Human papillomavirus oncoproteins and apoptosis (Review)

  • Authors:
    • Peiyue Jiang
    • Ying Yue
  • View Affiliations

  • Published online on: October 30, 2013     https://doi.org/10.3892/etm.2013.1374
  • Pages: 3-7
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Abstract

The aim of this study was to review the literature and identify the association between human papillomavirus (HPV) oncoproteins and apoptosis. HPV‑associated apoptosis may be primarily blocked by a number of oncoproteins, including E5, E6 and E7. E5 protein protects cells from tumor necrosis factor‑associated apoptosis; the oncoprotein E6 predominantly inhibits apoptosis through the p53 pathway; and oncoprotein E7 is involved in apoptosis activation and inhibition. In addition, HPV oncoproteins are involved in activating or repressing the transcription of E6/E7. In conclusion, HPV oncoproteins, including E5, E6 and E7 protein, may interfere with apoptosis via certain regulatory principles.
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2014-January
Volume 7 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Jiang P and Jiang P: Human papillomavirus oncoproteins and apoptosis (Review). Exp Ther Med 7: 3-7, 2014
APA
Jiang, P., & Jiang, P. (2014). Human papillomavirus oncoproteins and apoptosis (Review). Experimental and Therapeutic Medicine, 7, 3-7. https://doi.org/10.3892/etm.2013.1374
MLA
Jiang, P., Yue, Y."Human papillomavirus oncoproteins and apoptosis (Review)". Experimental and Therapeutic Medicine 7.1 (2014): 3-7.
Chicago
Jiang, P., Yue, Y."Human papillomavirus oncoproteins and apoptosis (Review)". Experimental and Therapeutic Medicine 7, no. 1 (2014): 3-7. https://doi.org/10.3892/etm.2013.1374