Antifatigue effect of Gracilaria eucheumoides in mice

  • Authors:
    • Jin‑Ting Shao
    • Mei‑Yan Wang
    • Lu-Bin Zheng
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  • Published online on: October 15, 2013     https://doi.org/10.3892/etm.2013.1346
  • Pages: 1512-1516
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Abstract

Gracilaria eucheumoides Linn (Gracilariaceae; G. eucheumoides) is abundant in dietary fiber, which aids the clearance of excess cholesterol from the blood and maintains stable blood glucose levels. The aim of the present study was to investigate the antifatigue effect of G. eucheumoides in mice and the physiological and molecular mechanisms underlying this effect. Mice were randomly divided into four groups and three of the groups were administered different doses of G. eucheumoides extract. A loaded swimming test demonstrated that the swimming times of the low‑, medium‑ and high‑dose groups were longer than those of the control group. Examinations revealed that the liver and muscle glycogen, lactate dehydrogenase and blood glucose concentration levels of the treatment groups were higher than those of the control group (P<0.05). However, this was not the case for lactic acid concentration (P>0.05). Quantitative polymerase chain reaction showed that the gene expression levels of glucose transport protein 4 and AMP‑activated protein kinase in the medium‑dose group exhibited the largest increases, compared with the other treatment groups, and were 3.0- and 1.8‑fold higher than those in the control group, respectively. The results of the present study indicated that G. eucheumoides exerts an antifatigue effect on mice.
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December 2013
Volume 6 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shao JT, Wang MY and Zheng L: Antifatigue effect of Gracilaria eucheumoides in mice. Exp Ther Med 6: 1512-1516, 2013.
APA
Shao, J., Wang, M., & Zheng, L. (2013). Antifatigue effect of Gracilaria eucheumoides in mice. Experimental and Therapeutic Medicine, 6, 1512-1516. https://doi.org/10.3892/etm.2013.1346
MLA
Shao, J., Wang, M., Zheng, L."Antifatigue effect of Gracilaria eucheumoides in mice". Experimental and Therapeutic Medicine 6.6 (2013): 1512-1516.
Chicago
Shao, J., Wang, M., Zheng, L."Antifatigue effect of Gracilaria eucheumoides in mice". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1512-1516. https://doi.org/10.3892/etm.2013.1346