Comparison of optic nerve morphology in eyes with glaucoma and eyes with non-arteritic anterior ischemic optic neuropathy by Fourier domain optical coherence tomography

Yang,Yuxin; Zhang,Haitao; Yan,Yitao; Gui,Yanling; Zhu,Tiechui

doi:10.3892/etm.2013.1115

July 2013 Volume 6 Issue 1

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July 2013 Volume 6 Issue 1

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Article

Comparison of optic nerve morphology in eyes with glaucoma and eyes with non-arteritic anterior ischemic optic neuropathy by Fourier domain optical coherence tomography

Authors:
- Yuxin Yang
- Haitao Zhang
- Yitao Yan
- Yanling Gui
- Tiechui Zhu
View Affiliations / Copyright

Affiliations: Department of Ophthalmology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China, Department of Nursing, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China, Department of Nephrology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China
Pages: 268-274
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Published online on: May 15, 2013

https://doi.org/10.3892/etm.2013.1115
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Abstract

The aim of this study was to compare the optic nerve head (ONH) and peripapillary retinal nerve fiber layer (RNFL) thickness in eyes with glaucoma and non-arteritic anterior ischemic neuropathy (NAION) by Fourier domain optical coherence tomography (FDOCT), and to evaluate the diagnostic capability of FDOCT in glaucoma and NAION. This study included 26 eyes with glaucoma (36.6%), 15 eyes with NAION (21.1%) and 30 eyes of normal subjects (42.3%). Those with the following conditions were excluded; a visual field defect greater than one hemifield, spherical equivalent (SE) more than ±6 D, or the onset of NAION within 6 months. FDOCT was used to analyze the characteristics of ONH and RNFL thickness. Among the three groups of subjects, glaucomatous eyes had the largest cup area and cup volume, and the smallest rim area, rim volume and disc volume (P<0.05). NAION eyes had the smallest cup area and cup volume (P<0.05), but their rim area, rim volume and disc volume were comparable to those of control eyes (P>0.05). The cup-to-disc (C/D) ratio was increased in glaucomatous eyes but reduced in NAION eyes compared with control eyes. Glaucomatous eyes had the greatest loss of RNFL thickness in the temporal upper (TU), superior temporal (ST) and temporal lower (TL) regions (P<0.05), whereas NAION eyes had the smallest RNFL thickness in the superior nasal (SN) and nasal upper (NU) regions (P<0.05). The areas under the receiver operator characteristic curve (AROCs) of the temporal, superior and inferior RNFL in glaucomatous eyes were greater compared with that of the disc area (P<0.05). In addition, the AROCs of the temporal, superior and inferior RNFL were higher compared with that of nasal RNFL (P<0.05). The AROCs of all parameters for NAION were not significantly different, with the exception of superior, nasal superior and inferior temporal RNFL (P<0.05). In conclusion, FDOCT is able to detect quantitative differences in the optic disc morphology and RNFL thickness between glaucomatous and NAION eyes. These differences may provide new insights into the clinical characteristics and diagnosis of the two diseases.

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1.	Pasol J: Neuro-ophthalmic disease and optical coherence tomography: glaucoma look-alikes. Curr Opin Ophthalmol. 22:124–132. 2011. View Article : Google Scholar : PubMed/NCBI
2.	González-García AO, Vizzeri G, Bowd C, Medeiros FA, Zangwill LM and Weinreb RN: Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements. Am J Ophthalmol. 147:1067–1074. 2009.PubMed/NCBI
3.	Garas A, Kóthy P and Holló G: Accuracy of the RTVue-100 Fourier-domain optical coherence tomograph in an optic neuropathy screening trial. Int Ophthalmol. 31:175–182. 2011. View Article : Google Scholar : PubMed/NCBI
4.	Saito H, Tomidokoro A, Sugimoto E, et al: Optic disc topography and peripapillary retinal nerve fiber layer thickness in nonarteritic ischemic optic neuropathy and open-angle glaucoma. Ophthalmology. 113:1340–1344. 2006. View Article : Google Scholar : PubMed/NCBI
5.	Danesh-Meyer H, Savino PJ, Spaeth GL and Gamble GD: Comparison of arteritis and nonarteritic anterior ischemic optic neuropathies with the Heidelberg Retina Tomograph. Ophthalmology. 112:1104–1112. 2005. View Article : Google Scholar
6.	Chan CK, Cheng AC, Leung CK, Cheung CY, Yung AY, Gong B and Lam DS: Quantitative assessment of optic nerve head morphology and retinal nerve fibre layer in non-arteritic anterior ischaemic optic neuropathy with optical coherence tomography and confocal scanning laser ophthalmoloscopy. Br J Ophthalmol. 93:731–735. 2009. View Article : Google Scholar
7.	Danesh-Meyer HV, Boland MV, Savino PJ, Miller NR, Subramanian PS, Girkin CA and Quigley HA: Optic disc morphology in open-angle glaucoma compared with anterior ischemic optic neuropathies. Invest Ophthalmol Vis Sci. 51:2003–2010. 2010. View Article : Google Scholar
8.	Horowitz J, Fishelzon-Arev T, Rath EZ, Segev E and Geyer O: Comparison of optic nerve head topography findings in eyes with non-arteritic anterior ischemic optic neuropathy and eyes with glaucoma. Graefes Arch Clin Exp Ophthalmol. 248:845–851. 2010. View Article : Google Scholar : PubMed/NCBI
9.	Suh MH, Kim SH, Park KH, Kim SJ, Kim TW, Hwang SS and Kim DM: Comparison of the correlations between optic disc rim area and retinal nerve fiber layer thickness in glaucoma and nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 151:277–286. 2011. View Article : Google Scholar : PubMed/NCBI
10.	Contreras I, Noval S, Rebolleda G and Muñoz-Negrete FJ: Follow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography. Ophthalmology. 114:2338–2344. 2007. View Article : Google Scholar : PubMed/NCBI
11.	Contreras I, Rebolleda G, Noval S and Muñoz-Negrete FJ: Optic disc evaluation by optical coherence tomography in nonarteritic anterior ischemic optic neuropathy. Invest Ophthalmol Vis Sci. 48:4087–4092. 2007. View Article : Google Scholar : PubMed/NCBI
12.	Hood DC, Anderson S, Rouleau J, et al: Retinal nerve fiber structure versus visual field function in patients with ischemic optic neuropathy. A test of a linear model. Ophthalmology. 115:904–910. 2008. View Article : Google Scholar : PubMed/NCBI
13.	Leung CK, Cheung CY, Weinreb RN, et al: Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study. Ophthalmology. 116:1257–1263. 2009. View Article : Google Scholar : PubMed/NCBI
14.	Lisboa R, Leite MT, Zangwill LM, Tafreshi A, Weinreb RN and Medeiros FA: Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography. Ophthalmology. 119:2261–2269. 2012. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Comparison of optic nerve morphology in eyes with glaucoma and eyes with non-arteritic anterior ischemic optic neuropathy by Fourier domain optical coherence tomography

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Abstract

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