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Article

Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes

  • Authors:
    • Xiangdong Deng
    • Chiyu Jia
    • Fuxing Chen
    • Junquan Liu
    • Zonghai Zhou
  • View Affiliations / Copyright

    Affiliations: The Graduate School, Chinese People's Liberation Army Medical College, Beijing 100039, P.R. China, Plastic Beauty and Burn Repair Center, The 309th Hospital of the Chinese PLA, Beijing 100091, P.R. China, The 97th Hospital of the Chinese PLA, Xuzhou, Jiangsu 221004, P.R. China
  • Pages: 1029-1033
    |
    Published online on: July 23, 2013
       https://doi.org/10.3892/etm.2013.1230
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Abstract

The aim of this study was to investigate the effects of heat stress on the expression of the coxsackievirus and adenovirus receptor (CAR) in mouse skin keratinocytes. Twenty BALB/c mice were randomly divided into two groups: the sham heat (control) and scald groups. Skin specimens were obtained 6 h after the treatments. Changes in the expression of CAR in skin keratinocyte samples were detected by immunohistochemistry, quantitative polymerase chain reaction and western blotting. In an in vitro assay, mouse skin keratinocytes were cultured and randomly divided into two groups: the normal control and heat stress groups. Six hours subsequently, the changes in CAR expression in the two groups were estimated by flow cytometry to determine the differences between the two groups. Heat stress significantly increased the expression of CAR in the mouse skin keratinocytes (P<0.05). The upregulation of CAR in mouse keratinocytes in burn wounds may be beneficial for restoring healing in organisms.
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Copy and paste a formatted citation
Spandidos Publications style
Deng X, Jia C, Chen F, Liu J and Zhou Z: Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes. Exp Ther Med 6: 1029-1033, 2013.
APA
Deng, X., Jia, C., Chen, F., Liu, J., & Zhou, Z. (2013). Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes. Experimental and Therapeutic Medicine, 6, 1029-1033. https://doi.org/10.3892/etm.2013.1230
MLA
Deng, X., Jia, C., Chen, F., Liu, J., Zhou, Z."Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes". Experimental and Therapeutic Medicine 6.4 (2013): 1029-1033.
Chicago
Deng, X., Jia, C., Chen, F., Liu, J., Zhou, Z."Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes". Experimental and Therapeutic Medicine 6, no. 4 (2013): 1029-1033. https://doi.org/10.3892/etm.2013.1230
Copy and paste a formatted citation
x
Spandidos Publications style
Deng X, Jia C, Chen F, Liu J and Zhou Z: Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes. Exp Ther Med 6: 1029-1033, 2013.
APA
Deng, X., Jia, C., Chen, F., Liu, J., & Zhou, Z. (2013). Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes. Experimental and Therapeutic Medicine, 6, 1029-1033. https://doi.org/10.3892/etm.2013.1230
MLA
Deng, X., Jia, C., Chen, F., Liu, J., Zhou, Z."Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes". Experimental and Therapeutic Medicine 6.4 (2013): 1029-1033.
Chicago
Deng, X., Jia, C., Chen, F., Liu, J., Zhou, Z."Effects of heat stress on the expression of the coxsackievirus and adenovirus receptor in mouse skin keratinocytes". Experimental and Therapeutic Medicine 6, no. 4 (2013): 1029-1033. https://doi.org/10.3892/etm.2013.1230
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