobayashi K, Matsui D, Matsukiyo Y, Kanekawa T, Ikehara T, Ishii K, Sumino Y, Sumino Y, et al: Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm. Exp Ther Med 5: 1551-1554, 2013.
APA
Wakui, N., Takayama, R., Kamiyama, N., Kobayashi, K., Matsui, D., Matsukiyo, Y. ... Sumino, Y. (2013). Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm. Experimental and Therapeutic Medicine, 5, 1551-1554. https://doi.org/10.3892/etm.2013.1048
MLA
Wakui, N., Takayama, R., Kamiyama, N., Kobayashi, K., Matsui, D., Matsukiyo, Y., Kanekawa, T., Ikehara, T., Ishii, K., Sumino, Y."Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm". Experimental and Therapeutic Medicine 5.6 (2013): 1551-1554.
Chicago
Wakui, N., Takayama, R., Kamiyama, N., Kobayashi, K., Matsui, D., Matsukiyo, Y., Kanekawa, T., Ikehara, T., Ishii, K., Sumino, Y."Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm". Experimental and Therapeutic Medicine 5, no. 6 (2013): 1551-1554. https://doi.org/10.3892/etm.2013.1048
Copy and paste a formatted citation
x
Spandidos Publications style
Wakui N, Takayama R, Kamiyama N, Kobayashi K, Matsui D, Matsukiyo Y, Kanekawa T, Ikehara T, Ishii K, Sumino Y, Sumino Y, et al: Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm. Exp Ther Med 5: 1551-1554, 2013.
APA
Wakui, N., Takayama, R., Kamiyama, N., Kobayashi, K., Matsui, D., Matsukiyo, Y. ... Sumino, Y. (2013). Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm. Experimental and Therapeutic Medicine, 5, 1551-1554. https://doi.org/10.3892/etm.2013.1048
MLA
Wakui, N., Takayama, R., Kamiyama, N., Kobayashi, K., Matsui, D., Matsukiyo, Y., Kanekawa, T., Ikehara, T., Ishii, K., Sumino, Y."Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm". Experimental and Therapeutic Medicine 5.6 (2013): 1551-1554.
Chicago
Wakui, N., Takayama, R., Kamiyama, N., Kobayashi, K., Matsui, D., Matsukiyo, Y., Kanekawa, T., Ikehara, T., Ishii, K., Sumino, Y."Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm". Experimental and Therapeutic Medicine 5, no. 6 (2013): 1551-1554. https://doi.org/10.3892/etm.2013.1048
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