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Article

Application of acellular dermal xenografts in full-thickness skin burns

  • Authors:
    • Xiaodong Chen
    • Xiangsheng Feng
    • Julin Xie
    • Shubin Ruan
    • Yan Lin
    • Zepeng Lin
    • Rui Shen
    • Fenggang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Burns Surgery, The First People's Hospital of Foshan, Foshan, Guangdong 528000, P.R. China, Department of Burns Surgery, The First Affiliated Hospital of Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 194-198
    |
    Published online on: May 15, 2013
       https://doi.org/10.3892/etm.2013.1114
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Abstract

The aim of this study was to explore the clinical value of the porcine acellular dermal xenograft (ADX) in combination with autologous split-thickness skin and pure autologous split-thickness skin grafting applied in deep full-thickness burns and scar wounds. A total of 30 patients with deep burns were randomly divided into experimental and control groups following escharectomy. The patients were separately treated with porcine acellular dermal xenograft (ADX) in combination with autologous split-thickness skin and pure autologous split-thickness skin graft. The wound healing was observed routinely and the scores were evaluated using Vancouver scar scale at different times following transplant surgery. The samples of cograft regions and the control group (pure transplant split-thickness skin autograft) were observed using light microscopy and electron microscopy, and the follow-up results were recorded. No conspicuous rejections on the cograft wound surface were observed. Compared with the control group, the cograft wounds were smooth, presented no scar contracture and exhibited good skin elasticity and recovery of the joint function. The cografted skin combined well and displayed a clear and continuous basal membrane, as well as gradually combined skin structure, a mature stratum corneum, downward extended rete pegs, a mainly uniform dermal collagen fiber structure, regular alignment, and fewer blood capillaries. Clear desmosome cograft regions were identified among heckle cells, as well as a clear and continuous basal membrane. The cografted skin of the combined split-thickness autograft and the acellular heterologous (porcine) dermal matrix showed an improved shape and functional recovery compared with the pure split-thickness skin autograft. The combination of the meshed ADX and the split-thickness skin autograft applied in deep full-thickness burns and scar wounds may induce tissue regeneration via dermis aiming. This method also has superior shape and functional recovery, and has an extensive clinical application value.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Feng X, Xie J, Ruan S, Lin Y, Lin Z, Shen R and Zhang F: Application of acellular dermal xenografts in full-thickness skin burns. Exp Ther Med 6: 194-198, 2013.
APA
Chen, X., Feng, X., Xie, J., Ruan, S., Lin, Y., Lin, Z. ... Zhang, F. (2013). Application of acellular dermal xenografts in full-thickness skin burns. Experimental and Therapeutic Medicine, 6, 194-198. https://doi.org/10.3892/etm.2013.1114
MLA
Chen, X., Feng, X., Xie, J., Ruan, S., Lin, Y., Lin, Z., Shen, R., Zhang, F."Application of acellular dermal xenografts in full-thickness skin burns". Experimental and Therapeutic Medicine 6.1 (2013): 194-198.
Chicago
Chen, X., Feng, X., Xie, J., Ruan, S., Lin, Y., Lin, Z., Shen, R., Zhang, F."Application of acellular dermal xenografts in full-thickness skin burns". Experimental and Therapeutic Medicine 6, no. 1 (2013): 194-198. https://doi.org/10.3892/etm.2013.1114
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Feng X, Xie J, Ruan S, Lin Y, Lin Z, Shen R and Zhang F: Application of acellular dermal xenografts in full-thickness skin burns. Exp Ther Med 6: 194-198, 2013.
APA
Chen, X., Feng, X., Xie, J., Ruan, S., Lin, Y., Lin, Z. ... Zhang, F. (2013). Application of acellular dermal xenografts in full-thickness skin burns. Experimental and Therapeutic Medicine, 6, 194-198. https://doi.org/10.3892/etm.2013.1114
MLA
Chen, X., Feng, X., Xie, J., Ruan, S., Lin, Y., Lin, Z., Shen, R., Zhang, F."Application of acellular dermal xenografts in full-thickness skin burns". Experimental and Therapeutic Medicine 6.1 (2013): 194-198.
Chicago
Chen, X., Feng, X., Xie, J., Ruan, S., Lin, Y., Lin, Z., Shen, R., Zhang, F."Application of acellular dermal xenografts in full-thickness skin burns". Experimental and Therapeutic Medicine 6, no. 1 (2013): 194-198. https://doi.org/10.3892/etm.2013.1114
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