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Article

Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis

  • Authors:
    • Jing Shi
    • Jianhua Tong
    • Shuang Cai
    • Xiujuan Qu
    • Yunpeng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Drug Clinical Trials, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pharmacy, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 435-444
    |
    Published online on: June 7, 2013
       https://doi.org/10.3892/etm.2013.1148
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Abstract

Recent investigations have suggested that common genetic polymorphisms in BRCA1‑associated C‑terminal helicase 1 (BACH1) are important in the development of breast cancer. However, individually published studies and previous meta‑analyses have demonstrated inconclusive results. The aim of this meta‑analysis was to derive a more precise estimation of the correlation between a common polymorphism [proline (Pro) 919 serine (Ser); rs4986764 C>T] in the BACH1 gene and susceptibility to breast cancer. A literature search of PubMed, Embase, Web of Science and Chinese BioMedicine (CBM) databases was conducted on articles published prior to March 1, 2013. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Eleven case‑control studies were included with a total of 6,903 breast cancer cases and 8,154 healthy controls. The meta‑analysis results revealed that the BACH1 919Ser polymorphism may be correlated with a decreased risk of breast cancer among Caucasian populations (Ser allele versus Pro allele: OR=0.90, 95% CI=0.86‑0.95; Pro/Ser + Ser/Ser versus Pro/Pro: OR=0.90, 95% CI=0.84‑0.98; Ser/Ser versus Pro/Pro + Pro/Ser: OR=0.84, 95% CI=0.76‑0.92; Ser/Ser versus Pro/Pro: OR=0.81, 95% CI=0.73‑0.91; Ser/Ser versus Pro/Ser: OR=0.86, 95% CI=0.78‑0.95), although not among Asian populations. Further subgroup analyses indicated that there were significant correlations between the BACH1 919Ser polymorphism and a decreased risk of breast cancer in postmenopausal females, females with a family history of breast cancer and females without BRCA1/2 mutations. Univariate and multivariate meta‑regression analyses revealed that none of the factors explained the heterogeneity (all P>0.05). The present meta‑analysis suggested that the BACH1 919Ser polymorphism may decrease the risk of breast cancer among Caucasian populations, particularly in postmenopausal females with a family history of breast cancer and without BRCA1/2 mutations.
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Copy and paste a formatted citation
Spandidos Publications style
Shi J, Tong J, Cai S, Qu X and Liu Y: Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis. Exp Ther Med 6: 435-444, 2013.
APA
Shi, J., Tong, J., Cai, S., Qu, X., & Liu, Y. (2013). Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis. Experimental and Therapeutic Medicine, 6, 435-444. https://doi.org/10.3892/etm.2013.1148
MLA
Shi, J., Tong, J., Cai, S., Qu, X., Liu, Y."Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis". Experimental and Therapeutic Medicine 6.2 (2013): 435-444.
Chicago
Shi, J., Tong, J., Cai, S., Qu, X., Liu, Y."Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis". Experimental and Therapeutic Medicine 6, no. 2 (2013): 435-444. https://doi.org/10.3892/etm.2013.1148
Copy and paste a formatted citation
x
Spandidos Publications style
Shi J, Tong J, Cai S, Qu X and Liu Y: Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis. Exp Ther Med 6: 435-444, 2013.
APA
Shi, J., Tong, J., Cai, S., Qu, X., & Liu, Y. (2013). Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis. Experimental and Therapeutic Medicine, 6, 435-444. https://doi.org/10.3892/etm.2013.1148
MLA
Shi, J., Tong, J., Cai, S., Qu, X., Liu, Y."Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis". Experimental and Therapeutic Medicine 6.2 (2013): 435-444.
Chicago
Shi, J., Tong, J., Cai, S., Qu, X., Liu, Y."Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature‑based meta‑analysis and meta‑regression analysis". Experimental and Therapeutic Medicine 6, no. 2 (2013): 435-444. https://doi.org/10.3892/etm.2013.1148
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