Solitary schwannoma of the sural nerve: An unusual clinical presentation

Yamamoto,Kosuke; Nishio,Jun; Yano,Shintaro; Naito,Masatoshi

doi:10.3892/etm.2013.1395

2014-January Volume 7 Issue 1

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

2014-January Volume 7 Issue 1

Full Size Image

Article

Solitary schwannoma of the sural nerve: An unusual clinical presentation

Authors:
- Kosuke Yamamoto
- Jun Nishio
- Shintaro Yano
- Masatoshi Naito
View Affiliations / Copyright

Affiliations: Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka 814‑0180, Japan
Pages: 90-92
|
Published online on: November 8, 2013

https://doi.org/10.3892/etm.2013.1395
Expand metrics +

Abstract

Schwannomas may arise from any peripheral nerve containing Schwann cells. However, sural nerve schwannoma is extremely rare. In this study, a case of solitary schwannoma originating from the sural nerve in a 42‑year‑old male is presented. Physical examination revealed a 3‑cm, elastic‑hard, mobile, non‑tender mass, while neurovascular examinations, including Tinel's sign, were normal. Magnetic resonance imaging revealed an oval‑shaped subcutaneous mass with iso‑signal intensity relative to skeletal muscle on T1‑weighted sequences. T2‑weighted spectral presaturation with inversion recovery sequences showed higher signal intensity peripherally and lower signal intensity centrally, representing a target sign. Contrast‑enhanced T1‑weighted sequences demonstrated a marked central enhancement of the mass. The tumor was completely enucleated using an intracapsular technique. Histological examination confirmed the diagnosis of a schwannoma, consisting mainly of Antoni A tissue. The patient had no evidence of local recurrence and no neurological deficit at the final follow‑up. Although rare, schwannoma should be considered in the differential diagnosis of a well‑defined, oval, subcutaneous mass in the posterior aspect of the lower leg.

View Figures

View References

1	Antonescu CR, Perry A and Woodruff JM: Schwannoma (including variants). World Health Organization Classification of Tumours of Soft Tissue and Bone. Fletcher CDM, Bridge JA, Hogendoorn PCW and Mertens F: 4th edition. IARC Press; Lyon: pp. 170–172. 2013
2	Riedl O and Frey M: Anatomy of the sural nerve: cadaver study and literature review. Plast Reconstr Surg. 131:802–810. 2013. View Article : Google Scholar : PubMed/NCBI
3	Isobe K, Shimizu T, Akahane T and Kato H: Imaging of ancient schwannoma. AJR Am J Roentgenol. 183:331–336. 2004. View Article : Google Scholar : PubMed/NCBI
4	Kim DH, Murovic JA, Tiel RL, Moes G and Kline DG: A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg. 102:246–255. 2005.
5	Fellegara G and Bisceglia M: Intraneural schwannoma. Int J Surg Pathol. 16:57–58. 2008. View Article : Google Scholar : PubMed/NCBI
6	Ogose A, Hotta T, Morita T, Otsuka H and Hirata Y: Multiple schwannomas in the peripheral nerves. J Bone Joint Surg Br. 80:657–661. 1998. View Article : Google Scholar
7	Jee WH, Oh SN, McCauley T, Ryu KN, Suh JS, Lee JH, Park JM, Chun KA, Sung MS, Kim K, Lee YS, Kang YK, Ok IY and Kim JM: Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol. 183:629–633. 2004. View Article : Google Scholar : PubMed/NCBI
8	Koga H, Matsumoto S, Manabe J, Tanizawa T and Kawaguchi N: Definition of the target sign and its use for the diagnosis of schwannomas. Clin Orthop Relat Res. 464:224–229. 2007.PubMed/NCBI
9	Ahmed AR, Watanabe H, Aoki J, Shinozaki T and Takagishi K: Schwannoma of the extremities: the role of PET in preoperative planning. Eur J Nucl Med. 28:1541–1551. 2001. View Article : Google Scholar : PubMed/NCBI
10	Beaulieu S, Rubin B, Djang D, Conrad E, Turcotte E and Eary JF: Positron emission tomography of schwannomas: emphasizing its potential in preoperative planning. AJR Am J Roentgenol. 182:971–974. 2004. View Article : Google Scholar : PubMed/NCBI
11	Benz MR, Czernin J, Dry SM, Tap WD, Allen-Auerbach MS, Elashoff D, Phelps ME, Weber WA and Eilber FC: Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer. 116:451–458. 2010. View Article : Google Scholar
12	Antonescu CR, Brems H, Legius E and Woodruff JM: Neurofibroma (including variants). World Health Organization Classification of Tumours of Soft Tissue and Bone. Fletcher CDM, Bridge JA, Hogendoorn PCW and Mertens F: 4th edition. IARC Press; Lyon: pp. 174–176. 2013
13	Murphey MD, Smith WS, Smith SE, Kransdorf MJ and Temple HT: From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics. 19:1253–1280. 1999. View Article : Google Scholar : PubMed/NCBI
14	Hachisuga T, Hashimoto H and Enjoji M: Angioleiomyoma: a clinicopathologic reappraisal of 562 cases. Cancer. 54:126–130. 1984. View Article : Google Scholar : PubMed/NCBI
15	Gupte C, Butt SH, Tirabosco R and Saifuddin A: Angioleiomyoma: magnetic resonance imaging features in ten cases. Skeletal Radiol. 37:1003–1009. 2008. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Solitary schwannoma of the sural nerve: An unusual clinical presentation

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles