Hypophosphatemic vitamin D-resistant osteomalacia: A case report
- Authors:
- Min Wang
- Xia Cao
- Bingzhen Cao
View Affiliations
Affiliations: Department of Neurology, Jinan Military General Hospital, Jinan, Shandong 250031, P.R. China
- Published online on: July 8, 2013 https://doi.org/10.3892/etm.2013.1209
-
Pages:
791-795
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Abstract
This study concerns the case of a 59-year-old woman who was admitted to hospital after experiencing systemic bone pain and muscle weakness for more than 2 years. The patient was diagnosed with numerous fractures via bone imaging emission computed tomography (ECT) and hypophosphatemia. Laboratory results showed a high alkaline phosphatase concentration. Thyroid nodules were visible on the thyroid and parathyroid glands during ultrasound examinations. However, no symptomatic or biochemical improvement was observed following a thyroid nodulectomy. The patient was administered large doses of neutral phosphate preparations, vitamin D3 and calcium. A gradual improvement in the condition of the patient was observed. For bone pain associated with multiple fractures in elderly patients, calcium and phosphorus metabolism disorders, and active vitamin D deficiency should be considered and an early diagnosis should be performed.
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View References
|
1
|
Zhang XQ: A case report: mesenchymoma
accompanied by vitamin D-resistant osteomalacia. Chin Med J.
60:150–152. 1980.
|
|
2
|
Zura RD, Minasi JS and Kahler DM:
Tumor-induced osteomalacia and symptomatic looser zones secondary
to mesenchymal chondrosarcoma. J Surg Oncol. 71:58–62. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Murer H, Hernando N, Forster I and Biber
J: Proximal tubular phosphate reabsorption: molecular mechanisms.
Physiol Rev. 80:1373–1409. 2000.PubMed/NCBI
|
|
4
|
Schiavi SC and Kumar R: The phosphatonin
pathway: New insights in phosphate homeostasis. Kidney Int.
65:1–14. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Shimada T, Mizutani S, Muto T, et al:
Cloning and characterization of FGF23 as a causative factor of
tumor-induced osteomalacia. Proc Natl Acad Sci USA. 98:6500–6505.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Müller M, Biedermann M and Strecker W: A
complication during kyphoplasty. Cement penetration through the
azygos vein into the superior vena cava. Orthopade. 35:1183–1186.
2006.(In German).
|
|
7
|
Kobayashi K, Nakao K, Kawai K, et al:
Tumor-induced osteomalacia originating from the temporal bone: a
case report. Head Neck. 33:1072–1075. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Harbeck B, Schöcklmann H, Seekamp A, Czech
N and Mönig H: Tumor-induced osteomalacia: successful treatment by
radio-guided tumor surgery. J Clin Rheumatol. 15:31–34. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Zhang L, Lu CY and Wang T: A case of
hypophosphatemic osteomalacia and literature view. Chin J
Osteoporosis Bone Miner Res. 3:203–206. 2009.
|
