Comparison between absolute ethanol and bleomycin for the treatment of venous malformation in children

Zhang,Jing; Li,Hai-Bo; Zhou,Shao-Yi; Chen,Kun-Shan; Niu,Chuan-Qiang; Tan,Xiao-Yun; Jiang,Yi-Zhou; Lin,Que-Qing

doi:10.3892/etm.2013.1144

Comparison between absolute ethanol and bleomycin for the treatment of venous malformation in children

Authors:
- Jing Zhang
- Hai-Bo Li
- Shao-Yi Zhou
- Kun-Shan Chen
- Chuan-Qiang Niu
- Xiao-Yun Tan
- Yi-Zhou Jiang
- Que-Qing Lin
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Affiliations: Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou 510120, P.R. China
Published online on: June 5, 2013 https://doi.org/10.3892/etm.2013.1144
Pages: 305-309

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Abstract

The aim of this study was to investigate the therapeutic efficacies and treatment effects of absolute ethanol and bleomycin for the treatment of venous malformation (VM) in children. A total of 138 children with VM were randomly divided into two groups; 75 patients were treated with absolute ethanol, while a further 63 were treated with bleomycin under general anesthesia between February 2009 and February 2012. The treatment outcome and complications were observed in the two groups and the treatment efficacy was classified as one of four categories: cured, markedly effective, effective and ineffective. The curative effect was analyzed 6-24 months after treatment, with a mean of 15 months. Absolute ethanol was effective (cured, markedly effective or effective) in 71 cases and bleomycin was effective in 41 cases, and the difference between the effective rates was considered to be statistically significant (χ2=19.6, P<0.05). In the absolute ethanol group there were 14 cases with skin necrosis, 17 patients had serious localized swelling which required additional treatment, three patients developed muscle fibrosis and one patient suffered a brain embolism. In the bleomycin group there were five cases with skin necrosis and the difference in the incidence of adverse reactions was considered to be statistically significant (χ2=18.8, P<0.05). The curative effect of sclerotherapy for VM is clear, and absolute ethanol is the most effective sclerosing agent, but has a greater incidence of adverse side‑effects than bleomycin. The major side‑effect is skin necrosis. The choice of sclerotherapy depends on the classification of VM in children.

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