A correlation analysis between the expression of pregnancy-associated plasma protein A in basal decidual cells and recurrent spontaneous abortion

  • Authors:
    • Ying Zhang
    • Qian Zhao
    • Ya Xie
    • Ke Su
    • Jun Yang
    • Li Yang
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  • Published online on: June 7, 2013     https://doi.org/10.3892/etm.2013.1149
  • Pages: 485-488
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Abstract

The aim of this study was to investigate the correlation between the expression of pregnancy-associated plasma protein A (PAPP-A) in basal decidual cells and recurrent spontaneous abortion (RSA). A total of 39 patients with a history of RSA were enrolled into the RSA group. A further 30 females who had experienced normal pregnancy were enrolled into the control group. The mRNA expression of PAPP-A in basal decidual cells was analyzed using real-time PCR. The distribution and expression of PAPP-A protein levels in basal decidual cells were analyzed by immunohistochemistry. The correlation between PAPP-A protein levels and RSA was analyzed. The levels of PAPP-A mRNA in the RSA group were significantly decreased, compared with the control group (P<0.05). Consistent with the mRNA levels, the protein levels of PAPP-A were also significantly lower in the RSA group compared with the control group (P<0.05). Multivariate logistic analysis indicated that the suppression of PAPP-A was one of the risk factors for RSA. Furthermore, Hosmer‑Lemeshow analysis suggested that the expression levels of PAPP-A is an important factor for predicting RSA. In conclusion, the expression levels of the PAPP-A protein were significantly reduced in basal decidual cells of the RSA group compared with the control group. Therefore, PAPP-A is likely to play an important role in RSA.
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August 2013
Volume 6 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang Y, Zhao Q, Xie Y, Su K, Yang J and Yang L: A correlation analysis between the expression of pregnancy-associated plasma protein A in basal decidual cells and recurrent spontaneous abortion. Exp Ther Med 6: 485-488, 2013
APA
Zhang, Y., Zhao, Q., Xie, Y., Su, K., Yang, J., & Yang, L. (2013). A correlation analysis between the expression of pregnancy-associated plasma protein A in basal decidual cells and recurrent spontaneous abortion. Experimental and Therapeutic Medicine, 6, 485-488. https://doi.org/10.3892/etm.2013.1149
MLA
Zhang, Y., Zhao, Q., Xie, Y., Su, K., Yang, J., Yang, L."A correlation analysis between the expression of pregnancy-associated plasma protein A in basal decidual cells and recurrent spontaneous abortion". Experimental and Therapeutic Medicine 6.2 (2013): 485-488.
Chicago
Zhang, Y., Zhao, Q., Xie, Y., Su, K., Yang, J., Yang, L."A correlation analysis between the expression of pregnancy-associated plasma protein A in basal decidual cells and recurrent spontaneous abortion". Experimental and Therapeutic Medicine 6, no. 2 (2013): 485-488. https://doi.org/10.3892/etm.2013.1149