Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
2014-January Volume 7 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-January Volume 7 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Human papillomavirus oncoproteins and apoptosis (Review)

  • Authors:
    • Peiyue Jiang
    • Ying Yue
  • View Affiliations / Copyright

    Affiliations: Department of Gynecological Oncology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 3-7
    |
    Published online on: October 30, 2013
       https://doi.org/10.3892/etm.2013.1374
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this study was to review the literature and identify the association between human papillomavirus (HPV) oncoproteins and apoptosis. HPV‑associated apoptosis may be primarily blocked by a number of oncoproteins, including E5, E6 and E7. E5 protein protects cells from tumor necrosis factor‑associated apoptosis; the oncoprotein E6 predominantly inhibits apoptosis through the p53 pathway; and oncoprotein E7 is involved in apoptosis activation and inhibition. In addition, HPV oncoproteins are involved in activating or repressing the transcription of E6/E7. In conclusion, HPV oncoproteins, including E5, E6 and E7 protein, may interfere with apoptosis via certain regulatory principles.
View Figures

Figure 1

View References

1 

Nichols AC, Palma DA, Chow W, et al: High frequency of activating PIK3CA mutations in human papillomavirus-positive orpharyngeal cancer. JAMA Otolaryngol Head Neck Surg. 139:617–622. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Yuan CH, Filippova M and Duerksen-Hughes P: Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy. Viruses. 4:3831–3850. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Kaspersen MD, Larsen PB, Ingerslev HJ, et al: Identification of multiple HPV types on spermatozoa from human sperm donors. PLoS One. 6:e180952011. View Article : Google Scholar : PubMed/NCBI

4 

Schlecht NF, Kulaga S, Robitaille J, et al: Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. JAMA. 286:3106–3114. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Alam MS, Ali A, Mehdi SJ, et al: HPV typing and its relation with apoptosis in cervical carcinoma from Indian population. Tumor Biol. 33:17–22. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Pisani P, Bray F and Parkin DM: Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer. 97:72–81. 2002. View Article : Google Scholar : PubMed/NCBI

7 

zur Hausen H: Papillomaviruses in the causation of human cancers - a brief historical account. Virology. 384:260–265. 2009.PubMed/NCBI

8 

Garnett TO and Duerksen-Hughes PJ: Modulation of apoptosis by human papillomavirus (HPV) oncoproteins. Arch Virol. 151:2321–2335. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Mischo A, Ohlenschläger O, Hortschansky P, Ramachandran R and Görlach M: Structural insights into a wildtype domain of the oncoprotein E6 and its interaction with a PDZ domain. PLoS One. 8:e625842013. View Article : Google Scholar : PubMed/NCBI

10 

Cai Q, Lv L, Shao Q, Li X and Dian A: Human papillomavirus early proteins and apoptosis. Arch Gynecol Obstet. 287:541–548. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Mantovani F and Banks L: The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene. 20:7874–7887. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Nominé Y, Masson M, Charbonnier S, et al: Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis. Mol Cell. 21:665–678. 2006.PubMed/NCBI

13 

Ristriani T, Nominé Y, Masson M, Weiss E and Travé G: Specific recognition of four-way DNA junctions by the C-terminal zinc-binding domain of HPV oncoprotein E6. J Mol Biol. 305:729–739. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Huibregtse JM, Scheffner M and Howley PM: A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus type 16 or 18. EMBO J. 10:4129–4135. 1991.PubMed/NCBI

15 

Scheffner M, Huibregtse JM, Vierstra RD and Howley PM: The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell. 75:495–505. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Murray-Zmijewski F, Slee EA and Lu X: A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol. 9:702–712. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Howie HL, Katzenellenbogen RA and Galloway DA: Papillomavirus E6 proteins. Virology. 384:324–334. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Blanchette P and Branton PE: Manipulation of the ubiquitin-proteasome pathway by small DNA tumor virus. Virology. 384:317–323. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Khoronenkova SV and Dianov GL: The emerging role of Mule and ARF in the regulation of base exicision repair. FEBS Lett. 585:2831–2835. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Kumar A, Zhao Y, Meng G, et al: Human papillomovirus oncoperotein E6 inactivates the transcriptional coactivator human ADA3. Mol Cell Biol. 22:5801–5812. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Aylon Y and Oren M: p53: guardian of ploidy. Mol Oncol. 5:315–323. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Contreras-Paredes A, De la Cruz-Hernández E, Martínez-Ramírez I, Dueñas-González A and Lizano M: E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway. Virology. 383:78–85. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Underbrink MP, Howie HL, Bedard KM, Koop JI and Galloway DA: The E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. J Virol. 82:10408–10417. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Gewies A: Introduction to apoptosis. ApoReview. 1–26. 2003.

25 

Gewin L and Galloway DA: E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-Myc. J Virol. 75:7198–7201. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Venuti A, Paolini F, Nasir L, et al: Papillomavirus E5: the smallest oncoprotein with many functions. Mol Cancer. 10:1402011. View Article : Google Scholar

27 

Chang JL, Tsao YP, Liu DW, Huang SJ, Lee WH and Chen SL: The expression of HPV-16 E5 protein in squamous neoplastic changes in the uterine cervix. J Biomed Sci. 8:206–213. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Conrad M, Bubb VJ and Schlegel R: The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associated with the 16-kilodalton pore-forming protein. J Virol. 67:6170–6178. 1993.PubMed/NCBI

29 

Borzacchiello G, Roperto F, Campo MS and Venuti A: 1st international workshop on papillomavirus E5 oncogene - a report. Virology. 408:135–137. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Chen SL and Mounts P: Transforming activity of E5a protein of human papillomavirus type 6 in NIH 3T3 and C127 cells. J Virol. 64:3226–3233. 1990.PubMed/NCBI

31 

Hu L, Potapova TA, Li S, et al: Expression of HPV16 E5 produces enlarged nuclei and polyploidy through endoreplication. Virology. 405:342–351. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Kabsch K and Alonso A: The human papillomavirus type 16 E5 protein impairs TRAIL- and FasL-mediated apoptosis in HaCaT cells by different mechanisms. J Virol. 76:12162–12172. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Wang X, Shi Q, Xu K, et al: Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells. PLoS One. 6:e146022011. View Article : Google Scholar

34 

Xu K, Wang X, Shi Q, et al: Human prion protein mutants with deleted and inserted octarepeats undergo different pathways to trigger cell apoptosis. J Mol Neurosci. 43:225–234. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Sudarshan SR, Schlegel R and Liu XF: The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes. Biochem Biophys Res Commun. 399:617–622. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Condjella R, Liu X, Suprynowicz F, et al: The canine papillomavirus E5 protein signals from the endoplasmic reticulum. J Virol. 83:12833–12841. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Oh JM, Kim SH, Lee YI, et al: Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells. Carcinogenesis. 30:141–149. 2009.

38 

McLaughlin-Drubin ME and Münger K: The human papillomavirus E7 oncoprotein. Virology. 384:335–344. 2009. View Article : Google Scholar

39 

Toscano-Garibay JD, Benitez-Hess ML and Alvarez-Salas LM: Isolation and characterization of an RNA aptamer of the HPV-16 E7 oncoprotein. Arch Med Res. 42:88–96. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Ohlenschläger O, Seiboth T, Zengerling H, et al: Solution structure of the partially folded high-risk human papillomavirus 45 oncoprotein E7. Oncogene. 25:5953–5959. 2006.PubMed/NCBI

41 

Liu X, Clements A, Zhao K and Marmorstein R: Structure of human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor. J Biol Chem. 281:578–586. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Ghim S, Jenson AB, Bubier JA, Silva KA, Smith RS and Sundberg JP: Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1–14. Exp Mol Pathol. 85:77–82. 2008.PubMed/NCBI

43 

Zimmermann M, Koreck A, Meyer N, et al: TNF-like weak inducer of apoptosis (TWEAK) and TNF-alpha cooperate in the induction of keratinocyte apoptosis. J Allergy Clin Immunol. 127:200–207. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Pardali K and Moustakas A: Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta. 1775:21–62. 2007.

45 

DeMasi J, Huh KW, Nakatani Y, Münger K and Howley PM: Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding. Proc Natl Acad Sci USA. 102:11486–11491. 2005. View Article : Google Scholar : PubMed/NCBI

46 

DeMasi J, Chao MC, Kumar AS and Howley PM: Bovine papillomavirus E7 oncoprotein inhibits anoikis. J Virol. 81:9419–9425. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Severino A, Abbruzzese C, Manente L, et al: Human papillomavirus-16 E7 interacts with Siva-1 and modulates apoptosis in HaCaT human immortalized keratinocytes. J Cell Physiol. 212:118–125. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Wells SI, Francis DA, Karpova AY, Dowhanick JJ, Benson JD and Howley PM: Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathway. EMBO J. 19:5762–5771. 2000. View Article : Google Scholar

49 

Mazumder Indra D, Singh RK, Mitra S, Dutta S, et al: Genetic and epigenetic changes of HPV16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression. Gynecol Oncol. 123:597–604. 2011.PubMed/NCBI

50 

Tang S, Tao M, McCoy JP Jr and Zheng ZM: The E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16-or type 18-positive cervical cancer cell lines via translation reinitiation. J Virol. 80:4249–4263. 2006.

51 

Dell G and Gaston K: Human papillomavirus and their role in cervical. Cell Mol Life Sci. 58:1923–1942. 2001. View Article : Google Scholar

52 

Webster K, Parish J, Pandya M, Stern PL, Clarke AR and Gaston K: The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. J Biol Chem. 275:87–94. 2000. View Article : Google Scholar : PubMed/NCBI

53 

Wu X and Levine AJ: p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA. 91:3602–3606. 1994. View Article : Google Scholar : PubMed/NCBI

54 

Frattini MG, Hurst SD, Lim HB, Swaminathan S and Laimins LA: Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein. EMBO J. 16:318–331. 1997. View Article : Google Scholar

55 

Bouvard V, Storey A, Pim D and Banks L: Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes. EMBO J. 13:5451–5459. 1994.PubMed/NCBI

56 

Kim K, Gamer-Hamrick PA, Fisher C, Lee D and Lambert PF: Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection. J Virol. 77:12450–12459. 2003. View Article : Google Scholar : PubMed/NCBI

57 

Dong XP, Stubenrauch F, Beyer-Finkler E and Pfister H: Prevalence of deletions of YY1-binding sites in episomal HPV 16 DNA from cervical cancers. Int J Cancer. 58:803–808. 1994. View Article : Google Scholar : PubMed/NCBI

58 

Pett M and Coleman N: Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis? J Pathol. 212:356–367. 2007. View Article : Google Scholar : PubMed/NCBI

59 

Arisa-Pulido H, Peyton CL, Joste NE, Vargas H and Wheeler CM: Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer. J Clin Microbiol. 44:1755–1762. 2006. View Article : Google Scholar

60 

Bhattacharjee B and Sengupta S: CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology. 354:280–285. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jiang P and Yue Y: Human papillomavirus oncoproteins and apoptosis (Review). Exp Ther Med 7: 3-7, 2014.
APA
Jiang, P., & Yue, Y. (2014). Human papillomavirus oncoproteins and apoptosis (Review). Experimental and Therapeutic Medicine, 7, 3-7. https://doi.org/10.3892/etm.2013.1374
MLA
Jiang, P., Yue, Y."Human papillomavirus oncoproteins and apoptosis (Review)". Experimental and Therapeutic Medicine 7.1 (2014): 3-7.
Chicago
Jiang, P., Yue, Y."Human papillomavirus oncoproteins and apoptosis (Review)". Experimental and Therapeutic Medicine 7, no. 1 (2014): 3-7. https://doi.org/10.3892/etm.2013.1374
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang P and Yue Y: Human papillomavirus oncoproteins and apoptosis (Review). Exp Ther Med 7: 3-7, 2014.
APA
Jiang, P., & Yue, Y. (2014). Human papillomavirus oncoproteins and apoptosis (Review). Experimental and Therapeutic Medicine, 7, 3-7. https://doi.org/10.3892/etm.2013.1374
MLA
Jiang, P., Yue, Y."Human papillomavirus oncoproteins and apoptosis (Review)". Experimental and Therapeutic Medicine 7.1 (2014): 3-7.
Chicago
Jiang, P., Yue, Y."Human papillomavirus oncoproteins and apoptosis (Review)". Experimental and Therapeutic Medicine 7, no. 1 (2014): 3-7. https://doi.org/10.3892/etm.2013.1374
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team