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Gender-dependent miR-375 promoter methylation and the risk of type 2 diabetes

  • Authors:
    • Jia Cheng
    • Lingyan Wang
    • Leiting Xu
    • Hongwei Wang
    • Panpan Liu
    • Shizhong Bu
    • Meng Ye
    • Lina Zhang
    • Qinwen Wang
    • Shiwei Duan

  • View Affiliations

  • Published online on: April 18, 2013     https://doi.org/10.3892/etm.2013.1069
  • Pages: 1687-1692
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Abstract

Promoter DNA methylation may reflect the interaction between genetic background and environmental factors in the development of metabolic disorders, including type 2 diabetes (T2D). As an epigenetic factor of T2D, miR-375 plays an important role in the functional accommodation of islet cells. In the present study, we investigated the association of promoter DNA methylation of the miR-375 gene with the risk of T2D. Using bisulfite pyrosequencing technology, the DNA methylation levels of eight CpG dinucleotides on the miR-375 promoter were measured in 48 T2D cases and 48 healthy controls. The majority of CpGs (with the exception of CpG7) had significantly higher methylation levels in women compared with those in men (P<0.05). The methylation levels of the eight CpGs were significantly correlated with each other (P<0.001). No significant association between miR-375 gene promoter methylation and the risk of T2D was identified (P=0.417). Similar results were observed in the breakdown analysis by gender (men, P=0.844; women, P=0.234). In addition, although a correlation between the CpG8 methylation level of miR-375 and total triglyceride level was identified in women (P=0.009), DNA methylation of the majority of CpGs in the miR-375 gene promoter was not associated with the clinical metabolic features of the individuals.
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June 2013
Volume 5 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cheng J, Wang L, Xu L, Wang H, Liu P, Bu S, Ye M, Zhang L, Wang Q, Duan S, Duan S, et al: Gender-dependent miR-375 promoter methylation and the risk of type 2 diabetes. Exp Ther Med 5: 1687-1692, 2013
APA
Cheng, J., Wang, L., Xu, L., Wang, H., Liu, P., Bu, S. ... Duan, S. (2013). Gender-dependent miR-375 promoter methylation and the risk of type 2 diabetes. Experimental and Therapeutic Medicine, 5, 1687-1692. https://doi.org/10.3892/etm.2013.1069
MLA
Cheng, J., Wang, L., Xu, L., Wang, H., Liu, P., Bu, S., Ye, M., Zhang, L., Wang, Q., Duan, S."Gender-dependent miR-375 promoter methylation and the risk of type 2 diabetes". Experimental and Therapeutic Medicine 5.6 (2013): 1687-1692.
Chicago
Cheng, J., Wang, L., Xu, L., Wang, H., Liu, P., Bu, S., Ye, M., Zhang, L., Wang, Q., Duan, S."Gender-dependent miR-375 promoter methylation and the risk of type 2 diabetes". Experimental and Therapeutic Medicine 5, no. 6 (2013): 1687-1692. https://doi.org/10.3892/etm.2013.1069