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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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August 2013 Volume 6 Issue 2

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Article

Splenic siderotic nodules in patients with liver cirrhosis

  • Authors:
    • Huang‑Qing Ouyang
    • Zuo‑Jiong Gong
    • Yun‑Fei Zha
    • Chang‑Sheng Liu
    • Zhao‑Hui Yang
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 445-450
    |
    Published online on: May 31, 2013
       https://doi.org/10.3892/etm.2013.1135
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Abstract

The aim of this study was to investigate the interrelation between splenic siderotic nodules, hypersplenism and liver function in patients with liver cirrhosis. The splenic enhanced susceptibility‑weighted angiography (ESWAN) and conventional magnetic resonance images of 33 patients with liver cirrhosis were retrospectively studied and the ESWAN images were graded. The distribution and prevalence of the image grades for patients with and without hypersplenism were evaluated. In addition, the splenic volume and the distribution of Child‑Pugh and albumin scores were compared between patients with and without siderotic nodules, and the correlation between splenic volume and the ESWAN image grades were evaluated in the patients with siderotic nodules. The ESWAN images revealed splenic siderotic nodules in 24 patients. The distribution and prevalence of the ESWAN image grades were demonstrated to be significantly different (P<0.001) between patients with and without hypersplenism. Furthermore, significant differences were observed between patients with and without siderotic nodules with regard to splenic volume and the distribution of Child‑Pugh and serum albumin scores (P<0.001). No significant correlation was demonstrated between splenic volume and the ESWAN image grades (P>0.05). In conclusion, a higher prevalence of splenic siderotic nodules (72.7%) was observed using the ESWAN sequence, in comparison with results from previous studies, obtained using the T1‑spoiled gradient echo sequence. The presence of splenic siderotic nodules was consistent with the occurrence of hypersplenism and was interrelated with reserved liver function.
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Copy and paste a formatted citation
Spandidos Publications style
Ouyang HQ, Gong ZJ, Zha YF, Liu CS and Yang ZH: Splenic siderotic nodules in patients with liver cirrhosis. Exp Ther Med 6: 445-450, 2013.
APA
Ouyang, H., Gong, Z., Zha, Y., Liu, C., & Yang, Z. (2013). Splenic siderotic nodules in patients with liver cirrhosis. Experimental and Therapeutic Medicine, 6, 445-450. https://doi.org/10.3892/etm.2013.1135
MLA
Ouyang, H., Gong, Z., Zha, Y., Liu, C., Yang, Z."Splenic siderotic nodules in patients with liver cirrhosis". Experimental and Therapeutic Medicine 6.2 (2013): 445-450.
Chicago
Ouyang, H., Gong, Z., Zha, Y., Liu, C., Yang, Z."Splenic siderotic nodules in patients with liver cirrhosis". Experimental and Therapeutic Medicine 6, no. 2 (2013): 445-450. https://doi.org/10.3892/etm.2013.1135
Copy and paste a formatted citation
x
Spandidos Publications style
Ouyang HQ, Gong ZJ, Zha YF, Liu CS and Yang ZH: Splenic siderotic nodules in patients with liver cirrhosis. Exp Ther Med 6: 445-450, 2013.
APA
Ouyang, H., Gong, Z., Zha, Y., Liu, C., & Yang, Z. (2013). Splenic siderotic nodules in patients with liver cirrhosis. Experimental and Therapeutic Medicine, 6, 445-450. https://doi.org/10.3892/etm.2013.1135
MLA
Ouyang, H., Gong, Z., Zha, Y., Liu, C., Yang, Z."Splenic siderotic nodules in patients with liver cirrhosis". Experimental and Therapeutic Medicine 6.2 (2013): 445-450.
Chicago
Ouyang, H., Gong, Z., Zha, Y., Liu, C., Yang, Z."Splenic siderotic nodules in patients with liver cirrhosis". Experimental and Therapeutic Medicine 6, no. 2 (2013): 445-450. https://doi.org/10.3892/etm.2013.1135
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