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Article

Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field

  • Authors:
    • Sibel Köktürk
    • Melda Yardimoglu
    • Saadet D. Celikozlu
    • Elif Gelenli Dolanbay
    • Ali Cimbiz
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Faculty of Medicine, Ordu University, Ordu 52200, Turkey, Department of Histology and Embryology, Faculty of Medicine, Kocaeli University, Kocaeli 41380, Turkey, Altıntaş Vocational School of Dumlupinar University, Altıntaş, Kütahya 43800, Turkey, Department of Physical Therapy and Rehabilitation, Faculty of Health Sciences, Zirve University, Gaziantep 27260, Turkey
  • Pages: 52-56
    |
    Published online on: May 17, 2013
       https://doi.org/10.3892/etm.2013.1123
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Abstract

The expansion of mobile phone technology has raised concerns regarding the effect of 900‑MHz electromagnetic field (EMF) exposure on the central nervous system. At present, the developing human brain is regularly exposed to mobile telephones, pre‑ and postnatally. Several studies have demonstrated the acute effects of EMF exposure during pre‑ or postnatal periods; however, the chronic effects of EMF exposure are less understood. Thus, the aim of the present study was to determine the chronic effects of EMF on the pre‑ and postnatal rat cerebellum. The control group was maintained in the same conditions as the experimental groups, without the exposure to EMF. In the EMF1 group, the rats were exposed to EMF during pre‑ and postnatal periods (until postnatal day 80). In the EMF2 group, the rats were also exposed to EMF pre‑ and postnatally; in addition, however, they were provided with a daily oral supplementation of Lycopersicon esculentum extract (~2 g/kg). The number of caspase‑3‑labeled Purkinje neurons and granule cells present in the rats in the control and experimental groups were then counted. The neurodegenerative changes were studied using cresyl violet staining, and these changes were evaluated. In comparison with the control animals, the EMF1 group demonstrated a significant increase in the number of caspase‑3‑labeled Purkinje neurons and granule cells present in the cerebellum (P<0.001). However, in comparison with the EMF1 group, the EMF2 group exhibited significantly fewer caspase‑3‑labeled Purkinje neurons and granule cells in the cerebellum. In the EMF1 group, the Purkinje neurons were revealed to have undergone dark neuron degenerative changes. However, the presence of dark Purkinje neurons was reduced in the EMF2 group, compared with the EMF1 group. The results indicated that apoptosis and neurodegeneration in rats exposed to EMF during pre‑ and postnatal periods may be reduced with Lycopersicon esculentum extract therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Köktürk S, Yardimoglu M, Celikozlu SD, Dolanbay EG and Cimbiz A: Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field. Exp Ther Med 6: 52-56, 2013.
APA
Köktürk, S., Yardimoglu, M., Celikozlu, S.D., Dolanbay, E.G., & Cimbiz, A. (2013). Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field. Experimental and Therapeutic Medicine, 6, 52-56. https://doi.org/10.3892/etm.2013.1123
MLA
Köktürk, S., Yardimoglu, M., Celikozlu, S. D., Dolanbay, E. G., Cimbiz, A."Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field". Experimental and Therapeutic Medicine 6.1 (2013): 52-56.
Chicago
Köktürk, S., Yardimoglu, M., Celikozlu, S. D., Dolanbay, E. G., Cimbiz, A."Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field". Experimental and Therapeutic Medicine 6, no. 1 (2013): 52-56. https://doi.org/10.3892/etm.2013.1123
Copy and paste a formatted citation
x
Spandidos Publications style
Köktürk S, Yardimoglu M, Celikozlu SD, Dolanbay EG and Cimbiz A: Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field. Exp Ther Med 6: 52-56, 2013.
APA
Köktürk, S., Yardimoglu, M., Celikozlu, S.D., Dolanbay, E.G., & Cimbiz, A. (2013). Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field. Experimental and Therapeutic Medicine, 6, 52-56. https://doi.org/10.3892/etm.2013.1123
MLA
Köktürk, S., Yardimoglu, M., Celikozlu, S. D., Dolanbay, E. G., Cimbiz, A."Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field". Experimental and Therapeutic Medicine 6.1 (2013): 52-56.
Chicago
Köktürk, S., Yardimoglu, M., Celikozlu, S. D., Dolanbay, E. G., Cimbiz, A."Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field". Experimental and Therapeutic Medicine 6, no. 1 (2013): 52-56. https://doi.org/10.3892/etm.2013.1123
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